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About Sickkids
About SickKids

Gail M. Annich, MD, MS, FAAP, FRCP(C)

The Hospital for Sick Children
Director of Quality and Safety
Critical Care Medicine

University of Toronto
Pediatric Critical Care Medicine

Phone: 416-813-7654 ext. 201835
Email: gail.annich@sickkids.ca
Alternate Contact: Sheila Mondonedo
Alternate Phone: 416-813-7654, Ext. 3282
Alternate Email: Sheila.mondonedo@sickkids.ca

Brief Biography

Gail Annich is a native of St. Paul, Alberta, Canada and graduated from the University of Alberta Medical School in 1988.  After completing her residency in paediatrics at the University of British Columbia 1993, she completed two fellowships in paediatric critical care medicine, the first at British Columbia Children's Hospital in 1994 and the second at The Hospital for Sick Children where she was also chief fellow in 1995. 

In 1995 she moved to Ann Arbor, Michigan to attend the University of Michigan for both an Extracorporeal Life Support Fellowship and also to embark upon a Masters of Science in Clinical Research Design/Statistical Analysis, both of which she completed in 1997.  In 1997, she joined the Pediatric Critical Care Faculty at C.S. Mott Children’s Hospital at the University of Michigan.  During her tenure at the University of Michigan, Dr. Annich was the Associate Director of ECMO program, the Director of the Pediatric ECMO Program,  Director of the CPR/Rapid Response Team for C.S. Mott Children’s Hospital and the Medical Director for the PICU.  

Her research field is in both Extracorporeal Life Support and blood/biomaterial compatibility and thrombogenicity for which she is published.  She is a core organizer for the annual Children’s National Symposium: ECMO and the Advanced Therapies for Respiratory Failure. In 2012 she was the senior editor for the 4th Edition of the ECMO textbook. Her passion is the clinical bedside care of critically ill patients and the teaching of this. In the past 7 years she has focused much of her teaching on simulation techniques and Mock Codes for which she received the Pediatric Faculty teaching award in 2012.  

In September of 2014, she finally returned home to resume the practice of paediatric critical care medicine here at The Hospital for Sick Children and take on the role of Director of Quality and Safety for the Department of Critical Care Medicine.

Academic Background

1986 Bachelor of Medical Science, University of Alberta
1988 Medical Doctor, University of Alberta  
1993 Pediatrics, University of British Columbia  
1994 Pediatric Critical Care Medicine, University of British Columbia  
1995 Pediatric Critical Care Medicine, The Hospital For Sick Children, University of Toronto
1997 Extracorporeal Life Support Fellowship, University of Michigan
1997 Masters of Science in Clinical Research Design/Statistical Analysis, University of Michigan


1. Annich, GM, Meinhardt, J. P., Mowery, K. A., Ashton, B. A., Merz, S. I., Hirschl, R. B., Meyerhoff, M. E., and Bartlett, R. H.: Reduced platelet activation and thrombosis in extracorporeal circuits coated with nitric oxide release polymers. Crit. Care Med. 28: 915-920, 2000.

2. Zhang H, Annich GM, Miskulin J, Osterholzer, K, Merz SI, Bartlett RH, Meyerhoff ME:  Nitric oxide releasing silicone rubbers with improved blood compatibility: Preparation, characterization, and In vivo evaluation. Biomaterials: Mar 2002; 23:6:1485-94.

3. Kolovos NS, Schuerer DJ, Moler FW, Bratton SL, Swaniker F, Bartlett RH, Custer JR, Annich GM:  Extracorporeal Life Support for Pulmonary Hemorrhage in Children: A Case Series.  Crit Care Med 30:577-580, 2002.

4. Bratton SB, Annich GM: Packed Red Blood Cell Transfusions for Critically Ill Pediatric Patients: When and For What Conditions: J Pediatr 2003: 142:95-7.

5. Zhang H., Annich GM., Miskulin J., Stankiewicz K., Osterholzer K., Merz SI, Bartlett RH, Meyerhoff ME: Nitric Oxide-Releasing Fumed Silica Particles: Synthesis, Characterization, and Biomedical Application. Journal of Analytical Chemistry 125: 17: 5015-5024, 2003.

