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Physiology & Exp. Medicine Research in Progress Seminar
Start date:
Wednesday, February 15, 2017

Kassner Lab

Trish Domi, Post Doctoral Research Fellow

Imaging the Impact of Stroke in Children Using Structural and Functional MRI

Stroke is an important cause of acquired neurological morbidity in children with motor deficits being the most common. These motor deficits typically affect one side of the body and lead to life long consequences in children. To improve outcomes it is important to understand the neural mechanisms that determine the degree of recovery of movement after stroke. The use of multimodal neuroimaging techniques is one approach that can help improve our understanding of the mechanisms underlying recovery patterns following childhood stroke. Towards this goal, my research involves the use of MR imaging techniques to understand the relationship among the extent of stroke-induced damage to the corticospinal tract, associated changes in brain activity, and motor recovery. 

Jackie Leung, Research Project Coordinator

Transfer function analysis of BOLD MRI measures of cerebrovascular reactivity in children with sickle cell disease

Analysis of CVR has traditionally relied on a simplistic linear model correlating the change in blood flow in the brain and a stimulus. This approach provides clinically relevant information about the capacity of cerebral blood flow to dilate and constrict. More recent developments using transfer function analysis (TFA) examine the temporal aspect of the blood flow response. Such parameters add an extra dimension CVR analysis and can improve its diagnostic value. Our study investigated the application of TFA on BOLD MRI measures in children with sickle cell disease, and compared them to healthy controls.

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