About Sickkids
About SickKids

Eric Bouffet, MD

The Hospital for Sick Children
Director, Brain Tumour Program


Research Institute
Senior Associate Scientist
Child Health Evaluative Sciences

University of Toronto

Phone: 416-813-7457
Fax: 416-813-8024
e-mail: eric.bouffet@sickkids.ca

Brief Biography

Dr. Eric Bouffet is Professor of Paediatrics in the University of Toronto and Head of the Neuro-oncology Section in the Division of Haematology/Oncology at The Hospital for Sick Children, Toronto. Dr. Bouffet graduated in 1980 from the medical school at the University of Lyon. Following graduation Dr. Bouffet trained and practiced in Lyon; he was Head of the Department of Neuro-oncology, Centre Leon Berard, during the period 1992-1995. Dr. Bouffet then moved to the United Kingdom where he was Consultant Paediatric Oncologist at the Hospital for Sick Children, Bristol (1996-1998) and the Royal Marsden Hospital, Sutton UK (1998-2000). In 2000 Dr. Bouffet was recruited to The Hospital for Sick Children in Toronto to develop and Head a multidisciplinary paediatric Neuro-oncology Program within the Division of Haematology/Oncology. In 1998-2001 Dr. Bouffet was Chairman of the Brain Tumour Committee of the International Society of Pediatric Oncology (SIOP). Dr. Bouffet is a Senior Associate Scientist in the Research Institute at The Hospital for Sick Children. His research interests are in the area of novel treatments and clinical trials in children with brain tumours. Dr. Bouffet is author of over 150 peer-reviewed manuscripts and author/co-author on numerous book chapters in the field of neurooncology. Dr. Bouffet was the recipient of the Division's Alvin Zipursky Teaching Award in 2002.

Research Interests

  • Phase II studies in paediatric brain tumours
  • E-health (relaying health care information via the Internet)
  • Organization of complex care
  • Cognitive development and brain irradiation

Research Activities

Phase II studies in paediatric brain tumours
I co-ordinate a multicentric Phase II study on Single Agent Vinblastine for recurrent/refractory low-grade glioma. I also co-chair the North American study for paediatric intracranial non-germinomatous germ cell tumours and co-chair the European SIOP (International Society of Paediatric Oncology) ependymoma study.

I am currently involved in several ongoing studies. These include: rating paediatric brain web sites by physicians and non physicians, creating appropriate medical information for an E-Health format and developing a paediatric brain tumour Web site in partnership with The Hospital for Sick Children.

Organization of Complex Care
I am involved in the co-ordination of care for children with complex needs. We are currently in the pre-phase of a study aiming to improve the co-ordination of care for the brain tumour population at The Hospital for Sick Children.

Interventional Programs
I am also interested in the development of interventional educational programs for children with brain tumours. The objective is to develop specific learning programs and learning tools for children with brain tumours. The leader of this area of research is Dr. Mabbott, a psychologist in the Brain Tumour Program.


Lafay-Cousin L, Holm S, Qaddoumi I, Nicolin G, Bartels U, Tabori U, Huang A, Bouffet E. Weekly vinblastine in pediatric low-grade glioma patients with carboplatin allergic reaction. Cancer. 2005 Jun 15;103(12):2636-42

Mabbott DJ, Spiegler BJ, Greenberg ML, Rutka JT, Hyder DJ, Bouffet E. Serial evaluation of academic and behavioral outcome after treatment with cranial radiation in childhood. J Clin Oncol. 2005 Apr 1;23(10):2256-63

Tabori U, Sung L, Hukin J, Laperriere N, Crooks B, Carret AS, Silva M, Odame I, Mpofu C, Strother D, Wilson B, Samson Y, Bouffet E. Canadian Pediatric Brain Tumor Consortium. Medulloblastoma in the second decade of life: a specific group with respect to toxicity and management: a Canadian Pediatric Brain Tumor Consortium Study.
Cancer. 2005 May 1;103(9):1874-80

Spiegler BJ, Bouffet E, Greenberg ML, Rutka JT, Mabbott DJ. Change in neurocognitive functioning after treatment with cranial radiation in childhood. J Clin Oncol. 2004 Feb 15;22(4):706-13

Capra M, Hargrave D, Bartels U, Hyder D, Huang A, Bouffet E. Central nervous system tumours in adolescents. Eur J Cancer. 2003 Dec;39(18):2643-50