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About Sickkids
About SickKids

Khosrow Adeli, PhD, FCACB, DABCC, FACB

The Hospital for Sick Children
Division Head
Clinical Biochemistry

Research Institute
Senior Associate Scientist
Molecular Medicine

University of Toronto
Professor
Departments of Biochemistry and Laboratory Medicine & Pathology


Phone: 416-813-8682
Fax: 416-813-6257
Email: khosrow.adeli@sickkids.ca

For more information, visit: Adeli Lab and www.caliperproject.ca

Research Interests

  • Molecular mechanisms of dyslipidemia
  • Lipoprotein metabolism
  • ApoB gene expression
  • Animal models of obesity and insulin resistance
  • Hyperlipidemia in insulin resistance and type 2 diabetes

Research activities

Molecular and Cellular Biology of Lipoprotein Metabolism in Insulin-Resistant States such as Obesity and Diabetes, and the link with Cardiovascular Disease

Dr. Adeli has been actively involved in both basic and clinical laboratory research since 1988 and has published over 200 articles and abstracts to date. His basic research program is focused on the link between insulin resistant diabetes and dysregulation of lipoprotein metabolism. His group has been elucidating the molecular mechanisms linking diet-induced insulin resistance and metabolic dyslipidemia. His laboratory is employing animal models of insulin resistance to investigate the molecular mechanisms mediating the diabetogenic effect of fructose-rich diets, mechanisms of fructose-induced hepatic insulin resistance, and pathways leading to hepatic and intestinal lipogenesis and lipoprotein dysregulation.

Development of a Paediatric Reference Interval Database for Disease Biomarkers

Dr. Adeli has also been spearheading a national initiative in collaboration with other pediatric health centres across Canada to establish a comprehensive database of pediatric reference intervals for laboratory biomarkers of pediatric disease. The new database will improve the clinical assessment, diagnosis, and monitoring of children and adolescents presenting with various medical concerns. The database has already been partially established and is available on the CALIPER project website (www.caliperproject.ca) as well as via a smartphone application on the Apple Store.

Publications

2017

Zhang J, Zamani M, Thiele C, Taher J, Amir Alipour M, Yao Z, Adeli K. AUP1 (Ancient Ubiquitous Protein 1) Is a key determinant of hepatic very-low-density lipoprotein assembly and secretion. arterioscler Thromb Vasc Biol. 2017Apr;37(4):633-642.

Cagman Z, Bingol Ozakpinar O, Cirakli Z, Gedikbasi A, Ay P, Colantonio D, Uras AR, Adeli K, Uras F. Reference intervals for growth arrest-specific 6 protein in adults. Scand J Clin Lab Invest. 2017 Apr;77(2):109-114.

Taher J, Farr S, Adeli K. Central nervous system regulation of hepatic lipid and lipoprotein metabolism. Curr Opin Lipidol. 2017 Feb;28(1):32-38.

2016

Tate JR, Koerbin G, Adeli K. Opinion Paper: Deriving harmonised reference intervals - Global Activities. EJIFCC. 2016 Feb 9;27(1):48-65.

Anderson LN, Maguire JL, Lebovic G, Hanley AJ, Hamilton J, Adeli K, McCrindle BW, Borkhoff CM, Parkin PC, Birken CS. Duration of fasting, serum lipids, and metabolic profile in early childhood. J Pediatr. 2016 Oct 11.

Raizman JE, Shea J, Daly CH, Karbasy K, Ariadne P, Chen Y, Henderson T, Redmond S, Silverman S, Moore AM, Adeli K. Clinical impact of improved point-of-care glucose monitoring in neonatal intensive care using Nova StatStrip: evidence for improved accuracy, better sensitivity, and reduced test utilization. Clin Biochem. 2016 Aug 1;49(12):879-84.

Loverdos I, Swan MC, Shekherdimian S, Al-Rasheed AA, Schneider R, Fish JS, Ngan BY, Adeli K, Lowe ME, Singh VP, Sevilla WM, Langer JC, Gonska T. A case of pancreatitis, panniculitis and polyarthritis syndrome: Elucidating the pathophysiologic mechanisms of a rare condition.J Pediatr Surg Case Rep. 2015 May;3(5):223-226.

Kelishadi R, Marateb HR, Mansourian M, Ardalan G, Heshmat R, Adeli K. Pediatric-specific reference intervals in a nationally representative sample of Iranian children and adolescents: the CASPIAN-III study. World J Pediatr. 2016 Aug 1;12(3):335-42.

Bashiri A, Nesan D, Tavallaee G, Sue-Chue-Lam I, Chien K, Maguire GF, Naples M, Zhang J, Magomedova L, Adeli K, Cummins CL, Ng DS. Cellular cholesterol accumulation modulates high fat high sucrose (HFHS) diet-induced ER stress and hepatic inflammasome activation in the development of non-alcoholic steatohepatitis. Biochim Biophys Acta. 2016 Apr 14:S1388-1981(16)30099.

Karbasy K, Lin DC, Stoianov A, Chan MK, Bevilacqua V, Chen Y, Adeli K. Pediatric reference value distributions and covariate-stratified reference intervals for 29 endocrine and special chemistry biomarkers on the Beckman Coulter immunoassay systems: a CALIPER study of healthy community children. Clin Chem Lab Med. 2016 Apr 1;54(4):643-57. 

Zamani M, Taher J, Adeli K. Complex role of autophagy in regulation of hepatic lipid and lipoprotein metabolism. J Biomed Res. 2016 Mar 3;30.

Farr S, Taher J, Adeli K. Central nervous system regulation of intestinal lipid and lipoprotein metabolism. Curr Opin Lipidol. 2016 Feb 1;27(1):1-7. 

Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L. Full list of authors Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016 Jan 1;12(1):1-222.

Ali SA, Al-Jazrawe M, Ma H, Whetstone H, Poon R, Farr S, Naples M, Adeli K, Alman BA. Regulation of cholesterol homeostasis by hedgehog signaling in osteoarthritic cartilage. Arthritis Rheumatol. 2016 Jan 1;68(1):127-37.

Higgins V, Chan MK, Nieuwesteeg M, Hoffman BR, Bromberg IL, Gornall D, Randell E, Adeli K. Transference of CALIPER pediatric reference intervals to biochemical assays on the Roche cobas 6000 and the Roche Modular P. Clin Biochem. 2016 Jan 1;49(1-2):139-49.