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Paediatric Laboratory Medicine

Vancomycin

Clinical Significance

Vancomycin is a small glycoprotein (MW: 1450) derived from Norcardia Orientalis. Vancomycin is active against many gram positive bacteria and some gram negative cocci. Vancomycin is useful in the treatment of staphylococcal infections in patients who cannot receive or have failed to respond to the penicillins or cephalosporins. Vancomycin kills bacteria by inhibiting bacterial cell wall synthesis. It also damages the bacterial cell membrane and interferes with bacterial RNA synthesis. Vancomycin must be given intravenously as it is poorly absorbed when taken orally and may cause tissue necrosis if injected intramuscularly. Side effects include: flushing of the face, neck and body. Nephrotoxicity and ototoxicity may also occur.

Test Name

Vancomycin

Alternate Name/ Synonym

Vancocin

Test Code

VANTR,VANPK, VASNSP

Drug Class

Antibiotics

Division

Therapeutic Drug Monitoring - TDM

Method

Vitros Fusion 5.1

External Proficiency Testing

CAP
QMPLS

Turn Around Time

Daily (throughout the day)

Disease/Condition

Antibiotic

Specimen Type

Serum, K2EDTA Plasma

Minimum Specimen Requirements

150 uL

Optimal Collection Time

Trough: 0 - 30 minutes prior to dose 
Peak: 30 - 60 minutes after finish

Storage/Transportation

4°C (transport with a cool pack if possible)

Approval is not required

CPT Codes

80202

Shipping and Contact Information

The Hospital for Sick Children
Rapid Response Laboratory
170 Elizabeth Street, Room 3642
Toronto, ON
M5G 2G3
Canada
Phone: 416-813-7200
Phone: 1-855-381-3212

Therapeutic Range

Trough: 5.0 - 12.0 mg/L 
Peak: 25.0 - 40.0 mg/L

Critical Values

Trough: > 15.0 mg/L 
Peak: > 50.0 mg/L