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About Sickkids
About SickKids

Khosrow Adeli, PhD, FCACB, DABCC, FACB

The Hospital for Sick Children
Division Head
Clinical Biochemistry

Research Institute
Senior Associate Scientist
Molecular Medicine

University of Toronto
Professor
Departments of Biochemistry and Laboratory Medicine & Pathology


Phone: 416-813-8682
Fax: 416-813-6257
Email: khosrow.adeli@sickkids.ca

For more information, visit: Adeli Lab and www.caliperproject.ca

Research Interests

  • Paediatric laboratory medicine and clinical biochemistry
  • Paediatric reference intervals for laboratory biomarkers of health and disease
  • Pathophysiology and molecular mechanisms of diabetic lipid disorders/dyslipidemia
  • Neuroendocrine control of lipid and lipoprotein metabolism

Research Activities

Clinical and Translational Research Studies

CALIPER Program – Paediatric Reference Standards for Biomarkers of Health and Disease

Dr. Adeli has been leading a national initiative in collaboration with other paediatric health centres across Canada to establish a comprehensive database of paediatric reference standards for laboratory biomarkers of paediatric disease. The new database will improve the clinical assessment, diagnosis, and monitoring of children and adolescents presenting with various medical concerns. The database has been largely completed and is available on the CALIPER Project website via a web application (www.caliperdatabase.ca) as well as via a mobile application available on the iTunes and Google Play. 

The CALIPER App provides easy access to comprehensive and up-to-date paediatric reference standards for over 170 tests routinely performed in children and adolescents. It was developed for paediatricians, family physicians and other health-care professionals to facilitate interpretation of medical test results and improve the accuracy of medical decision-making in children.

In the CALIPER program, prospective and retrospective studies are also underway to investigate the influence of age, sex, ethnicity, BMI and other factors on biomarker levels in children and adolescents. Furthermore, the impact of obesity and insulin resistance on fasting and postprandial lipid metabolism is being investigated in adolescents with obesity and different degrees of insulin resistance.

Fundamental Research Studies

Neuroendocrine Regulation of Lipid and Lipoprotein Metabolism in Obese and Diabetic States

Insulin resistant states (obesity, metabolic syndrome, and type 2 diabetes) have become a global epidemic in both children and adults and are major risk factors for atherosclerotic cardiovascular disease, largely due to lipid and lipoprotein abnormalities. The key mechanism underlying this metabolic dyslipidemia is hepatic and intestinal overproduction of atherogenic lipoproteins. 

The focus of our basic research program has been to understand the cellular, molecular and physiological regulation of intestinal chylomicron and hepatic liporprotein (VLDL) production in normal and insulin resistant states. Our laboratory was first to demonstrate intestinal chylomicron overproduction in the insulin resistant hamster and the novel role of gut hormones (glucagon-like peptides (GLP)-1 and GLP-2), observations that have now been confirmed in humans. 

Most recently, we have discovered and reported a complex gut-brain axis (via CNS receptors) triggered following fat ingestion to modulate intestinal chylomicron production by GLP-1. Our current studies are focused on determining the neuroendocrine and molecular mechanisms that control dietary fat absorption and lead to chylomicron overproduction and diabetic dyslipidemia in insulin resistant states.

Achievements

Leadership Positions

  • Vice-Chair, Department of Laboratory Medicine & Pathology, University of Toronto (2017 - present)
  • Director, Postdoctoral Training Program in Clinical Chemistry, University of Toronto (2000 - present)
  • Chair, IFCC Communications and Publications Division (2013 - 2018)
  • Chair, IFCC Public Relations Committee (2007 - 2012)
  • Board of Directors, AACC Academy (2015 - 2018)
  • Editor-in-Chief, Critical Reviews in Clinical Laboratory Sciences (2013 - present)
  • Scientific Advisory Board, Internat. Centre in Genetic Engineering and Biotech (2009 - 2018)
  • President, Commission on Accreditation in Clinical Chemistry (2007 - 2010)
  • Editor-in-Chief, Clinical Biochemistry (1999 - 2006)

