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International Replication Repair Deficiency Consortium

The International Replication Repair Deficiency Consortium (IRRDC) is a collaborative research initiative that aims to better understand and manage rare genetic conditions that result from the loss of DNA replication repair.

Collaborating with clinicians and scientists from more than 45 countries around the world, we focus on the study of Constitutional Mismatch Repair Deficiency Syndrome (CMMRD) - but our research extends to all replication repair deficiency syndromes, including paediatric Lynch Syndrome and Polymerase Proofreading-Associated Polyposis (PPAP). We also facilitate diagnosis through CLIA-approved testing at SickKids, Mount Sinai Hospital in Toronto and several other leading mismatch repair clinical laboratories in the world.

The IRRDC is centrally located in Toronto, Canada, as part of SickKids.

Contact us

The International Replication Repair Deficiency Consortium (IRRDC) welcomes all patients, families, researchers and health-care providers to join us. If you have any questions or want to refer a patient, please do not hesitate to contact us!

Phone: 416-813-7654 ext. 309115

International RRD Consortium
686 Bay Street
Room 17.9715
Toronto, ON
M5G 0A4

If you are a patient or health-care provider who suspects that one of their patients may have CMMRD, please also reach out to Dr. Uri Tabori ( and Dr. Vanessa Bianchi (

Associated clinics, divisions, and departments

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