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Paediatric Laboratory Medicine

Detection of CBFB-MYH11 fusion gene; Inv(16)(p13.q22) or t(16;16) (p13;q22)

Clinical Significance

CBFB-MYH11 fusion gene is detected in acute myelomonocytic leukemia with Inv(16)(p13.q22) or t(16;16) (p13;q22) chromosomal translocations. This subtype of AML is usually associated with abnormal eosinophils in the bone marrow.

Test Name

Detection of CBFB-MYH11 fusion gene; Inv(16)(p13.q22) or t(16;16) (p13;q22)

Gene Name

CBFB-MYH11 fusion gene

Division

Haematopathology- Molecular Haematology

Method

RT PCR (Real-time polymerase chain reaction) (end point)

External Proficiency Testing

CAP

Turn Around Time

2-3 working days

Disease/Condition

AML (Acute myeloid leukemia)

Specimen Type

Peripheral Blood, Bone Marrow Aspirate

Minimum Specimen Requirements

2 mL

Storage/Transportation

Room Temperature (on ice if shipping takes more than 48 hrs).

Special Requirements

Sample to be collected in EDTA or Sodium citrate (preservative) Please call Laboratory prior to shipping your samples.

Shipping and Contact Information

The Hospital for Sick Children
Rapid Response Laboratory
170 Elizabeth Street, Room 3642
Toronto, ON
M5G 2G3
Canada
Phone: 416-813-7200
Phone: 1-855-381-3212