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About Sickkids
About SickKids

Christopher Caldarone, MD, FRCSC

The Hospital for Sick Children
Department of Surgery

Staff Cardiovascular Surgeon
Cardiovascular Surgery

Perioperative Services

Research Institute
Senior Associate Scientist
Translational Medicine

Phone: 416-813-7794
Fax: 416-813-7369
Email: christopher.caldarone@sickkids.ca
Alternate Contact: Elizabeth Kim
Alternate Phone: 416-813-5102
Alternate Email: ikyoung-elizabeth.kim@sickkids.ca

Research Interests

Pulmonary Vein Stenosis

Pulmonary Vein Stenosis is a major unsolved problem in congenital heart disease. When limited to the junction of the pulmonary veins in the left atrium, surgical therapy is often successful. Unfortunately, pulmonary vein vasculopathy often extends upstream into the lung parenchyma with a very high mortality rate. We are examining pelagic mechanisms of upstream pulmonary vein stenosis using cell-based, mouse and porcine models.

Cardiovascular Data Management Centre

The Cardiovascular Data Management Centre (CVDMC) collects clinical data from patients with cardiovascular disease across the entire University of Toronto. The data is aggregated in a linkage-rich environment which fosters quality improvement initiatives and clinical research.


  • 2016 – Robert B. Salter Chair of Surgical Research
  • 2009-16 – Chair, Division of Cardiac Surgery, University of Toronto
  • 2015 – Surgeon-in-Chief, Department of Surgery
  • 2013 – Associate Editor, Journal of Thoracic and Cardiovascular Surgery
  • 2009 – Chair, Division of Cardiac Surgery, University of Toronto
  • 2007 – Editorial Board, Journal of Thoracic and Cardiovascular Surgery


1. Lo Rito M, Osman O. Al Radi, Saedi A, Kotani Y, Svarajan V, Russell J, Caldarone CA, Van Arsdell GS, Honjo O. (2017). Chylothorax and Pleural Effusion in Contemporary Extracardiac Fenestrated Fontan Completion. The Journal of Thoracic and Cardiovascular Surgery.
2. Hickey E, Pham-Hung E, Nosikova Y, Halvorsen F, Gritti M, Schwartz S, Caldarone CA, Van Arsdell GS, (2017).  NASA Model of "Threat and Error" in Pediatric Cardiac Surgery: Patterns of Error Chains. The Annals of Thoracic Surgery. 103(4): 1300-1307.
3. Nield LE, Dragulescu A, MacColl C, Manlhiot C, Brun H, McCrindle BW, Kuipers B, Caldarone CA, Miner SE, Mertens L. (2017). Coronary artery Doppler patterns are associated with clinical outcomes post-arterial switch operation for transposition of the great arteries. European heart journal cardiovascular Imaging.
4. Wilder TJ, McCrindle BW, Hickey EJ, Ziemer G, Tchervenkov CI, Jacobs ML, Gruber PJ, Blackstone EH, Williams WG, DeCampli WM, Caldarone CA, Pizarro C, Congenital Heart Surgeons' Society. (2017). Is a hybrid strategy a lower-risk alternative to stage 1 Norwood operation?. The Journal of Thoracic and Cardiovascular Surgery. 153(1): 163-172.e6.
5. Mahgoub L, Kaddoura T, Kameny AR, Lopez Ortego P, Vanderlaan RD, Kakadekar A, Dicke F, Rebeyka I, Calderone CA, Redington A, Del Cerro MJ, Fineman J, Adatia I. (2017). Pulmonary vein stenosis of ex-premature infants with pulmonary hypertension and bronchopulmonary dysplasia, epidemiology, and survival from a multicenter cohort. Pediatric Pulmonology. 52(8): 1063-1070.