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Paediatric Laboratory Medicine

DHEA-S, Blood

Clinical Significance

Dehydroepiandrosterone sulfate (DHEA-S) is the most abundant adrenal androgen and also functions as a neurosteroid that is produced by the adrenal cortex. DHEA-S is an excellent indicator of adrenal androgen production. DHEA-S exhibits only weak androgenic activity but can be metabolized to more active androgens such as testosterone and androstenedione. Serum concentrations decline with age and can serve as a prognostic factor in both critical illnesses and breast cancer progression. Elevated levels of DHEA-S are found in the plasma of patients with adrenal tumors or congenital adrenal hyperplasia. DHEA-S may also be slightly elevated in patients with polycystic ovaries. Tumors in men that produce hCG may lead to increased levels of testicular DHEA-S.

Test Name

DHEA-S, Blood

Test Code

DHA

Division

Biochemistry - Biochemistry

Method

Abbott Ci4100

External Proficiency Testing

CAP
QMPLS

Turn Around Time

Monday to Friday

Specimen Type

Serum, K EDTA / Na Citrate / Na Heparin Plasma

Minimum Specimen Requirements

150 uL

Storage/Transportation

Frozen

Approval is not required

CPT Codes

82626

Shipping and Contact Information

The Hospital for Sick Children
Rapid Response Laboratory
170 Elizabeth Street, Room 3642
Toronto, ON
M5G 2G3
Canada
Phone: 416-813-7200
Phone: 1-855-381-3212

Reference Range

<7d : 0.7-8.2 µmol/L (Male & Female)
7d-29d : 0.2-8.6 µmol/L (Male & Female)
1m-11m : 0.9-5.8 µmol/L (Male & Female)
1-4y : 0.9-7.5 µmol/L (Male & Female)
5-10y : 0.7-5.7 µmol/L (Male & Female)
11-14y : 0.5-6.6 µmol/L (Male)
11-14y : 0.2-4.6 µmol/L (Female)
15-19y : 1.2-10.4 µmol/L (Male)
15-19y : 1.7-13.4 µmol/L (Female)