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Drugs and Breastfeeding

Who We Are

Photo of Dr. Shinya Ito

Dr. Shinya Ito, MD, FRCPC
Division Head, Clinical Pharmacology & Toxicology, Department of Paediatrics
Senior Scientist, Translational Medicine, The Hospital for Sick Children

Dr. Shinya Ito is the Principal Investigator of the DLAC project. He is a clinician-scientist at SickKids and an attending physician in the paediatric drug consultation service and the DART (Drug Allergy Reaction & Toxicology) clinic. Dr. Ito’s research is mainly focused on mechanisms of drug transport in breast milk and long-term side effects of drugs on children including how genes influence drug responses (pharmacogenomics). 


Photo of Dr. Lusia Sepiashvili

Dr. Lusia Sepiashvili, PhD, DABCC, FCACB
Clinical Biochemist, Department of Paediatric Laboratory Medicine, The Hospital for Sick Children
Assistant Professor, University of Toronto

Dr. Lusia Sepiashvili (co-investigator) is a clinical biochemist at The Hospital for Sick Children where she acts as a scientific resource and provides oversight over various sections of the Clinical Biochemistry Division as part of the Department of Paediatric Laboratory Medicine. Dr. Sepiashvili has diverse academic interests in the field of clinical chemistry. She is interested in translating new lab tests from research into clinical use and applying novel technologies to advance the clinical utility of lab tests and their throughput. Furthermore, she enjoys collaborating with clinical colleagues on laboratory quality improvement and lab test utilization projects.

Prior to her current role, she completed a post-doctoral fellowship in clinical chemistry at the Mayo Clinic, Rochester.  Her research during her fellowship was geared towards advancing novel diagnostic techniques and biomarkers into clinical use and improving quality of clinical lab tests. Furthermore, she has developed research interests in a number of diverse areas in clinical chemistry, including immunology, endocrinology, and autoimmunity. She also further advanced her expertise in clinical mass spectrometry, building on her experience from doctoral studies at the University of Toronto that focused on translational cancer proteomics.


Photo of Dr Andrea Edington

Dr. Andrea Edginton, PhD
Associate Professor, Programmatic Assesment Officer, University of Waterloo

Dr. Andrea Edginton’s research focuses on the development and application of physiologically-based pharmacokinetic (PBPK) models and simulation techniques in both the areas of pharmaceuticals and human health risk assessment. Her research examines how the physiology of sub-populations such as children and patients with disease (e.g. obesity, liver cirrhosis) affect the pharmacokinetics of drugs and how this information can be integrated into PBPK models for the optimization of drug therapy. Of special interest is the physiological scaling of evaluated PBPK models from adults to children as a means to predict drug pharmacokinetics and quantify appropriate dosing regimens for clinical trials in children. Evaluation techniques for large and small molecule PBPK models are also an area of research.


Photo of Pooja Dalvi

Pooja Dalvi, M.Sc.
Clinical Research Project Coordinator, Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children

Pooja has been working in clinical and biomedical research since 2008 in the fields of stem cell biology, clinical pharmacology and pharmacogenetics. She plays a key role in various clinical projects in which she is responsible for participant recruitment, obtaining and processing bio-specimens, validation of assays, quality control, data management and data integrity. Pooja interacts with the clinical study participants and regularly follows up with them to make sure that the participants successfully complete various research components. She monitors day-to day performance of research operations, study logistics and serves as principal administrative liaison for the projects.