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About Sickkids
About SickKids

Peter Kannu, MB ChB (Otago), PhD, DCH, FRACP

The Hospital for Sick Children
Staff Physician
Clinical and Metabolic Genetics

Research Institute
Associate Scientist
Developmental & Stem Cell Biology

University of Toronto
Associate Professor
Pediatrics


Phone: (416) 813-7654 Ext. 301480
Fax: (416) 813-5345
Email: peter.kannu@sickkids.ca

Brief Biography

Peter Kannu is a Clinical Geneticist at The Hospital for Sick Children and an investigator at the SickKids Research Institute. His special area of expertise is in the inherited disorders of the skeleton that cause short stature, arthritis and osteoporosis. He also provides genetic counseling for children affected by inherited skin disorders and Neurofibromatosis type 1.

Kannu graduated from The University of Otago in 1994, and went on to complete his specialty training in paediatrics, and then in clinical genetics. His post-graduate qualifications include: Fellowship of the Royal Australasian College of Physicians, Clinical Geneticist of the Human Genetics Society of Australasia (HGSA), Postgraduate Diploma in Child Health and a PhD from the University of Melbourne. At the SickKids Research Institute, Kannu continues his research into rare human conditions causing disorders of the skeleton. He is currently working on identifying causes of cartilage cell damage which lead to osteoarthritis.

Clinical Care Activities

Kannu's clinical care activities include the genetic assessment of short stature, childhood osteoarthritis and osteoporosis, Neurofibromatosis and inherited skin disorders.

Research Activities

  •  Neurofibromatosis type 1
  • Juvenile idiopathic osteoporosis
  • Skeletal dysplasias
  • Osteoarthritis
  • Cartilage injury

Selected Publications

Braun DA, Rao J, Mollet G, Schapiro D, Daugeron MC, Tan W, Gribouval O, Boyer O, Revy P, Jobst-Schwan T, Schmidt JM, Lawson JA, Schanze D, Ashraf S, Ullmann JFP, Hoogstraten CA, Boddaert N, Collinet B, Martin G, Liger D, Lovric S, Furlano M, Guerrera IC, Sanchez-Ferras O, Hu JF, Boschat AC, Sanquer S, Menten B, Vergult S, De Rocker N, Airik M, Hermle T, Shril S, Widmeier E, Gee HY, Choi WI, Sadowski CE, Pabst WL, Warejko JK, Daga A, Basta T, Matejas V, Scharmann K, Kienast SD, Behnam B, Beeson B, Begtrup A, Bruce M, Ch'ng GS, Lin SP, Chang JH, Chen CH, Cho MT, Gaffney PM, Gipson PE, Hsu CH, Kari JA, Ke YY, Kiraly-Borri C, Lai WM, Lemyre E, Littlejohn RO, Masri A, Moghtaderi M, Nakamura K, Ozaltin F, Praet M, Prasad C, Prytula A, Roeder ER, Rump P, Schnur RE, Shiihara T, Sinha MD, Soliman NA, Soulami K, Sweetser DA, Tsai WH, Tsai JD, Topaloglu R, Vester U, Viskochil DH, Vatanavicharn N, Waxler JL, Wierenga KJ, Wolf MTF, Wong SN, Leidel SA, Truglio G, Dedon PC, Poduri A, Mane S, Lifton RP, Bouchard M, Kannu P, Chitayat D, Magen D, Callewaert B, van Tilbeurgh H, Zenker M, Antignac C, Hildebrandt F. Mutations in KEOPS-complex genes cause nephrotic syndrome with primary microcephaly. Nat Genet. 2017 Oct;49(10):1529-1538.

Jobling RK, Lara-Corrales I, Hsiao MC, Shugar A, Hedges S, Messiaen L, Kannu  P. Mosaicism for a SPRED1 deletion revealed in a patient with clinically suspected mosaic neurofibromatosis. Br J Dermatol. 2017 Apr;176(4):1077-1078.

Lara-Corrales I, Moazzami M, García-Romero MT, Pope E, Parkin P, Shugar A, Kannu P. Mosaic Neurofibromatosis Type 1 in Children: A Single-Institution Experience. J Cutan Med Surg. 2017 Sep/Oct;21(5):379-382.

Ghadakzadeh S, Kannu P, Whetstone H, Howard A, Alman BA .β-Catenin modulation in neurofibromatosis type 1 bone repair: therapeutic implications.FASEB J. 2016 Sep;30(9):3227-37.

Gray MJ, Kannu P, Sharma S, Neyt C, Zhang D, Paria N, Daniel PB, Whetstone H, Sprenger HG, Hammerschmidt P, Weng A, Dupuis L, Jobling R, Mendoza-Londono R, Dray M, Su P, Wilson MJ, Kapur RP, McCarthy EF, Alman BA, Howard A, Somers GR, Marshall CR, Manners S, Flanagan AM, Rathjen KE, Karol LA, Crawford H, Markie DM, Rios JJ, Wise CA, Robertson SP. Mutations Preventing Regulated Exon Skipping in MET Cause Osteofibrous Dysplasia. Am J Hum Genet. 2015 Dec 3;97(6):837-47.

Kannu P, Howard A. Perthes' disease. BMJ. 2014 Sep 23;349:g5584.

Kannu P, Bateman JF, Randle S, Cowie S, du Sart D, McGrath S, Edwards M, Savarirayan R. Premature arthritis is a distinct type II collagen phenotype. Arthritis Rheum. 2010 May;62(5):1421-30

Kannu P, Bateman JF, Belluoccio D, Fosang AJ, Savarirayan R. Employing molecular genetics of chondrodysplasias to inform the study of osteoarthritis. Arthritis Rheum. 2009 Feb;60(2):325-34.