Facebook Pixel Code
Section banner image
Paediatric Laboratory Medicine

Alpha-Fetoprotein (AFP), Blood

Clinical Significance

The discovery of alpha-fetoprotein (AFP) in fetal serum was first recorded by Bergstrand and Czar in 1956.

Alpha-fetoprotein is a single polypeptide chain glycoprotein with a molecular weight of approximately 70,000 daltons. It is secreted into fetal serum, reaching a peak at about 13 weeks gestation and gradually declining thereafter. Elevated serum AFP levels subsequently reappear during pregnancy and in conjunction with several malignant diseases

Test Name

Alpha-Fetoprotein (AFP), Blood

Division

Biochemistry - Biochemistry

Method

Abbott Ci4100

External Proficiency Testing

CAP
QMPLS

Turn Around Time

Monday to Friday

Specimen Type

Serum, Sodium/Lithium Heparin / EDTA plasma, Amniotic fluid

Minimum Specimen Requirements

150 uL

Storage/Transportation

Frozen

Approval is not required

CPT Codes

82105

Shipping and Contact Information

The Hospital for Sick Children
Rapid Response Laboratory
170 Elizabeth Street, Room 3642
Toronto, ON
M5G 2G3
Canada
Phone: 416-813-7200
Phone: 1-855-381-3212

Reference Range

Age

Range (µg/L)

0 – < 1m

100 – 10,000

1 – < 3m

10 – 1359

3 – < 6m

4 – 275

6 – < 12 m

3 – 148

1 – < 3y

3 – 21

3  – < 19y

1 – 4