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Campos Lab site

Brief Biography

• Post-doctoral Fellowship, Howard Hughes Medical Institute, New York University School of Medicine (in Danny Reinberg’s laboratory)
• PhD, the Experimental Medicine program, University of British Columbia
• B.Sc., University of Ottawa

Research Interests

• Epigenetics & Chromatin Biology
• Histones & Histone Chaperones
• Cell Division & Carcinogenesis

Research Activities

Dr. Eric Campos' laboratory focuses on the mechanisms of epigenetic inheritance: self-perpetuating changes on chromatin that influence gene expression independently of DNA sequence.

Histones play a critical structural role by organizing and packaging DNA.  Our genome encodes numerous histones variants, all of which are subject to a large number of posttranslational modifications.  These variants, and modifications, help dictate which proteins bind local chromatin structures and therefore carry tremendous influence on the expression of underlying genes.  This information can be transmitted through numerous cell cycles, and is believed to be epigenetic.

While histones carry important information, they are also routinely displaced and modified as DNA is replicated, transcribed, and repaired.  Dr. Campos and his team aim to understand the spatiotemporal regulation of epigenetic factors that cells utilize to maintain a transcriptional ‘memory’ through cell division.  Emphasis is not only placed on the biochemical characterization of histones, histone chaperones and the protein complexes that help perpetuate epigenetic information under normal circumstances, but also on how the process goes awry in a number of childhood cancers.

Publications

Full publication list is available through PubMed.

Selected Publications

Campos EI, Smits AH, Kang YH, Landry S, Escobar TM, Nayak S, Ueberheide BM, Durocher D, Vermeulen M, Hurwitz J, Reinberg D. (2015) Analysis of the Histone H3.1 Interactome: A Suitable Chaperone for the Right Event. Mol Cell. 60(4):697-709. PMID: 26527279

Campos EI, Stafford JM, Reinberg D. (2014) Epigenetic inheritance: histone bookmarks across generations. Trends Cell Biol. 24(11):664-74. PMID: 25242115

Kanno T, Kanno Y, LeRoy G, Campos E, Sun HW, Brooks SR, Vahedi G, Heightman TD, Garcia BA, Reinberg D, Siebenlist U, O'Shea JJ, Ozato K. (2014) BRD4 assists elongation of both coding and enhancer RNAs by interacting with acetylated histones. Nat Struct Mol Biol. 21(12):1047-57. PMID: 25383670.

Campos EI, Fillingham J, Li G, Zheng H, Voigt P, Kuo WH, Seepany H, Gao Z, Day LA, Greenblatt JF, Reinberg D. (2010) The program for processing newly synthesized histones H3.1 and H4. Nat Struct Mol Biol. 17(11):1343-51.
PMID: 20953179

Campos EI, Reinberg D. (2010) New chaps in the histone chaperone arena. Genes Dev. 24(13):1334-8. PMID: 20595228

Campos EI, Reinberg D. (2009) Histones: annotating chromatin. Annu Rev Genet. 43:559-99. PMID: 19886812