Research and Service Awards

  • 2019 AACC Academy Outstanding Research Award, American Association of Clinical Chemistry
  • 2018 Hungarian Academy Honorary Award, Hungarian Academy of Laboratory Medicine
  • 2016 Canadian Society Innovation Award in Laboratory Medicine
  • 2015 Pediatric-Maternal-Fetal Division Award, American Association of Clinical Chemistry
  • 2015 Canadian Society Outstanding Education Award
  • 2006 Canadian Society Outstanding Clinical Chemist Award
  • 2004 Canadian Academy of Clinical Biochemistry, Outstanding Contributions to Clinical Biochemistry

Publications

2019

Stukas S, Higgins V, Frndova H, Gill J, Hubara E, Guerguerian AM, Boutis K, Beauchamp M, Farrell C, Babl FE, Delzoppo C, Greenham M, Wilkinson AA, Crichton A, Anderson V, Adeli K, Hutchison J, Wellington C; Characterisation of serum total tau following paediatric traumatic brain injury: a case-control study. Serum Biomarkers and Quality of Life in Children with Traumatic Brain Injury investigators. Lancet Child Adolesc Health. 2019 Jun 20. pii: S2352-4642(19)30194-4. doi: [Epub ahead of print]

Hoffman S, Alvares D, Adeli K. Intestinal lipogenesis: how carbs turn on triglyceride production in the gut. Curr Opin Clin Nutr Metab Care. 2019 Jul;22(4):284-288.

Alvares D, Hoffman S, Stankovic B, Adeli K. Gut peptide and neuroendocrine regulation of hepatic lipid and lipoprotein metabolism in health and disease. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Mar;1864(3):326-334.

Eny KM, Maguire JL, Dai DWH, Lebovic G, Adeli K, Hamilton JK, Hanley AJ, Mamdani M, McCrindle BW, Tremblay MS, Parkin PC, Birken CS. Association of accelerated body mass index gain with repeated measures of blood pressure in early childhood. Int J Obes (Lond). 2019 Jul;43(7):1354-1362.

Bohn MK, Higgins V, Kavsak P, Hoffman B, Adeli K. High-sensitivity Generation 5 Cardiac Troponin T sex- and age-specific 99th percentiles in the CALIPER cohort of healthy children and adolescents. Clin Chem. 2019 Apr;65(4):589-591.

Tahmasebi H, Higgins V, Woroch A, Asgari S, Adeli K. Pediatric reference intervals for clinical chemistry assays on Siemens ADVIA XPT/1800 and Dimension EXL in the CALIPER cohort of healthy children and adolescents. Clin Chim Acta. 2019 Mar;490:88-97.

2018

Adeli K, Higgins V, Trajcevski K, Palmert MR. Important considerations for interpreting biochemical tests in children. BMJ. 2018 May 24;361:k1950.

Parkin PC, Hamid J, Borkhoff CM, Abdullah K, Atenafu EG, Birken CS, Maguire JL, Azad A, Higgins V, Adeli K. Laboratory reference intervals in the assessment of iron status in young children. BMJ Paediatr Open. 2017 Aug 31;1(1):e000074.

Taher J, Baker C, Alvares D, Ijaz L, Hussain M, Adeli K. GLP-2 dysregulates hepatic lipoprotein metabolism, inducing fatty liver and VLDL overproduction in male hamsters and mice. Endocrinology. 2018 Sep 1;159(9):3340-3350.

