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Paediatric Laboratory Medicine

Salicylate

Clinical Significance

Salicylates, sold as Aspirin or Acetylsalicyclic Acid (ASA), possess anti-inflammatroy, analgesic and antipyretic properties. They are available in many formulations including tablets, capsules, liquids and topical forms such as creams or lotions. Metabolism is primarily hepatic with renal elimination. In overdose situations a severe metabolic acidosis with a compensatory respiratory alkalosis may develop.

Central respiratory centre stimulation a hyperventilation a respiratory alkalosis Inhibition of Krebs Cycle enzymes & uncoupling of oxidative phosphorylation a metabolic acidosis which leads to a increase in glycolysis a hypoglycemia.

Alteration in capillary integrity a pulmonary and cerebral edema.

Alteration of platelet function and prolongation of prothrombin time Clinical symptoms of salicylate toxicity include: pulmonary, auditory (ototoxicity, tinnitus), cardiovascular (tachycardia, hypotension), neurologic (CNS depression, seizures), gastrointestinal (nausea, vomiting), genitourinary (renal failure), hematological and electrolyte disturbances (dehydration, hypokalemia, hypocalcemia & acidemia.

Test Name

Salicylate

Alternate Name/ Synonym

Aspirin, Acetylsalicylic Acid (ASA)

Test Code

FSALB

Drug Class

Analgesic

Division

Toxicology

Method

Abbott Architect ci4100

External Proficiency Testing

QMPLS, CAP

Turn Around Time

Daily, Stat

Specimen Type

Serum, Plasma (Heparin, Citrate or EDTA)

Minimum Specimen Requirements

150 uL

Optimal Collection Time

NA

Storage/Transportation

4°C (transport with a cool pack if possible)

Special Requirements

NA

Approval is not required

CPT Codes

80196

Shipping and Contact Information

The Hospital for Sick Children
Rapid Response Laboratory
170 Elizabeth Street, Room 3642
Toronto, ON
M5G 2G3
Canada
Phone: 416-813-7200
Phone: 1-855-381-3212

Therapeutic Range

Not detected

Critical Values

Refer to Done Nomogram