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Technology Assessment at SickKids

Publications

Bashir N, Ungar WJ. The 3-I Framework: A framework for developing public policies regarding pharmacogenomics (PGx) testing in Canada. Genome, 58(12): 527-540, 2015. doi 10.1139/gen-2015-0100  

Ungar WJ, Hadioonzadeh A, Najafzadeh M, Tsao NW, Dell S, Lynd LD. Parents and adolescents preferences for asthma control: A best-worst scaling choice experiment using an orthogonal main effects design. BMC Pulmonary Medicine, Nov 17;15:146. 2015, doi: 10.1186/s12890-015-0141-9..

Ungar WJ. Next generation sequencing and health technology assessment in autism spectrum disorder. Canadian Journal of Child and Adolescent Psychiatry, 24(2): 123-127, 2015 (featured on journal cover).

Burnett HF, Lambley R, West SK, Ungar WJ, Mireskandari, K. Cost-effectiveness analysis of clinic-based chloral hydrate sedation versus general anaesthesia for paediatric ophthalmological procedures. British Journal of Ophthalmology, 99:1565-1570, 2015, doi:10.1136/bjophthalmol-2015-306604

Lipstein EA, Brinkman WB, Fiks AG, Hendrix KS, Kryworuchko J, Miller VA, Prosser LA, Ungar WJ, Fox D. An emerging field of research:  Challenges in pediatric decision making. Medical Decision Making, 35:403-408, 2015, doi: 10.1177/0272989X14546901

Schuh S, Freedman S, Coates A, Allen U, Parkin P, Stephens D, Ungar W, Da Silva Z, Willan A. Impact of oximetry on hospitalization in bronchiolitis - a randomized trial. JAMA, 312(7):712-718, 2014, doi:10.1001/jama.2014.8637.

Burnett HF, Tanoshima R, Chandranipapongse W, Madadi P, Ito S, Ungar WJ. Testing for thiopurine methyltransferase status for safe and effective administration of thiopurines: A systematic review of clinical guidance documents.  The Pharmacogenomics Journal, 14(6):493-502, 2014, doi:10.1038/tpj.2014.47  

Burnett HF, Ungar WJ, Regier DA, Feldman BM, Miller FA. Parent willingness-to-pay for biologic treatments in juvenile idiopathic arthritis. Value in Health, 17(8):830-837, 2014.

Ungar WJ, Hadioonzadeh A, Najafzadeh M, Tsao NW, Dell S, Lynd LD. Preferences for asthma control in parents and adolescents using a best-worst scaling experiment. Respiratory Medicine 108:842-851, 2014, dx.doi.org/10.1016/j.rmed.2014.03.014.

Regier DA, Watson V, Burnett H, Ungar WJ. Task complexity and response certainty in discrete choice experiments: An application to drug treatments for juvenile idiopathic arthritis. Journal of Behavioral and Experimental Economics, 50:40-49, 2014.  

Ungar WJ, Prosser LA, Burnett H. Values and evidence colliding: Health technology assessment in child health. Expert Review of Pharmacoeconomics and Outcomes Research, 13(4):417-419, 2013 (lead article).

Caulfield T, Evans J, McGuire A, McCabe C, Bubela T, Cook-Deegan R, Fishman J, Hogarth S, Miller FA, Raviskty V, Biesecker B, Borry P, Cho M, Carroll JC, Etchegary H, Joly Y, Kato K, Soo-Jin Lee S, Rothenberg K, Sankar P, Szego MJ, Ossorio P, Pullman D, Rousseau F, Ungar WJ, Wilson B. Reflections on the cost of “low-cost” whole genome sequencing: framing the health policy debate. PLoS Biology 11(11): e1001699. doi:10.1371/journal.pbio.1001699, 2013

Ungar WJ, Costa V, Burnett H, Feldman BM, Laxer RM. The use of biologic response modifiers in polyarticular-course juvenile idiopathic arthritis: A systematic review. Seminars in Arthritis and Rheumatism, 42(6):597-618, 2013.

