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Paediatric Laboratory Medicine

Detection of BCR-ABL1; t(9;22) (q34;q11)

Clinical Significance

BCR-ABL1 p190 fusion gene is detected mostly in paediatric acute lymphocytic leukemia. The presence of this fusion gene is associated with unfavorable prognosis. BRC-ABL1 p210 fusion gene is detected in chronic myeloid leukemia and in acute myeloid leukemia and acute lymphocytic leukemia blast crisis phases of chronic myeloid leukemia.

Test Name

Detection of BCR-ABL1; t(9;22) (q34;q11)

Gene Name

  • BCR-ABL1 fusion gene

Division

Haematopathology- Molecular Haematology

Method

RT PCR (Real-time polymerase chain reaction) (end point)

Turn Around Time

2-3 working days

Disease/Condition

ALL (Acute lymphocytic leukemia), CML (Chronic myeloid leukemia), AML (Acute myeloid leukemia)

Specimen Type

Peripheral Blood, Bone Marrow Aspirate

Minimum Specimen Requirements

2 mL

Storage/Transportation

Room Temperature (on ice if shipping takes more than 48 hrs).

Special Requirements

Sample to be collected in EDTA or Sodium citrate(preservative) Please call Laboratory prior to shipping your samples

Shipping and Contact Information

The Hospital for Sick Children
Rapid Response Laboratory
170 Elizabeth Street, Room 3642
Toronto, ON
M5G 2G3
Canada
Phone: 416-813-7200
Phone: 1-855-381-3212