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Guidos Lab
Guidos Lab

Research Projects

Functions of Notch-Fringe Interactions in Lymphocyte Development and Homeostasis

Signaling through several distinct Notch receptors critically regulates lymphocyte development and homeostasis. A hallmark of the Notch pathway is its gene dosage sensitivity, such that small differences in the amount of Notch activity can cause aberrant cell fate choices and T-cell leukemia. Fringe proteins are glycosyltransferases that modulate Notch sensitivity to Delta versus Serrate/Jagged ligands in order to restrict Notch activation to discrete times and micro-environmental niches in a variety of developing tissues. The long-term goal of this project is to to identify the functions of Notch signaling in the immune system, and to elucidate how Fringe proteins regulate Notch signaling is regulated to ensure proper immune function.

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Subversion of Survival and Developmental Pathways in Acute Lymphoblastic Leukemia:

(joint projects of Drs. Jayne Danska and Cynthia Guidos)

How do normal hematopoietic cells become abnormal leukemic stem cells? These mechanisms are currently poorly understood, and reflect multiple genetic alterations that perturb proliferation, differentiation, programmed cell death, and self-renewal pathways. The major objective of Drs. Danska and Guidos research program is to understand these disrupted molecular pathways and position this information within the cellular and developmental context of leukemogenesis.

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