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About Sickkids
About SickKids

Flavio Coceani, MD

Research Institute
Adjunct Scientist
Translational Medicine

University of Toronto
Paediatrics
Professor Adjunct


Email: coceani@sssup.it

Research Interests

Through the years, a distinct line in Dr. Coceani's research has focused on perinatal physiology and medicine, with specific interest on vascular shunts (i.e., ductus arteriosus and ductus venosus) and the pulmonary circulation. The approach constantly had a translational underpinning, with a special reward deriving from the study of vasoregulatory mechanisms in the ductus arteriosus. This research has led to the use of prostaglandin as a life-saving tool for neonates with congenital heart malformations and, more generally, to the pharmacological manipulation of the duct for therapeutic purposes.

Current interests deal with myocardial cell manipulation as adjuvant to antenatal corrective cardiac surgery. Collaborative work is also in progress with colleagues at SickKids on the role of the ductus venosus in the compensatory adjustments to intrauterine growth restriction and hypoxic insult.

Publications

Coe Y, Haleen SJ, Welch KM, Liu Y-A, Coceani F. The ETA receptor antagonists, PD 156707 (CI-1020) and PD 180988 (CI-1034), reverse the hypoxic pulmonary vasoconstriction in the perinatal lamb. J Pharmacol Exp Ther 302: 672-680, 2002.

Adeagbo ASO, Kelsey L, Coceani F. Endothelin-induced constriction of the ductus venosus in fetal sheep: developmental aspects and possible interaction with vasodilatory prostaglandin. Br J Pharmacol 142: 727-736, 2004.

Baragatti B, Brizzi F, Barogi S, Laubach VE, Sodini D, Shesely EG, Regan RF, Coceani F. Interactions between NO, CO and an endothelium-derived hyperpolarizing factor (EDHF) in maintaining patency of the ductus arteriosus in the mouse. Br J Pharmacol 151: 54-62, 2007.

Baragatti B, Laniado-Schwartzman M, Angeloni D, Scebba F, Ciofini E, Sodini D, Ottaviano V, Nencioni S, Paolicchi A, Graves JP, Zeldin DC, Gotlinger KH, Luin S, Coceani F. EDHF function in the ductus arteriosus: evidence against involvement of epoxyeicosatrienoic acids and 12S-hydroxyeicosatetraenoic acid. Am J Physiol Heart Circ Physiol 297: H2161-H2168, 2009.

Baragatti B, Ciofini E, Scebba F, Angeloni D, Sodini D, Luin S, Ratto GM, Ottaviano V, Pagni E, Paolicchi A, Nencioni S, Coceani F. Cytochrome P450 3A13 and endothelin jointly mediate ductus arteriosus constriction to oxygen in mice. Am J Physiol Heart Circ Physiol 300: H892-H901, 2011.

Baragatti B, Ciofini E, Sodini D, Luin S, Scebba F, Coceani F. Hydrogen sulfide in the mouse ductus arteriosus: a naturally occurring relaxant with potential EDHF function. Am J Physiol Heart Circ Physiol 304: H927-H934, 2013.