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Paediatric Laboratory Medicine

Detection of CALM-AF10; t(10;11)(p13;q14-21)

Clinical Significance

CALM-AF10 fusion gene; t(10;11)(p13;q14-21) is a recurring chromosomal abnormality that has been observed in  patients with acute lymphocytic leukemia , acute myeloid leukemia and acute megakaryoblastic leukemia.

Test Name

Detection of CALM-AF10; t(10;11)(p13;q14-21)

Gene Name

  • CALM-AF10 fusion gene

Division

Haematopathology- Molecular Haematology

Method

RT PCR (Real-time polymerase chain reaction) (end point)

Turn Around Time

2-3 working days

Disease/Condition

ALL (Acute lymphocytic leukemia), AML (Acute myeloid leukemia)

Specimen Type

Peripheral Blood, Bone Marrow Aspirate, 

Minimum Specimen Requirements

2 mL

Storage/Transportation

Room Temperature (on ice if shipping takes more than 48 hrs).

Special Requirements

Sample to be collected in EDTA or Sodium citrate (preservative) Please call Laboratory prior to shipping your samples

Shipping and Contact Information

The Hospital for Sick Children
Rapid Response Laboratory
170 Elizabeth Street, Room 3642
Toronto, ON
M5G 2G3
Canada
Phone: 416-813-7200
Phone: 1-855-381-3212