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About Sickkids
About SickKids

Joe T.R. Clarke, BSc, MD, MSc, PhD, MSc, FRCPC, FCCMG

The Hospital for Sick Children
Physician
Clinical and Metabolic Genetics

University of Toronto
Professor, Clinician-Teacher
Department of Paediatrics

Chair Positions

Chair, Ontario Advisory Committee on Newborn & Childhood Screening

Other Positions

Professeur d’Enseignement Clinique
Centre Hospitalier Universitaire de Sherbrooke (CHUS)
Université de Sherbrooke, Québec

University Health Network
Metabolic Geneticist
Division of Neurology, Adult Genetic Services


Phone: 416-813-5335
Fax: 416-813-5345
Email: jtrc@sickkids.ca

Brief Biography

Dr. Clarke is a Professor of Pediatrics at the University of Toronto. He graduated in Medicine from the University of Alberta in 1965. He was a Paediatrics Resident at The Hospital for Sick Children (SickKids) in Toronto from 1966-68, then a Research Fellow in the Department of Experimental Neurochemistry at the Montreal Neurological Institute where he pursued graduate studies in Biochemistry at McGill University. He is a Paediatrics Fellow of the Royal College of Physicians of Canada, and a Fellow of the Canadian College of Medical Geneticists with specialty in the management of inherited metabolic diseases.

Dr. Clarke was on faculty in the Division of Pediatrics at the University of Calgary from 1972-74. From 1974-83, he was on the faculty of the Department of Pediatrics of Dalhousie University in Halifax, Nova Scotia. He was, in 1976, a founding member of the executive of the Garrod Association, a national association of specialists and scientists committed to the improvement of the diagnosis and treatment of inherited metabolic diseases in Canada.

In 1983, he joined SickKids as an Associate Professor in paediatrics at the University of Toronto. He was, for 11 years, Head of the Division of Clinical Genetics of SickKids. When the Genetic Metabolic Diseases Program was established, he become the Director of the department, a position which he held until 2006. He is currently a Senior Associate Scientist in the Research Institute at SickKids. He is also Director of Postgraduate Education in Medical Genetics at the University of Toronto. He chairs the Ontario Advisory Committee on Newborn and Childhood Screening and is a member of the Ontario Advisory Committee on Genetics.

For several years, he has served as an Advisor to the Government of Canada and various provincial governments on matters relating to newborn screening and to the regulation and reimbursement for the treatment of inherited metabolic diseases. He obtained his MSc in health policy at the University of Toronto in 2001.

Dr. Clarke has authored or co-authored over 200 peer-reviewed original articles in medical scientific journals, in addition to many book chapters. He is sole author of A Clinical Guide to Inherited Metabolic Diseases, originally published by Cambridge University Press in 1996, an internationally acclaimed book, now in its 3rd edition, written primarily for advanced postgraduate medical trainees and general physicians. He has given over 100 invited lectures on various aspects of the management of inherited metabolic diseases in centres around the world, including Australia, Brazil, Argentina, India, and China, as well as the United States and Canada.

Dr. Clarke's research interests include studies on lysosomal storage diseases, especially relating to treatment. He has been principal investigator on a number of clinical trials exploring innovative approaches to the treatment of lysosomal storage diseases, such as Fabry disease and GM2 gangliosidosis. For over 35 years, he has pursued clinical research on the impact of treatment on children with PKU. He holds or has held research grants from the Medical Research Council of Canada, as well as many philanthropic organizations and industry.

Publications

Dr. Clarke is author of over 200 peer-reviewed articles in scientific journals and the author and co-author of various medical speciality books:

Pubmed

Books