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Paediatric Laboratory Medicine

Detection of PML-RARA fusion gene; t(15;17) (q22;q21)

Clinical Significance

PML-RARA fusion gene is detected in greater than 99% of cases of acute promyelocytric leukemia (APL) which is associated with a favorable prognosis.

Test Name

Detection of PML-RARA fusion gene; t(15;17) (q22;q21)

Gene Name

  • PML-RARA fusion gene


Haematopathology- Molecular Haematology


RT PCR (Real-time polymerase chain reaction) (end point)

External Proficiency Testing


Turn Around Time

2-3 working days


AML (Acute myeloid leukemia)

Specimen Type

Peripheral Blood, Bone Marrow Aspirate

Minimum Specimen Requirements

2 mL


Room Temperature (on ice if shipping takes more than 48 hrs).

Special Requirements

Sample to be collected in EDTA  or Sodium citrate(preservative) Please call Laboratory prior to shipping your samples.

Shipping and Contact Information

The Hospital for Sick Children
Rapid Response Laboratory
170 Elizabeth Street, Room 3642
Toronto, ON
M5G 2G3
Phone: 416-813-7200
Phone: 1-855-381-3212