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N-PhenoGENICS

Study Summary

The name of this research study, “N-PhenoGENICS,” stands for the study’s full name: "Neurocognitive-Phenome, Genome, Epigenome and Nutriome In Childhood Leukemia Survivors. "

Side effects of acute lymphoblastic leukemia treatment may occur in many organs including the brain.  Patients experiencing side effects involving the brain may have difficulties with concentrating and with their school subjects even after the treatment ends. These seem to be common consequences of the treatment and can be debilitating because the outcome of their academic and social difficulties may affect the child’s potential. These symptoms may vary from more to less severe among patients. 

Almost 25 per cent of childhood leukemia survivors who received chemotherapy have signs of these central nervous system side effects. In this research study we refer to these side effects as TRANCE (Treatment-Related late Adverse Neuro-Cognitive Effects). The reasons for the appearance of the TRANCE side effects are not known. We think that the severity of the side effect depends on differences in patient’s genes, which carry information that helps make us who we are, and environmental factors, such as what food we eat. If we identify the genes and the environmental factors, then we may be able to come up with a plan for treatment and prevention of these brain side effects and possibly improve the quality of life after diagnosis and treatment.