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Paediatric Laboratory Medicine

Androstenedione, Blood

Clinical Significance

Androstenedione (4-Androstene-3, 17-dione), a 19 carbon steroid, is produced in the adrenal gland and gonads. It is an immediate precursor to both testosterone and estrone, both of which may be subsequently converted to estradiol. Androstenedione is a weak androgen and its physiologic role is not well defined. Serum androstenedione levels are high in fetus and neonates, decrease during childhood and increase at puberty. In normal pubertal and adult male, the major portion of androstenedione derives from the testis, either directly or from conversion of testosterone, while in pubertal and adult female, androstenedione is essentially produced by the adrenal gland and ovary. Androstenedione may play a role in the development of secondary sexual hair during adrenarche. Adrenal androstenedione production gradually declines with advanced age in both male and female. Ovarian androstenedione production is stimulated by luteinizing hormone and varies with the menstrual cycle and decreases after menopause.

Test Name

Androstenedione, Blood

Test Code

SPAND

Division

Biochemistry - Biochemistry

Method

LC-MS/MS

External Proficiency Testing

CAP,IQMH,SKML (Foundation for Quality Assessment in Medical Laboratories)

Turn Around Time

Tuesday & Thursday

Specimen Type

Serum or Plasma

Minimum Specimen Requirements

500 uL

Storage/ Transportation: Frozen

Approval is not required

CPT Codes

82157

Shipping and Contact Information

The Hospital for Sick Children
Rapid Response Laboratory
170 Elizabeth Street, Room 3642
Toronto, ON
M5G 2G3
Canada
Phone: 416-813-7200
Phone: 1-855-381-3212

Reference Range

Female

Age

Range (nmol/L)

0 – <14d

0.0 – 2.5

14d – <1y

0.1 – 2.1

1 – <6y

0.1 – 0.6

6 – <10y

0.2 – 0.9

10 – <12y

0.0 – 2.5

12 – <15y

0.7 – 6.0

15 – <19y

0.5 – 6.5

Adult

See attachment

Male

Age

Range (nmol/L)

0 – <14d

0.0 – 2.5

14d – <1y

0.1 – 2.1

1 – <6y

0.1 – 0.6

6 – <10y

0.2 – 0.9

10 – <12y

0.0 – 2.5

12 – <15y

0.5 – 2.0

15 – <19y

0.9 – 3.6

Adult

See attachment