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Paediatric Laboratory Medicine

Detection of ETV6-RUNX1 (TEL-AML1); t(12;21)(p13;q22)

Clinical Significance

ETV6-RUNX1 (TEL-AML1) fusion gene associated with t(12;21)(p13;q22) is the most  frequent chromosomal rearrangement in childhood precursor B acute lymphocytic leukemia. The presence of this fusion transcript is associated with a favorable prognosis.

Test Name

Detection of ETV6-RUNX1 (TEL-AML1); t(12;21)(p13;q22)

Gene Name

ETV6-RUNX1 fusion gene

Alternate Gene Name

TEL-AML1

Division

Haematopathology- Molecular Haematology

Method

RT PCR

Turn Around Time

2-3 working days

Disease/Condition

ALL (Acute lymphocytic leukemia)

Specimen Type

Peripheral Blood, Bone Marrow Aspirate

Minimum Specimen Requirements

2 mL

Storage/Transportation

Room Temperature (on ice if shipping takes more than 48 hrs).

Special Requirements

Sample to be collected in EDTA  or Sodium citrate(preservative) Please call Laboratory prior to shipping your samples

Shipping and Contact Information

The Hospital for Sick Children
Rapid Response Laboratory
170 Elizabeth Street, Room 3642
Toronto, ON
M5G 2G3
Canada
Phone: 416-813-7200
Phone: 1-855-381-3212