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About Sickkids
About SickKids

Irena Nulman, MD, FRCPC Neurology, PhD (C)

The Hospital for Sick Children
Staff
Clinical Pharmacology and Toxicology

Associate Director
MotherRisk

Research Institute
Associate Scientist
Child Health Evaluative Sciences

University of Toronto
Professor
Paediatrics

Fellowship Program Director
Clinical Pharmacology

Other Positions
Fetal Alcohol Syndrome Clinic
Director


Phone: 416-813-7887
Email: irena.nulman@sickkids.ca

Brief Biography

Associate Director of the Motherisk Program, Director of Fetal Alcohol Syndrome Clinic, Staff Pharmacologist, Program Director of Fellowship Training in Clinical Pharmacology and Professor of Pediatrics, University of Toronto, Associate Scientist, Research Institute, The Hospital for Sick Children, University of Toronto .
Research
Dr. Nulman’s clinical research is in the area of Behavioural Teratology with a focus on the effects of maternal psychotropic medications (anticonvulsants, antidepressants, antipsychotics antiemetics, antineoplastic) and drugs of abuse, on fetal/child central nervous system development. Behavioural Teratology, an un-separable part of reproductive toxicology, is a novel field. In collaboration with the psychology division, Dr. Nulman established a) the first National Behavioral Teratology Research Program. She has the largest number of publications on this topic worldwide, published in leading medical journals influencing clinical decision making based on these evidence-based information, preventing children’s cognitive and mental health. Dr. Nulman is leading the b) first National Survey of Cancer in Pregnancy at SickKids.  In collaboration with European colleagues, she investigates the long-term effects of maternal perinatal cancer and its treatment on developing fetuses and future pediatric health. This area is severely understudied. Evidence–based information on cancer in pregnancy results in many saved lives.
She established herself as an c) expert on reproductive alcohol toxicity, Fetal Alcohol Spectrum Disorder, which leads to child mental retardation and impaired behaviour. Dr. Nulman was actively involved in the developing Canadian National Guidelines with the objective of establishing national standards of care, screening, recording, counseling, and research on alcohol-use in women of child-bearing age.  Practice Guidelines have been reviewed and approved by the Executive and Council of the Society of Obstetrics and Gynecology of Canada.

Her reproductive toxicology research was awarded with the CIHR grants and CMAJ Top-Achievement Award in Heath Research.

Publications

Choi JS, Koren G, Nulman I. Pregnancy and isotretinoin therapy. Canadian Medical Association Journal 2013: Jan 7. [Epub ahead of print])

Choi JS, Koren G, Nulman I. Re: Letter to the Editor: Pregnancy and isotretinoin therapy. Canadian Medical Association Journal 2013: 185: pp 508.Koren G, Nulman I, Aleksa K, Gareri J, Einarson A, Ito S. Essay for the 2011 CIHR/CMAJ award: Motherisk-caring for mothers, protecting the unborn. Canadian Medical Association Journal 2012: 184: pp E155-7.Nash K, 

Stevens S, Rovet J, Fantus E, Nulman I, Sorbara D, Koren G. Towards identifying a characteristic neuropsychological profile for fetal alcohol spectrum disorders. 1. Analysis of the Motherisk FASD clinic. Journal of Population Therapeutics and Clinical Pharmacology 2013: 20: pp e44-52.

Nulman I, Koren G, Rovet J, Barrera M, Pulver A, Streiner D, Feldman B. Neurodevelopment of children following prenatal exposure to venlafaxine, selective serotonin reuptake inhibitors, or untreated maternal depression.  American Journal of Psychiatry 2012: 169: pp 1165-74.

Sadowski A, Todorow M, Yazdani Brojeni P, Koren G, Nulman I. Pregnancy outcomes following maternal exposure to second-generation antipsychotics given with other psychotropic drugs: a cohort study. British Medical Journal 2013: 3: e003062.

Stevens S, Major D, Rovet J, Koren G, Fantus E, Nulman I, Desrocher M. Social problem solving in children with fetal alcohol spectrum disorders. Journal of Population Therapeutics and Clinical Pharmacology 2012: 19: pp e99-110.

Stevens SA, Nash K, Fantus E, Nulman I, Rovet J, Koren G. Towards identifying a characteristic neuropsychological profile for fetal alcohol spectrum disorders. 2. Specific caregiver-and teacher-rating. Journal of Population Therapeutics and Clinical Pharmacology 2013: 20: pp e44-52.