Xu XR, Wang Y, Adili R, Ju L, Spring CM, Jin JW, Yang H, Neves MAD, Chen P, Yang Y, Lei X, Chen Y, Gallant RC, Xu M, Zhang H, Song J, Ke P, Zhang D, Carrim N, Yu SY, Zhu G, She YM, Cyr T, Fu W, Liu G, Connelly PW, Rand ML, Adeli K, Freedman J, Lee JE, Tso P, Marchese P, Davidson WS, Jackson SP, Zhu C, Ruggeri ZM, Ni H. Apolipoprotein A-IV binds αIIbβ3 integrin and inhibits thrombosis. Nature Commun. 2018 Sep 6;9(1):3608.  

Hoffman S, Adeli K. LDL receptor gene-ablated hamsters: a rodent model of familial hypercholesterolemia with dominant inheritance and diet-induced coronary atherosclerosis. EBioMedicine. 2018 Jan 30. pii: S2352-3964(18)30041-0.

Higgins V, Asgari S, Chan MK, Adeli K. Pediatric reference intervals for calculated LDL cholesterol, non-HDL cholesterol, and remnant cholesterol in the healthy CALIPER cohort. Clin Chim Acta. 2018 Nov;486:129-134.
Tahmasebi H, Trajcevski K, Higgins V, Adeli K. Influence of ethnicity on population reference values for biochemical markers. Crit Rev Clin Lab Sci. 2018 Aug;55(5):359-375.

Higgins V, Truong D, White-Al Habeeb NMA, Fung AWS, Hoffman B, Adeli K. Pediatric reference intervals for 1,25-dihydroxyvitamin D using the DiaSorin LIAISON XL assay in the healthy CALIPER cohort. Clin Chem Lab Med. 2018 May 24;56(6):964-972.

Ozarda Y, Higgins V, Adeli K. Verification of reference intervals in routine clinical laboratories: practical challenges and recommendations. Clin Chem Lab Med. 2018 Dec 19;57(1):30-37.

2017

Adeli K, Higgins V, Trajcevski K, White-Al Habeeb N. The Canadian laboratory initiative on pediatric reference intervals: A CALIPER white paper. Crit Rev Clin Lab Sci. 2017 Sep;54(6):358-413.

Zhang J, Zamani M, Thiele C, Taher J, Amir Alipour M, Yao Z, Adeli K. AUP1 (Ancient Ubiquitous Protein 1) Is a key determinant of hepatic very-low-density lipoprotein assembly and secretion. Arterioscler Thromb Vasc Biol. 2017Apr;37(4):633-642.

Cagman Z, Bingol Ozakpinar O, Cirakli Z, Gedikbasi A, Ay P, Colantonio D, Uras AR, Adeli K, Uras F. Reference intervals for growth arrest-specific 6 protein in adults. Scand J Clin Lab Invest. 2017 Apr;77(2):109-114.

Taher J, Farr S, Adeli K. Central nervous system regulation of hepatic lipid and lipoprotein metabolism. Curr Opin Lipidol. 2017 Feb;28(1):32-38.

Adeli K, Higgins V, Seccombe D, Collier CP, Balion CM, Cembrowski G, Venner AA, Shaw J; CSCC Reference Interval Harmonization (hRI) Working Group. National survey of adult and pediatric reference intervals in clinical laboratories across Canada: a report of the CSCC Working Group on reference interval harmonization. Clin Biochem. 2017 Nov;50(16-17):925-935.

Panteghini M, Adeli K, Ceriotti F, Sandberg S, Horvath AR. American liver guidelines and cutoffs for "normal" ALT: a potential for overdiagnosis. Clin Chem. 2017 Jul;63(7):1196-1198.

Adeli K. Laboratory medicine - A hidden treasure in healthcare. Clin Biochem. 2017 Aug;50(12):645-647.
Anderson LN, Maguire JL, Lebovic G, Hanley AJ, Hamilton J, Adeli K, McCrindle BW, Borkhoff CM, Parkin PC, Birken CS; Applied Research Group for Kids! (TARGet Kids!) Collaboration. Duration of fasting, serum lipids, and metabolic profile in early childhood. J Pediatr. 2017 Jan;180:47-52.e1.

A full list of publications is available on PubMed