Tsimicalis A, Stevens B, Ungar WJ, McKeever P, Greenberg M, Agha M, Guerriere D, Naqvi A, Barr R. A mixed method approach to describe the out-of-pocket expenses incurred by families of children with cancer. Pediatric Blood and Cancer, 60(3):438-445, 2013

Gauvreau C, Ungar WJ, Köhler JC, Zlotkin S. The use of cost-effectiveness analysis for pediatric immunization in developing countries. The Milbank Quarterly, 90(4):760-788, 2012

Ungar WJ. Understanding the value of information from pediatric clinical research. Pediatric Drugs, 14(5):295-297, 2012

Tsimicalis A, Stevens B, Ungar WJ, McKeever P, Greenberg M, Agha M, Guerriere D, Barr R, Naqvi A, Moineddin R. A prospective study to determine the costs incurred by families of children newly diagnosed with cancer in Ontario. Psycho-Oncology, 21(10):1113-1123, 2012

Kromm SK, Bethell J, Kraglund F, Edwards S, Laporte A, Coyte PC, Ungar WJ. Characteristics and quality of pediatric cost-utility analyses. Quality of Life Research, 21(8):1315-1325, 2012

Burnett HF, Regier DA, Feldman BM, Miller FA, Ungar WJ. Parents’ preferences for drug treatments in juvenile idiopathic arthritis: A discrete choice experiment. Arthritis Care & Research, 64(9):1382-1391, 2012

Ungar WJ, Boydell K, Dell S, Feldman BM, Marshall D, Willan A, Wright J. A parent-child dyad approach to the assessment of health status and health-related quality of life in children with asthma. PharmacoEconomics, 30(8):697-712, 2012

Hancock-Howard RL, Ungar WJ, Marshall D, Einarson A, Koren G. Public preferences for teratology counseling services: A discrete choice experiment. Birth Defects Research Part A: Clinical and Molecular Teratology, 94(7):532-539, 2012.

Woo G, Tomlinson G, Yim C, Lilly L, Therapondos G,  Wong DKH, Ungar WJ, Einarson TR, Sherman M, Heathcote EJ, Krahn M. Health state utilities and quality of life in patients with hepatitis B. Canadian Journal of Gastroenterology, 26(7):445-451, 2012.

Ungar WJ. Challenges in health state valuation in pediatric economic evaluation: are QALYs contraindicated? PharmacoEconomics, 29(8):641-652, 2011.

Donnan JR, Ungar WJ, Mathews M, Rahman P. Systematic review of thiopurine methyltransferase genotype and enzymatic testing strategies. Therapeutic Drug Monitoring, 33:192–199, 2011.

Donnan JR, Ungar WJ, Mathews M, Hancock-Howard RL, Rahman P. A cost effectiveness analysis of thiopurine methyltransferase testing for guiding 6-mercaptopurine dosing in children with acute lymphoblastic leukemia. Pediatric Blood & Cancer, 57:231-239, 2011.

Goeree R, Hopkins R, Marshall JK, Armstrong D, Ungar WJ, Goldsmith C, Allen C, Anvari M. Cost-utility of Laparoscopic Nissen Fundoplication versus proton pump inhibitors for gastro-esophageal reflux disease: A 3-year prospective randomized controlled trial and economic evaluation. Value in Health, 14:263-273, 2011

Ungar WJ, Costa V, Hancock-Howard RL, Feldman B, Laxer RM. Cost-effectiveness of biologics in polyarticular-course juvenile idiopathic arthritis patients unresponsive to disease modifying anti-rheumatic drugs. Arthritis Care & Research, January; 63(1):111–119, 2011

Ungar WJ (Editor). Economic Evaluation in Child Health. Oxford: Oxford University Press, 2010. http://www.oupcanada.com/catalog/9780199547494.html

Goh YI, Koren G, Ungar WJ, Economic evaluation in harm prevention: what are the special challenges? Part 7.3 Economic evaluation in Fetal Alcohol Spectrum Disorder, in Ungar WJ (ed) Economic Evaluation in Child Health. Oxford: Oxford University Press, 2010.

