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Paediatric Laboratory Medicine

Carbamazepine 10,11-Epoxide

Clinical Significance

Carbamazepine-10,11-epoxide has anticonvulsant activity similar to that of its parent compound, Carbamazepine. The half-life averages six hours. This heterocyclic (iminostilbene) compound has potent antiepileptic properties and is effective alone or with other antiepileptic drugs in controlling many type of seizures. Side effects may include: leukopenia and hyponatremia. Patients in the first month of pregnancy are at increased risk of neural tube defects.

Test Name

Carbamazepine 10,11-Epoxide

Test Code

EPOX

Drug Class

Anticonvulsants

Division

Therapeutic Drug Monitoring - TDM

Method

HPLC

External Proficiency Testing

UKEQAS
CAP

Turn Around Time

Daily @ 14:00h

Disease/Condition

Anticonvulsant

Specimen Type

Serum, Plasma (Heparin or Citrate)

Minimum Specimen Requirements

50 uL

Optimal Collection Time

Trough: 0 - 30 minutes prior to dose

Storage/Transportation

4°C (transport with a cool pack if possible)

Approval is not required

CPT Codes

80299

Shipping and Contact Information

The Hospital for Sick Children
Rapid Response Laboratory
170 Elizabeth Street, Room 3642
Toronto, ON
M5G 2G3
Canada
Phone: 416-813-7200
Phone: 1-855-381-3212

Therapeutic Range

5.0 – 12.0 umol/L