6. Meinhardt JP, Annich GM, Miskulin J, Kawai T, Ashton BA, Bartlett RH: Thrombogenicity is not reduced when heparin and phospholipid bonded circuits are used in a rabbit model of extracorporeal circulation. ASAIO Journal 2003; 49:395-400.

7. Bhatt-Mehta V, Annich GM:  Sedative Clearance During Extracorporeal Membrane Oxygenation. Perfusion 20(6):309-15, 2005 Oct.

8. Fleming GM, Remenapp RT, Bartlett RH, Annich GM:  Hyperkalemia of the blood primed ECLS circuit does not result in post initiation hyperkalemia in infants <10 kg. Perfusion 21: 173-177, 2006 May.

9. Skrzypchak AM, Miskulin J,  Bartlett RH, Annich GM:  The Development of a Small Animal Model of Extracorporeal Circulation. ASAIO Journal 2006; (52) 3:396-402.

10. Zhou A, Annich GM, Wu Y, Meyerhoff ME:  Water-Soluble Poly(ethylenimine)-Based Nitric Oxide Donors:  Preparation, Characterization and Potential Application in Hemodialysis.  Biomacromolecules 7(9):2565-74, 2006 Sept.

11. Lafayette NG,  Skrzypchak AM, Merz S, Bartlett RH, Annich GM:  An In Vitro Method for Screening Short-term Nonthrombogenic Artificial Surfaces. ASAIO Journal 2007; (53) 2:159-162.

12. Skrzypchak AM, Lafayette NG, Zhou Z, Reynolds MM, Frost MC, Meyerhoff ME, Bartlett RH, Annich GM:  Effect of Varying Nitric Oxide Release to Prevent Platelet Consumption and Preserve Platelet Function in an In Vivo Model of Extracorporeal Circulation. Perfusion 2007 May; 22(3):193-200.

13. Cornell T, Wyrick, P, Fleming G, Pasko D, Han Y, Custer J, Haft J, Annich GM: The Use of Argatroban for Anticoagulation in Patients on Extracorporeal Circuits ASAIO Journal 2007; (53) 4:460-463.

14. Fleming GM, Gupta M, Cooley E, Remenapp R, Bartlett RH, Annich GM:  'Maintaining the standard: A quality assurance study for new equipment in the Michigan ECMO program.'  ASAIO Journal 2007; (53) 5:556-560.

15. Fleming GM, Cornell T, Welling T, Magee J, Annich, GM:  Hepatopulmonary Syndrome: Use of extracorporeal life support for life threatening hypoxia following liver transplantation.  Liver Transplantation 2008; (14) 7:966-70.

16. Fleming GM, Gurney JG, Donohue JE, Remenapp RT, Annich GM: Mechanical component failures in 28,171 neonatal and pediatric ECMO courses from 1987-2006. Pediatric Critical Care Medicine. 10(4):439-444, 2009.

17. Nardell K, Annich GM, Hirsch JC, Fahrner C, Brownlee P, King K, Fleming GM, Gajarski R: Determinants of Bleeding in Pediatric post-Cardiotomy Patients Requiring ECLS. Perfusion. 24(3):191-7, 2009 May.

18. Major T, Brant D, Reynolds M, Handa H, Bartlett RH, Meyerhoff ME, Annich GM: The Attenuation Of Platelet And Monocyte Activation In A Rabbit Model Of Extracorporeal Circulation By A Nitric Oxide Releasing Polymer. Biomaterials. 31(10):2736-45, 2010 Apr.

19. Gaffney AM., Wildhirt SM., Griffin MJ., Annich GM., Radomski MW., Extracorporeal Life Support [Review]  BMJ, 341:c5317, 2010.

20. Andreatta P, Saxton E, Thompson, M, and Annich GM:  "Simulation- based mock codes significantly correlate with improved pediatric patient survival rates".
Pediatr Crit Care Med. 2011 Jan;12(1):33-8.

21. Reynolds M, Annich GM:  The Artificial Endothelium [Review].  Organogenesis. 2011 Jan 1;7(1).

22. Hervey-Jumper S, Annich GM, Yancon A,  Garton HJ, Muraszko KM, Maher CO: Neurological complications of extracorporeal membranous oxygenation in children. Journal of Neurosurgery. Pediatrics. 7(4):338-44, 2011 Apr.

