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Centre for Global Child Health

Dr. Daniel Roth awarded four-year grant from the Bill & Melinda Gates Foundation

Dr. Daniel Roth and colleagues have been awarded a $15 million USD grant from the Bill & Melinda Gates Foundation for the Synbiotics for the Early Prevention of Severe Infections in Infancy (SEPSIS) project. SickKids co-investigators include Drs. Lisa Pell, Diego Bassani, Shaun Morris, Eleanor Pullenayegum, Prakesh Shah and Phil Sherman. The project will build an adaptive research platform aimed at describing the early infant microbiome and assessing the safety and efficacy of interventions to prevent severe infections and promote growth during early infancy (0-60 days of age) in Dhaka, Bangladesh. The platform will include a large phase III randomized controlled trial to test the efficacy of a specific synbiotic (probiotic-prebiotic combination) formulation to prevent newborn sepsis. The research will be conducted in collaboration with numerous partners including the International Centre for Diarrheal Disease Research, Bangladesh (icddr,b) and Child Health Research Foundation (CHRF), both based in Dhaka, Bangladesh.