John Coles, MD, FRCSC
The Hospital for Sick Children
Cardiac Biobank, SAB
Labatt Family Heart Centre
Senior Associate Scientist
University of Toronto
Department of Surgery
Hospital Tissue Bank
Phone: 416-813-6204, ext. 206204
Dr. John Coles received his medical degree from the University of Western Ontario, and his FRCSC in Cardiovascular and Thoracic Surgery in 1982. He has had internships and residencies in Vancouver, London, and Toronto. Dr. Coles joined the SickKids team in 1984 as a consulting staff surgeon, taking on a position in the Research Institute in 1990. He also works in the academic community as a professor in the Department of Surgery at the University of Toronto.
The research environment is very supportive of the clinical aspects of The Hospital for Sick Children, which is why Dr. Coles enjoys working here. As both a researcher and a surgeon, he is a witness to how research can influence clinical care.
Our research studies are directed towards understanding the molecular biology of hypertrophy which occurs in congenital heart disease. We are specifically focused on signaling cascades which promote beneficial compensatory cardiac hypertrophy. Our lab is also focused on the characterization of cardiac-progenitor cells resident within the heart in congenital heart disease. Both areas of study involve mouse models of cardiac hypertrophy and parallel analysis of clinical samples exhibiting various degrees and types of hypertrophy.
Hannigan GE, Coles JG, Dedhar S. Integrin-linked kinase at the heart of cardiac contractility, repair and disease. Circ Res 2007;100(10):1408-14.
Arab S, Konstantinov IE, Boscarino C, Cukerman E, Mori A, Li J, Liu PP, Redington AN, Coles JG. Early gene expression profiles during intraoperative myocardial ischemia-reperfusion in cardiac surgery. J Thorac Cardiovasc Surg 2007;134:74-81.
Lu H, Dai X, Du C, Zhou Y, Lau A, Yamabi H, Li R-K, Hinek A, Takahashi M, Husain M, Hannigan GE, Coles JG. Integrin-Linked Kinase (ILK) is upregulated in cardiac hypertrophy and causes hypertrophy in transgenic mice. Circulation 2006;114(21):2271-2279.
Yamabi H, Lu H, Dai X, Lu Y, Hannigan G, Coles JG. Overexpression of integrin-linked kinase induces cardiac stem cell expansion. J Thorac Cardiovasc Surg 2006;132(6):1272-9.
Coles JG, Boscarino C, Takahashi M, Grant D, Chang A, Ritter J, Dai X, Du C, Musso G, Yamabi H, Goncalves J, Kumar AS, Woodgett J, Lu H, Hannigan G. Cardioprotective stress response in the human fetal heart. J Thorac Cardiovasc Surg 2005;129:1128-36.