23. Custer JR, Annich GM: "A little patience for our patients; ECMO, eventually”  Crit Care Med, 13(1):94-96, 2012 Jan.

24. Amoako KA, Archangeli C,Handa H, Major T, Meyerhoff M, Annich GM, Bartlett RH. Thromboresistance Characterization of Extruded Nitric Oxide-Releasing Silicone Catheters. ASAIO Journal 2012; 58:1–10.

25. Gaffney AM, Wildhirt SM, Griffin MJ, Annich GM , Radomski MW. Extracorporeal life support. BMJ  2010;341:c5317.

26. Bembea MM, Annich GM, Rycus P, Oldenburg G, Berkowitz I, Pronovost P: Variability in anticoagulation management of patients on extracorporeal membrane oxygenation: an international survey Pediatric Critical Care Medicine. 14(2):e77-e84, February 2013.

27. Wagner D, Pasko D, Phillips K, Waldvogel J, Annich GM: In vitro Clearance of Dexmedetomidine in Extracorporeal Membrane Oxygenation. Perfusion January 2013; vol. 28, 1: pp. 40-46.

28. Kilbourn C, Gilogly A, Waldvogel J, Martin J, Annich GM, Wagner D: In vitro Clearance of Intravenous Acetaminophen in Extracorporeal Membrane Oxygenation. Perfusion March 2013 28: 141-145.

29. Kuo K, Cornell T, Shanley T, Odetola F, Annich GM: The Use of Extracorporeal Membrane Oxygenation in Sickle Cell Disease Perfusion. 2013 Sep;28(5):424-32.

30. Annich GM, Adachi I, MD: Anticoagulation for Pediatric Mechanical Circulatory Support. Pediatric Critical Care Medicine. 14(5):1-6, 2013.

31. MacLaren G, Dodge-Khatami A, Dalton HJ; Writing Committee, MacLaren G, Dodge-Khatami A, Dalton HJ, Adachi I, Almodovar M, Annich G, et al, Joint statement on mechanical circulatory support in children: a consensus review from the Pediatric Cardiac Intensive Care Society and Extracorporeal Life Support Organization. Pediatr Crit Care Med. 2013 Jun;14(5 Suppl 1):S1-2.

32. Handa H, Brisbois EJ, Major TC,  Refahiyat L, Amoako KA, Annich GM, Bartlett RH, Meyerhoff ME: In vitro and in vivo study of sustained nitric oxide release coating using diazeniumdiolate-doped poly(vinyl chloride) matrix with poly(lactide-co-glycolide) additive. J. Mater. Chem. B, 2013, 1, 3578

33. Major TC, Handa H, Brisbois EJ, Reynolds MM, Annich GM, Meyerhoff ME, Bartlett RH:  Nitric Oxide-Releasing Polymers Mediate Platelet Quiescence Via cGMP-Induced Serine 239 Phosphorylation of Vasodilator-Stimulated Phosphoprotein. Biomaterials. 2013 Nov;34(33):8086-96.

34. Long MT, Wagner D, Maslach-Hubbard A, Pasko D,  Baldridge P, Annich GM: Safety and efficacy of recombinant activated factor VII for refractory hemorrhage in pediatric patients on extracorporeal membrane oxygenation: a single center review. Perfusion. 2014 Mar;29(2):163-170.

35. Major TC, Brisbois EJ, Jones AM Zanetti ME, Annich GM, Bartlett, RH, Handa, H. Combination of direct thrombin inhibitor and antiplatelet, nitric oxide, for improved hemocompatibility in extracorporeal circulation, (in press for publication to Biomaterials)

36. Kawai Y, Cornell TT, Cooley EG, Beckman CN, Baldridge PK, Mottes, TA, Luckritz DO, Plomaritas K, Meade MM, Odetola FO, Han YY, Blatt NB, Annich GM. Therapeutic Plasma Exchange May Improve Hemodynamics and Organ Failure Among Children with Sepsis-Induced Multiple Organ Dysfunction Syndrome Receiving Extracorporeal Life Support (in press for Pediatric Critical Care Medicine).