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Simple Bone Cyst in Kids

Simple Bone Cyst in Kids


Welcome to the official clinical trial website for Simple bone Cysts in Kids (SBoCK)! Whether you are a patient (or a parent, family member or guardian of a patient), a physician or a researcher, you will find information on:

  • What is a clinical trial?
  • What is SBoCK?
  • What do I do if I want to participate in SBoCK?

What is SBoCK?

SBoCK is a research trial initially developed at The Hospital for Sick Children (SickKids) in Toronto, Ontario, Canada. Together with our many participating hospitals, surgeons and researchers, we will treat approximately 160 patients with simple bone cysts. SBoCK is funded by a grant from the Canadian Institutes of Health Research (CIHR).

Who is in charge of SBoCK?

Dr. James G. Wright is an orthopaedic surgeon and an adjunct scientist at SickKids. He is the study chair and co-principal investigator of SBoCK. Dr. Sevan Hopyan is an orthopaedic surgeon, senior scientist and co-principal investigator of SBoCK. They will be assisted by co-investigators including Dr. Andrea S. Doria, Dr. Jennifer Stimec and Dr. Paul Babyn.

Why are you doing this trial?

Simple bone cysts are fluid filled cysts that sit in bones and are most frequently found in children. They can cause pain and/or fracture (break) a bone; therefore, patients and their families worry a lot about them. There are many ways to treat these cysts but we do not know if one way is better than another.

Wright, one of our principal investigators, and other surgeons at SickKids have written many articles over the years about the treatment of simple bone cysts. In addition, the first and only clinical trial to date on simple bone cysts was organized and led by Wright. The results demonstrated that steroid injections were more effective compared to bone marrow injections for cyst treatment and this led to a change in clinical practice.

The aforementioned trial, however, was completed over 10 years ago. As we now have new ways and devices to treat simple bone cysts, we feel it is important to conduct another trial to find out  the best way to remove these cysts and allow children to return to their normal activity as quickly as possible.

For journal articles related to simple bone cysts, please click the links below:

  • Donaldson S, Wright JG. Recent developments in treatment for simple bone cysts. Curr Opin Pediatr. 2011 Feb;23(1):73-7. Abstract
  • Canavese F, Wright JG, Cole WG, Hopyan S. Unicameral bone cysts: comparison of percutaneous curettage, steroid, and autologous bone marrow injections. J Pediatr Orthop. 2011 Jan-Feb;31(1):50-5. Abstract
  • Donaldson S, Chundamala J, Yandow S, Wright JG. Treatment for unicameral bone cysts in long bones: an evidence based review. Orthop Rev (Pavia). 2010 Mar 20;2(1):e13. Abstract
  • Wright JG, Yandow S, Donaldson S, Marley L; Simple Bone Cyst Trial Group. A randomized clinical trial comparing intralesional bone marrow and steroid injections for simple bone cysts. J Bone Joint Surg Am. 2008 Apr;90(4):722-30. Abstract
  • Norman-Taylor FH, Hashemi-Nejad A, Gillingham BL, Stevens D, Cole WG. Risk of refracture through unicameral bone cysts of the proximal femur. J Pediatr Orthop. 2002 Mar-Apr;22(2):249-54. Abstract
  • Hashemi-Nejad A, Cole WG. Incomplete healing of simple bone cysts after steroid injections. J Bone Joint Surg Br. 1997 Sep;79(5):727-30. Abstract