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Guidos Lab
Guidos Lab

Publications

For a complete list of publications, see PubMed.

Selected Lymphocyte Development Publications

Suliman S, Tan J, Xu K, Kousis PC, Kowalski PE, Chang G, Egan S, Guidos CJ. (2011) Notch3 is dispensable for thymocyte β-selection and Notch1-induced T cell leukemogenesis. PLoS ONE 6(9) e24937. Senior Responsible Author

Yuan JS, Tan JB, Visan I, Matei IR, Urbanellis P, Xu K, Danska JS, Egan SE, Guidos CJ. (2011) Lunatic Fringe prolongs Delta/Notch induced self-renewal of committed αβ T-cell progenitors. Blood 117 (4): 1184-1195. Senior Responsible Author

Visan I, Yuan JS, Liu Y, Stanley P, Guidos CJ. (2010) Lunatic Fringe enhances competition for delta-like Notch ligands but does not overcome defective pre-TCR signaling during thymocyte β-selection in vivo. Journal of Immunology 185 (8): 4609-4617. Senior Responsible Author

Tan JB, Xu K, Cretegny K, Visan I, Yuan JS, Egan SE, Guidos CJ. (2009) Lunatic and manic fringe co-operatively enhance marginal zone precursor competition for delta-like-1 in splenic endothelial niches. Immunity 30, 254-263. (See also associated Preview in Immunity 30, 175-177). Senior Responsible Author

Visan I, Tan JB, Yuan JS, Harper JA, Koch U, Guidos CJ (2006) Regulation of T lymphopoiesis by Notch1 and Lunatic fringe-mediated competition for intrathymic niches. Nat Immunol. 7(6):634-43

Visan I, Yuan JS, Tan JB, Cretegny K, Guidos CJ (2006) Regulation of intrathymc T cell development by Lunatic Fringe-Notch1 interactions. Immunol Rev. 209:76-94

Tan JB, Visan I, Yuan JS, Guidos CJ (2005) Requirement for Notch 1 signals at sequential early stages of intrathymic Tcell development. Nat Immunol. 6(7):671-9

Koch U, Yuan JS, Harper JA, Guidos CJ (2003) Fine-tuning Notch1 activation by endocytosis and glycosylation. Semin Immunol. 15(2):99-106 French MB, Koch U, Shaye RE, McGill MA, Dho SE, Guidos CJ, McGlade CJ (2002) Transgenic expression of Numb inhibits Notch signaling in immature thymocytes but does not alter T cell fate specification. J Immunol 168(7):3173-80

Selected Lymphoblastic Leukemia Publications

Matei IR, Gladdy RA, Nutter L, Guidos CJ, Danska JS. (2007) ATM disrupts TCR-alpha locus integrity and the maturation of CD4+CD8+ thymocytes. Blood. 109(5):1887-96

Guidos C (2006) Thymus and T-lymphocyte development: what is new in the 21st century? Immunol Rev. 209:5-9

Matei IR, Guidos CJ, Danska JS (2006) ATM-dependent DNA damage surveillance in T-cell development and leukemogenensis: the DSB connection. Immunol Rev. 209:142-58

Gladdy RA, Taylor MD, Williams CJ, Grandal I, Karaskova J, Squire JA, Rutka JT, Guidos CJ, Danska JS. (2003) p53-independent apoptois disrupts early organogenesis in embryos lacking both ataxa-telangiectasia mutated and Prkdc The RAG-1/2 endonuclease causes genomic instability and controls CNS complications of lymphoblastic leukemia in p53/Prkdc-deficient mice. Cancer Cell. 3(1):37-50.

Gladdy RA, Taylor MD, Williams CJ, Grandal I, Karaskova J, Squire JA, Rutka JT, Guidos CJ, Danska JS. (2003) The RAG-1/2 endonuclease causes genomic instability and controls CNS complications of lymphoblastic leukemia in p53/Prkdc-deficient mice. Cancer Cell. 3(1):37-50

Williams CJ, Grandal I, Vesprini DJ, Wojtyra U, Danska JS, Guidos CJ. (2001) Irradiation promotes V(D)J joining and RAG-dependent neoplastic transformation in SCID T-cell precursors. Mol Cell Biol. 21(2):400-13 Danska JS, Holland DP, Mariathasan S, Williams KM, Guidos CJ. (1996) Biochemical and genetic defects in the DNA-dependent protein kinase in murine scid lymphocytes. Mol Cell Biol. 16(10):5507-17 Guidos CJ, Williams CJ, Grandal I, Knowles G, Huang MT, Danska JS. (1996) V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors. Genes Dev. 10(16):2038-54

Danska JS, Pflumio F, Williams CJ, Huner O, Dick JE, Guidos CJ. (1994) Rescue of T cell-specific V(D)J recombination in SCID mice by DNA-damaging agents. Science. 266(5184):450-5