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About Sickkids
About SickKids

Ernest Cutz, MD, FRCPC

The Hospital for Sick Children
Senior Staff Pathologist
Paediatric Laboratory Medicine

Research Institute
Senior Scientist Emeritus
Translational Medicine

University of Toronto
Professor
Department of Laboratory Medicine & Pathobiology


Phone: 416-813-6517
Fax: 416-813-5974
Email: ernest.cutz@sickkids.ca

Brief Biography

Dr. Cutz received his MD from Charles University Medical School, Prague, Czechoslovakia. He contined his post-graduate studies in the Department of Histology& Embryology at Charles University in Prague and at the Centre Anticancereux in Toulouse, France. He later moved to Toronto and joined the Department of Pathology at The Hospital for Sick Children, with
work at the Toronto General Hospital, Princess Margaret and Wellesley Hospital. Cutz has an FRCP(C) Speciality cerification in Anatomical Pathology from Royal College of Physicians and Surgeons of Canada.

Clinical Activities

In clinically-related research we continue in our studies of congenital enteropathies (ie.Micovillous Inclusion Disease[4])
as well as novel forms of paediatric interstitial lung disease (ie.Pulmonary Interstitial Glycogenosis[5]).

Research Interests

Current areas of research: In the area of basic research we investigate the role and function of amine and peptide producing Pulmonary Neuroendocrine Cells (PNEC) in developing lungs, during neonatal adaptation and in a variety of paediatric lung diseases. PNEC are widely distributed within the airway mucosa as solitary cells and as innervated cell clusters, called
Neuroepithelial bodies(NEB). PNEC are the first cell type to differentiate in fetal lung and are numerous in the fetal/neonatal lung suggesting that they have a significant role during lung development. We have found that NEB cells express an O2 sensing molecular complex (O2 sensing protein-NADPH oxidase coupled to an O2 sensitive K+ channel) that modulate amine /peptide secretion, affecting lung homeostasis(1,2) .

Objectives of our studies on airway O2 sensor in NEB cells are:

a) molecular and functional characterization of O2/CO2 and pH sensing mechanism;
b) the mechanisms and transmission of chemosensory stimuli to define physiologic function.

Studies on PNEC in developing lung include the interaction of hypoxia/ HIF’s, neurogenic gene expression (ie .Mash1), PNEC differentiation and their potential role as lung stem cell niche(3).

Achievements

Youngson C, Nurse C, Yeger H, Cutz E: Oxygen sensing in airway chemoreceptors. Nature 365:153-155, 1993 .

Fu XW, Wang D, Nurse CA, Dinauer MC, Cutz E: NADPH oxidase in an O2 sensor in airway chemoreceptors: evidence from K+ current modulation in wild-type and oxidase-deficient mice. Proc Natl Acad Sci (USA) 97:4374-4379, 2000.

Cutz E,Yeger H,Pan J.Pulmonary neuroendocrine cell system-recent advances .(Invited review)Pediatr Dev Pathol 10:419-435,2007

Cutz E, Rhoads JM, Drumm B, Sherman P, Drurie PR, Forstner GG: Microvillus inclusion disease: an inherited defect of brush-border assembly and differentiation. New Eng J Med 320:646-651, 1989.

Canakis AM, Cutz E, Manson D, O’Brodovich H: Pulmonary interstitial glycogenosis: a new variant of neonatal interstitial lung disease. Am J Respir Crit Care Med 165:1557-1565, 2002 .