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Paediatric Laboratory Medicine

Gentamicin

Clinical Significance

Gentamicin and other aminoglycosides are potentially nephrotoxic. The risk of nephrotoxicity is greater in patients with impaired renal function and in those who receive high dosage or prolonged therapy. Neurotoxicity can occur in patients treated with gentamicin with or without preexisting renal damage. Aminoglycoside-induced neurotoxicity is usually irreversible. Gentamicin use is mainly restricted to the therapy of life-threatening infections and those for which a less toxic antimicrobial agent is ineffective. It is frequently used for the treatment of serious infections; particularly those due to Pseudomona aeruginosa, Enterobacter, Klebsiella, Serratia, Citrobacter, Staphylococcus, and other species. Measurement of gentamicin is used to monitor the serum concentration to assure adequate levels and to avoid potential toxic levels.

Test Name

Gentamicin

Alternate Name/ Synonym

Garamycin

Test Code

GENTR,GENPK,GENSP

Drug Class

Antibiotics

Division

Therapeutic Drug Monitoring - TDM

Method

Vitros Fusion 5.1

External Proficiency Testing

QMPLS, CAP

Turn Around Time

Daily (throughout the day)

Disease/Condition

Antibiotic

Specimen Type

Serum, Plasma (Heparin)

Minimum Specimen Requirements

150 uL

Optimal Collection Time

Trough: 0-30 minutes prior to dose 
Peak: 30-60 minutes after finish

Storage/Transportation

4°C (transport with a cool pack if possible)

Approval is not required

CPT Codes

80170

Shipping and Contact Information

The Hospital for Sick Children
Rapid Response Laboratory
170 Elizabeth Street, Room 3642
Toronto, ON
M5G 2G3
Canada
Phone: 416-813-7200
Phone: 1-855-381-3212

Therapeutic Range

Trough: ≤ 2.1 mg/L 
Peak: 5.0-10.0 mg/L

Critical Values

Trough: > 2.1 mg/L 
Peak: > 10.0 mg/L