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Paediatric Laboratory Medicine

Primidone

Clinical Significance

Primidone is an anticonvulsant drug used primarily in the treatment of complex partial seizures and their secondary generalizations. Primidone is metabolized primarily in the liver. The major metabolite, phenylethylmalonamide has little anticonvulsant activity. The second metabolite, phenobarbital has potent anticonvulsant activity. Due to its long half life, patients on long term primidone therapy should also have the phenobarbital quantitation done along with the primidone. Primidone toxicity may occurr in patients with renal disease. Typical toxic symptoms may include confusion, dizziness, nystagmus and ataxia.

Test Name

Primidone

Alternate Name/ Synonym

Mysoline

Test Code

PRIMD

Drug Class

Anticonvulsants

Division

Therapeutic Drug Monitoring - TDM

Method

HPLC

External Proficiency Testing

CAP

Turn Around Time

Daily @ 14:00h

Disease/Condition

Anticonvulsant

Specimen Type

Serum, Plasma (Heparin or Citrate)

Minimum Specimen Requirements

150 uL

Optimal Collection Time

Trough: 0-30 minutes prior to dose

Storage/Transportation

4°C (transport with a cool pack if possible)

Approval is not required

CPT Codes

80188

Shipping and Contact Information

The Hospital for Sick Children
Rapid Response Laboratory
170 Elizabeth Street, Room 3642
Toronto, ON
M5G 2G3
Canada
Phone: 416-813-7200
Phone: 1-855-381-3212

Therapeutic Range

23-55 umol/L

Critical Values

>70 umol/L