Mohamed Abdelhaleem, MD, PhD, FRCP(C)
The Hospital for Sick Children
Director of Molecular Haematopathology
University of Toronto
Paediatric Laboratory Medicine
Medical degree obtained in Egypt (1986). Research training completed at the University of Manitoba leading to MSc (1990) and PhD (1994) degrees. Clinical training completed in Haematological Pathology at the University of Alberta (1994-1997) leading to FRCPC. Assistant professor at the Department of Pathology, Dalhousie University and haematopathologist and director of Flow Cytometry, QEII Health Sciences Center, Halifax (1997-1999).
Joined the University of Toronto and The Hospital for Sick Children in 1999 as director of Molecular Haematopathology, Department of Paediatric Laboratory Medicine (DPLM). Currently, the head of the Division of Haematopathology at DPLM.
Areas of Specialty
Dr. Mohamed Abdelhaleem is a Haematopathologist and Director of Molecular Haematopathology in DPLM. He is interested in integrating all aspects of the diagnosis of paediatric leukemias, including morphology, special stains, flowcytometry, and molecular testing. Dr. Abdelhaleem also has a research background and current work in his laboratory is focused on two areas, pathways of cell death and the molecular basis of leukemia. Currently, cell death occupies a central position in biomedical research as advances in this field could improve our understanding of how cancer arises and how anti-cancer agents work. Through the use of lymphocyte-mediated and chemotherapy-induced cell death as models, the laboratory is trying to characterize the role of a new class of helicases in cell death. In addition, molecular techniques are being used to elucidate the role played by these molecules in leukemia.
Clinical Care Activities
Diagnosis of haematological disorders
- Cell Death
- RNA helicases
The laboratory is interested in cell death pathways of leukaemia and the role of RNA helicases in cancer.
Future Research Interests
Elucidation of the role of DDX32 in normal and malignant haematopoiesis
Abdelhaleem, M., Maltais L and Wain H. The human DDX and DHX families of putative RNA helicases. Genomics 81:618-622, 2003
Abdelhaleem M. The Actinomycin D-Induced Apoptosis in BCR-ABL-positive K562 Cells is Associated with Cytoplasmic Translocation and Cleavage of RNA Helicase A. Anticancer Research 23:485-490, 2003
Abdelhaleem M. A role for the subcellular localization of Bax in differentiation-induced resistance to apoptosis in HL-60 Cells. Anticancer Research 22:177-182, 2002.
Abdelhaleem M. The novel helicase homologue DDX32 is down-regulated in acute lymphoblastic leukemia. Leukemia Research. 26:945-954, 2002
Abdelhaleem M. Differential Effect of Bcl-xl Over-expression on Cell Death of the Monocytic Leukemia Cell Line U937. Anticancer Research 23: 3911-3916, 2002