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Paediatric Laboratory Medicine

Pentobarbital

Clinical Significance

Pentobarbital is an short acting barbiturate which depresses the central nervous system and induces hypnosis and anesthesia.  Recovery after a dose is rapid with some slow somnolence and antergrade amnesia.

Pentobarbital produces respiratory depression and hemodynamic effects including a decrease in systemic vascular resistance, arterial pressure, cardiac output and a fall in coronary perfusion pressure.  Symptoms of toxicity include: circulatory depression, arrhythmias, respiratory depression, bronchospasm, emergence delirium, prolonged somnolence and recovery, nausea.

Test Name

Pentobarbital

Alternate Name/ Synonym

Nembutal

Test Code

PENTOB

Drug Class

Sedative/Barbiturate

Division

Therapeutic Drug Monitoring - TDM

Method

GC / HPLC

Turn Around Time

Daily as required

Specimen Type

Plasma (Heparin or citrate)

Minimum Specimen Requirements

600 uL

Optimal Collection Time

Trough: 0 – 30 minutes prior to dose

Storage/Transportation

4°C (transport with a cool pack if possible)

Approval is not required

CPT Codes

82205

Shipping and Contact Information

The Hospital for Sick Children
Rapid Response Laboratory
170 Elizabeth Street, Room 3642
Toronto, ON
M5G 2G3
Canada
Phone: 416-813-7200
Phone: 1-855-381-3212

Critical Values

> 40 umol/L