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Rovet Lab

Studies in progress

Memory and Thyroid Hormone Imaging Study (MATHIS)

Memory and Thyroid Hormone Imaging Study (MATHIS)

Purpose: To evaluate hippocampal structure and function in children with thyroid hormone insufficiencies during pregnancy and early life

Subjects: Four groups aged 10-14 years: children with congenital hypothyroidism, offspring of hypothyroid women, children with hypothyroxinemia of prematurity, and typically developing controls. Approximately 100 children will participate.

Approach: All children will receive an extensive battery of memory tests and will undergo structural and functional MRI scans. Structural measurements of hippocampus will include volumetrics, voxel based morphometry, magnetic resonance spectroscopy, and diffusion tensor imaging are being determined. All results will be correlated with findings from memory tests. Functional MRI tests will include measures known to tap hippocampus: autobiographic memory, word pairs test, object-place associations tests.

Status: Testing is currently underway

Funding Source: Canadian Institutes of Health Research


Thyroid, Imaging, and Visual Abilities Study (TIVA)

Thyroid, Imaging, and Visual Abilities Study (TIVA)

Purpose: To evaluate the visual pathways in children born preterm or with congenital hypothyroidism

Subjects: Three groups aged 10-14 years: children with low-risk prematurity whose thyroid hormone levels were assessed following birth, children with congenital hypothyroidism, and typically developing controls. Approximately 75 children will participate.

Approach: All children will receive an extensive battery of visuospatial tests and will undergo structural and functional MRI scans. Structural measurements of visual pathways will include volumetrics of relevant structures, voxel based morphometry, magnetic resonance spectroscopy, and diffusion tensor imaging. All results will be correlated with findings from visuospatial tests. Functional MRI tests will include measures known to tap dorsal or ventral visual pathways.

Status: About to begin

Funding Source: March of Dimes (U.S.)


Children's Autobiographical Memory Interview Study (CAMI)

Children's Autobiographical Memory Interview Study (CAMI)

Purpose: To study the development of autobiographical memory in typically and atypically developing children

Subjects: Typically developing children aged 8-16 years and children with congenital hypothyroidism.

Approach: All children receive the CAMI as well as the Everyday Memory and Morningness/Eveningness questionnaires. CAMI results are analyzed for semantic and episodic memories of specific events and are related to questionnaire findings.

Status: Interviews conducted and being analyzed on over 200 typically developing children

Funding Source: Canadian Institutes of Health Research