Biostatistics Methodology Unit
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Publications

Selected Recent Publications 2008

Manor-Shulman O, Beyene J, Frndova H, Parshuram CS. Quantifying the volume of documented clinical information in critical illness. J Crit Care. 2008 Jun;23(2):245-250.

Friedrich JO, Adhikari NK, Beyene J. The ratio of means method as an alternative to mean differences for analyzing continuous outcome variables in meta-analysis: a simulation study. BMC Med Res Methodol. 2008 May 21;8(1):32. [Epub ahead of print]

Kavanagh T, Hamm LF, Beyene J, Mertens DJ, Kennedy J, Campbell R, Fallah S, Shephard RJ. Usefulness of improvement in walking distance versus peak oxygen uptake in predicting prognosis after myocardial infarction and/or coronary artery bypass grafting in men. Am J Cardiol. 2008 May 15;101(10):1423-7.

Eckermann S, Willan AR. The option value of delay in health technology assessment. Medical Decision Making, published online: May 13, 2008 as DOI:10.1177/0272989X07312477.

Eckermann S, Willan AR. Globally optimal trial design for local decision making. Health Economics, published online: Apr 24 2008. DOI: 10.1002/hec.1353.

Eckermann S, Briggs A, Willan AR. Health technology assessment in the cost-disutility plane. Medical Decision Making 2008; 28:172-181.

Ray JG, Moineddin R, Bell CM, Thiruchelvam D, Creatore MI, Gozdyra P, Cusimano M, Redelmeier DA. Alcohol sales and risk of serious assault. PLoS Med. 2008; 5(5):e104.

Butt DA, Lock M, Lewis JE, Ross S, Moineddin R. Gabapentin for the treatment of menopausal hot flashes: a randomized controlled trial. Menopause. 2008;15(2):310-8.

Matheson FI, Moineddin R, Glazier RH. The weight of place: a multilevel analysis of gender, neighborhood material deprivation, and body mass index among Canadian adults. Soc Sci Med. 2008 Feb; 66(3):675-90.

Rujkijyanont P, Watanabe KI, Ambekar C, Wang H, Schimmer A, Beyene J, Dror Y. SBDS-deficient cells undergo accelerated apoptosis through the Fas-pathway. Haematologica. 2008 Mar; 93(3):363-71. Epub 2008 Feb 11.

Abrahamyan L, Johnson SR, Beyene J, Shah PS, Feldman BM. Quality of randomized clinical trials in juvenile idiopathic arthritis. Rheumatology. 2008 May; 47(5):640-5.

Jenkins DJ, Josse AR, Beyene J, Dorian P, Burr ML, LaBelle R, Kendall CW, Cunnane SC. Fish-oil supplementation in patients with implantable cardioverter defibrillators: a meta-analysis. CMAJ 2008 Jan 15; 178(2):157-64.

Pole JD, Mustard CA, To T, Beyene J, Allen AC. Antenatal steroid therapy and childhood asthma: Is there a possible link? Med Hypotheses. 2008; 70(5):981-9.

Eckermann S, Willan AR. Time and EVSI wait for no patient. Value in Health 2008; 11: 522-526.

2007

Willan AR, Kowgier ME. Cost-effectiveness analysis of a multinational RCT with a binary measure of effectiveness and an interacting covariate . Health Economics, published online: Sep 3 2007 DOI: 10.1002/hec.1289.

Hossain A, Willan AR. Approximate MLEs of the parameters of location-scale models under type II censoring. Statistics 2007; 41(5): 385-394.

Willan AR. Clinical decision making and the expected value of information. Clinical Trials 2007; 4:279-285.

Pullenayegum EM, Willan AR. Semi-parametric regression models for cost-effectiveness analysis: improving the efficiency of estimation from censored data. Statistics in Medicine 2007; 26:3274-3299.

Eckermann S, Willan AR. Expected value of information and decision making in HTA. Health Economics 2007; 16:195-209.

McIsaac WJ, Moineddin R, Ross S. Validation of a decision aid to assist physicians in reducing unnecessary antibiotic drug use for acute cystitis. Arch Intern Med. 2007;167(20):2201-6.

Hossain A. and Willan A.R. Approximate MLEs for the parameters of location-scale models under type II censoring. Statistics 2007; 41(5): 385-394.

Urquia ML, Frank JW, Glazier RH, Moineddin R. Birth outcomes by neighborhood income and recent immigration in Toronto. Health Rep. 2007;18(4):21-30.

Moineddin R, Matheson FI, Glazier RH. A simulation study of sample size for multilevel logistic regression models. BMC Med Res Methodol. 2007 Jul 16; 7:34.

Rangrej J, Beyene J, Hu P, Paterson AD. Sex, age and generation effects on genome-wide linkage analysis of gene expression in transformed lymphoblasts. BMC Proc. 2007;1 Suppl 1:S92. Epub 2007 Dec 18.

Hu P, Lan H, Xu W, Beyene J, Greenwood CM. Identifying cis- and trans-acting single-nucleotide polymorphisms controlling lymphocyte gene expression in humans. BMC Proc. 2007;1 Suppl 1:S7. Epub 2007 Dec 18.

Beyene J, Hu P, Parkhomenko E, Tritchler D. Impact of normalization and filtering on linkage analysis of gene expression data. BMC Proc. 2007;1 Suppl 1:S150. Epub 2007 Dec 18.

Parkhomenko E, Tritchler D, Beyene J. Genome-wide sparse canonical correlation of gene expression with genotypes.BMC Proc. 2007;1 Suppl 1:S119. Epub 2007 Dec 18.

