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About Sickkids
About SickKids

Allan Coates, MD

Research Institute
Emeritus Scientist
Translational Medicine

University of Toronto
Professor
Paediatrics


Phone: 416-813-6215
Fax: 416-813-6246
Email: allan.coates@sickkids.ca

Research Interests

The bulk of my research is aimed at adapting new technologies in the aerosol field to patient care. In the past, our work has led to a change to more efficient nebulizer systems for the treatment of cystic fibrosis (CF) throughout the country and our current research will look at adapting the latest technologies in order to shorten treatment time and, hopefully, improve adherence to recommended therapy by reducing time commitments necessary.

Other aerosol work has involved lung gene delivery systems for use in larger animals and the characterization of the technical specification necessary for large scale measles immunization by the World Health Organization. We continue to have ongoing collaborative work with colleagues in the SickKids Emergency Department and we are currently working with colleagues at the University of Tours, France to develop an aerosol vaccine formulation protective against human papilloma virus, the cause of cervical cancer. We also have an ongoing interest with the role of exercise and exercise testing in cystic fibrosis.

Publications

Scolnik D, Coates AL, Stephens D, Da Silva Z, Lavine E, Schuh S. A randomized trial of controlled delivery of high versus low humidity verus mist therapy in croup. JAMA 295: 1274-1280, 2006.

Coates AL, Tipples G, Leung K, Gray M, Louca E. How many infective viral particles are necessary for successful mass measles immunization by aerosol? Vaccine 24: 1578-1585, 2006.

Schneiderman-Walker J, Wilkes DL, Strug L, Lands LC, Pollock SL, Selvadurai HC, Hay J, Coates AL, Corey M. Sex differences in habitual physical activity and lung function decline in children with cystic fibrosis. J Pediatr 147: 321-326, 2005.

Leung K, Louca E, Grey M, Tipples G, Coates AL. Use of the next generation pharmaceutical impactor for particle size distribution measurements of live viral aerosols vaccines. J Aerosol Med 18: 414-426, 2005.

Koehler DR, Frndova H, Leung K, Louca E, Palmer D, Ng P, McKrlie C, Cox P, Coates AL, Hu J. Aerosol delivery of an enhanced helper-dependent adenovirus formulation to rabbit lung using an intratracheal catheter. J Gene Med 7: 1409-1420, 2005.

Leung K, Louca E, Coates AL. Comparison of breath enhanced to breath actuated nebulizers for rate, consistency, and efficiency. Chest 26: 1619-1627, 2004.