Costa V, Ungar WJ, Health technology assessment in child health, in Ungar WJ (ed) Economic Evaluation in Child Health. Oxford: Oxford University Press, 2010.

Khan U, Bogue C, Ungar WJ, Hilliard P, Blanchette V, Carcao, M, Doria AS. Cost-effectiveness analysis of different imaging strategies for diagnosis of hemophilic arthropathy. Haemophilia 16(2):322-32, 2010.  

Hancock-Howard RL, McMahon M, Menon-Nair A, Woo G, Aziza A, Laporte A, Nauenberg E, Connolly BL, Wales PW, Ungar WJ. Cost-effectiveness analysis of implantable venous access device insertion using interventional radiologic versus conventional operating room methods in pediatric patients with cancer. Journal of Vascular and Interventional Radiology, 21(5):677-84, 2010.

Yong JHE, Schuh S, Rashidi R, Vanderby S, Lau R, Laporte A, Nauenberg E, Ungar WJ. A cost-effectiveness analysis of omitting radiography in diagnosis of acute bronchiolitis. Pediatric Pulmonology 44(2):122-127, 2009.

Wan M, Doria A, Krahn M, Ungar WJ, Medina S, Sung L. Acute appendicitis in young children: cost-effectiveness of US versus CT in diagnosis--a Markov decision analytic model. Radiology, 250(2): 378-86, 2009.

Sharieff W, Zlotkin S, Ungar WJ, Feldman BM, Krahn M, Tomlinson G. The economics of preventing premature mortality and impaired cognitive development in children through home-fortification: A health policy perspective. International Journal of Technology Assessment and Health Care 24(3):303-311, 2008.

Han RK, Ungar WJ, Macarthur C. Cost effectiveness analysis of a proposed public health legislative/educational strategy to reduce tap water scald injuries in children. Injury Prevention, 13: 248-253, August 2007.

Polisena J, Tam S, Lodha A, Laporte A, Coyte PC, Ungar WJ. An economic evaluation of asthma action plans for children with asthma. Journal of Asthma, 44 (7):501-508, September 2007.

Wu R, Laporte A, Ungar WJ. Cost effectiveness of an electronic medication ordering and administration system in reducing adverse drug events. Journal of Evaluation in Clinical Practice, 13:440-448, 2007.

Motiwala S, Gupta S, Lilly M, Ungar WJ, Coyte PC. The cost-effectiveness of expanding Intensive behavioural intervention (IBI) to all autistic children in Ontario. Healthcare Policy, 1(2):135-151, 2006.

Doria AS, Amernic H, Dick P, Babyn P, Chait P, Langer J, Coyte PC, Ungar WJ. Cost-effectiveness analysis of weekday and weeknight or weekend shifts for assessment of appendicitis. Pediatric Radiology, 35(12):1186-95, 2005.

Piwko C, Lasry A, Alanezi K, Coyte PC, Ungar WJ. Economic evaluation of ondansetron versus dimenhydrinate for prevention of post-operative vomiting in children undergoing strabismus surgery. Pediatric Anesthesia, 15(9):755-761, 2005.

Kopach R, Sadat S, Galloway I, Coyte PC, Ungar WJ. A cost-effectiveness analysis of medical documentation alternatives. International Journal of Technology Assessment in Health Care, 21(1):126-131, 2005.

Carcao M, Ungar WJ, Feldman B. Cost-utility analysis in evaluating prophylaxis in haemophilia. Haemophilia, 10(Suppl 1):50-57, 2004.

Attard NJ, Wei X, Laporte A, Zarb GA, Ungar WJ. A cost minimization analysis of implant treatment in mandibular edentulous patients. International Journal of Prosthodontics, 16(3):271-276, 2003.