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Paediatric Laboratory Medicine

Detection of MLL-AF4 fusion gene; t(4;11) (q22;q23)

Clinical Significance

Chromosomal translocations involving the MLL gene located on 11q23 are implicated in various types of  acute lymphocytic leukemia and acute myeloid leukemia. MLL-AF4 fusion gene; t(4;11) (q22;q23) is one of the common translocations seen in infant leukemia.

Test Name

Detection of MLL-AF4 fusion gene; t(4;11) (q22;q23)

Gene Name

  • MLL-AF4 fusion gene

Division

Haematopathology- Molecular Haematology

Method

RT PCR (Real-time polymerase chain reaction) (end point)

External Proficiency Testing

CAP

Turn Around Time

2-3 working days

Disease/Condition

AML (Acute myeloid leukemia)

Specimen Type

Peripheral Blood, Bone Marrow Aspirate

Minimum Specimen Requirements

2 mL

Storage/Transportation

Room Temperature (on ice if shipping takes more than 48 hrs).

Special Requirements

Sample to be collected in EDTA or Sodium citrate (preservative). Please call Laboratory prior to shipping your samples.

Shipping and Contact Information

The Hospital for Sick Children
Rapid Response Laboratory
170 Elizabeth Street, Room 3642
Toronto, ON
M5G 2G3
Canada
Phone: 416-813-7200
Phone: 1-855-381-3212