Cordell HJ, de Andrade M, Babron MC, Bartlett CW, Beyene J, Bickeböller H, Culverhouse R, Cupples LA, Daw EW, Dupuis J, Falk CT, Ghosh S, Goddard KA, Goode EL, Hauser ER, Martin LJ, Martinez M, North KE, Saccone NL, Schmidt S, Tapper W, Thomas D, Tritchler D, Vieland VJ, Wijsman EM, Wilcox MA, Witte JS, Yang Q, Ziegler A, Almasy L, Maccluer JW. Genetic Analysis Workshop 15: gene expression analysis and approaches to detecting multiple functional loci. BMC Proc. 2007;1 Suppl 1:S1. Epub 2007 Dec 18.

Sung L, Nathan P, Alibhai S, Tomlinson G, Beyene J. Meta-analysis: Effect of prophylactic hematopoeitic colony - stimulating factors on mortality and outcomes of infection. Ann Intern Med 2007 Sept 18; 147(6):400-11.

Rujkijyanont P, Beyene J, Wei K, Khan F, Dror Y. Leukemia-related gene expression in bone marrow cells from patients with the preleukemic disorder shwachman-diamond syndrome. British Journal of Haematology, 2007 Jun;137(6):537-44.

Jamal SA, Hayden JA, Beyene J. Low Bone Mineral Density and fractures in long-term hemodialysis patients: a meta-analysis. American Journal of Kidney Diseases, 2007 May; 49(5):674-81.

O’Brodovich H, Beyene J, Tallett S, MacGregor D, Rosenblum ND. Performance of a career development and compensation program at an academic health science centre. Pediatrics, 2007 April; 119(4):e791-7.

Friedrich JO, Adhikari N, Beyene J. Inclusion of zero total event trials in meta-analyses maintains analytic consistency and incorporates all available data. BMC Medical Research Methodology, 2007 Jan 23;7:5.

Beyene J, Tritchler D, Bull SB, Cartier KC, Jonasdottir G, Kraja AT, Li N, Nock NL, Parkhomenko E, Rao JS, Stein CM, Sutradhar R, Waaijenborg S, Wang KS, Wang Y, Wolkow P. Multivariate analysis of complex gene expression and clinical phenotypes with genetic marker data. Genet Epidemiol. 2007; 31 Suppl 1:S103-9.

Hu P, Greenwood CMT, M'lan E, Beyene J. Chromosomal clustering of periodically expressed genes in plasmodium falciparum. Methods of Microarray Data Analysis V (CAMDA2004). McConnell P, Lin SM, Hurban P (Eds). Springer, 2007, pp. 103-119.

Labbe A, McClintick J, Martinez M, Beyene J, Chen L, de Andrade M, Edenberg HJ, Kim Y, Liu KY, Liu Y, Ma J, Peng B, Peng J, Peralta JM, Qin S, Roth MP, Wang P. Summary of contributions to GAW15 Group 16: processing/normalization of expression traits. Genet Epidemiol. 2007; 31 Suppl 1:S132-8.

2006

Manca A, Willan AR. Lost in translation: accounting for between country differences in the analysis of multinational cost effectiveness data. Pharmacoeconomics 2006; 24:1101-1119.

Willan AR, Briggs AH. The Statistical Analysis of Cost-effectiveness Data. Chichester UK: Wiley 2006.

Willan AR. Statistical analysis of cost-effectiveness data from randomized clinical trials. Expert Rev. Phamacoeconomics Outcomes Res 2006; 6:337-346.

Willan AR, Goeree, R, Pinto EM, McBurney C, Blackhouse G. Economic evaluation of rivastigmine.

Song P.X.K., Gao X., Liu R., and Le, W. Nonparametric inference for local extrema with application to oligonucleotide microarray data in yeast genome. Biometrics 2006; 62 (2): 545 – 554.

Oepkes D, Seaward G, Vandenbussche F, Windrim R, Kingdom J, Beyene J, Kanhai H, Ohlsson A, Ryan G, For The Diamond Study Group. Doppler ultrasonography compared to amniotic fluid deltaOD450 in the prediction of fetal anemia in rh-alloimmunized pregnancies. New England Journal of Medicine. 2006 Jul 13; 355(2):156-64.

Shah PS, Beyene J, To T, Ohlsson A, Perlman M. Postasphyxial hypoxic - ischemic encephalopathy in neonates: outcome prediction rule within first four hours of birth. Arch Pediatr Adolesc Med. 2006 Jul; 160(7):729-36.Leung EW, Rujkijyanont P, Beyene J, Wei K, Abdelhaleem M, Freedman MH, Dror Y. Shwachman-Diamond syndrome: an inherited model of aplastic anaemia with accelerated angiogenesis. Br J Haematol 2006 Jun; 133(5):558-61.

Sung L, Beyene J, Hayden J, Nathan PC, Lange B, Buchanan G, Tomlinson GA. A Bayesian meta-analysis of prophylactic granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor in children with cancer. Am J Epidemiol. 2006 May 1; 163(9): 811-7.

Hu P, Beyene J, Greenwood CMT. Tests for differential gene expression using weights in oligonucleotide microarray experiments. BMC Genomics, 2006; 22;7(1):33.

Hu P, Greenwood CMT, Beyene J. Integrative analysis of gene expression data including an assessment of pathway enrichment for predicting prostate cancer. Cancer Informatics, 2006; 2:289-300.

Hu P, Greenwood CMT, Beyene J. Statistical methods for meta-analysis of microarray data: a comparative study. Information Systems Frontiers; Special Issue on Knowledge Discovery in High Throughput Biological Domains; 2006:8:9-20.