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Paediatric Laboratory Medicine

Amikacin

Clinical Significance

Amikacin is indicated in the short term treatment of serious gram negative infections (Pseudomonas, Escherichia coli). It is particularly useful with those strains resistant to most other aminoglycosides of choice when gentamicin resistance is suspected.

As with other aminoglycosides, there is a narrow margin between therapeutic effectiveness and toxicity. Amikacin should be used with caution in patients with impaired renal function. 

Toxic side effects may include: ototoxicity (hearing loss), neuromuscular blockage (muscle paralysis) and nephrotoxicity.

Test Name

Amikacin

Alternate Name/ Synonym

Amikin

Test Code

AMITR, AMIPK, AMISP

Drug Class

Antibiotics

Division

Therapeutic Drug Monitoring - TDM

Method

Abbott Architect ci4100

External Proficiency Testing

CAP

Turn Around Time

Daily (throughout the day)

Disease/Condition

Antibiotic

Specimen Type

Serum, Plasma (Heparin or Citrate)

Minimum Specimen Requirements

150 uL

Optimal Collection Time

Trough: 0 - 30 minutes prior to dose 
Peak: 30 - 60 minutes after finish

Storage/Transportation

4°C (transport with a cool pack if possible)

Approval is not required

CPT Codes

80150

Shipping and Contact Information

The Hospital for Sick Children
Rapid Response Laboratory
170 Elizabeth Street, Room 3642
Toronto, ON
M5G 2G3
Canada
Phone: 416-813-7200
Phone: 1-855-381-3212

Therapeutic Range

Trough: 2.5 - 10.0 mg/L 
Peak: 20 - 35.0 mg/L

Critical Values

Trough: >15 mg/L 
Peak: >40 mg/L