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About Sickkids
About SickKids

Manuel Carcao, MD

The Hospital for Sick Children

Medical Director, Hemostasis Program

Research Institute
Senior Associate Scientist
Child Health Evaluative Sciences

University of Toronto

Phone: 416-813-5367
Fax: 416-813-5327
Alternate Contact: Eleanor Paulino
Alternate Phone: 416-813-7654 ext. 205886
Alternate Email: eleanor.paulino@sickkids.ca

Brief Biography

Dr. Carcao is a Clinician Investigator in the Division of Haematology/Oncology (Department of Paediatrics), Senior Associate Scientist in the Child Health Evaluative Sciences program at SickKids and Professor of Paediatrics at the University of Toronto. He is also a member of the Hemostasis program in Haematology.

Dr. Carcao received his medical degree in 1990 and a Masters of Science degree in Clinical Epidemiology in 2007 from the University of Toronto. He joined the division as a faculty member in 1999 following completion of haematology/oncology and hemostasis fellowships (1995-1999). 

Dr Carcao has served in many organizational and administrative capacities in the field of bleeding disorders. These include:

  • President; Association of Hemophilia Clinic Directors of Canada (AHCDC; 2006 to 2008)
  • Chair; Inhibitor Subcommittee of the AHCDC (2002-06; 2013-2017)
  • Chair; Canadian Paediatric Thrombosis and Haemostasis Network (2016-2018)
  • Chair; Canadian Haemophilia Society Peer Review Committee (2016-present)
  • Chair; INPH (International Network of Paediatric Hemophilia). (2017-present)
  • Co-Chair; FVIII, FIX and Rare Inherited Bleeding Disorders Subcommittee of the ISTH

    He is on the editorial board of several well-known journals. He has been an invited lecturer on many occasions, and is the author of over 132 peer-reviewed papers and textbook chapters.

Research Interests

  • Prevention of bleeding in haemophilia
  • Inhibitor development in haemophilia
  • Immune thrombocytopenia purpura
  • Clinical trials
  • Hereditary Spherocytosis and other red cell membrane disorders
  • Medical management of vascular tumors and malformations

Research Activities

Dr. Carcao’s research interests are in the study of congenital bleeding disorders (haemophilia, Von Willebrand disease and rare inherited coagulation and platelet disorders) and in particular the study of inter-patient disease variability with respect to inhibitor development, prophylaxis needs and pharmacokinetics. Dr. Carcao also has a substantial clinical and research interest in childhood immune thrombocytopenia, hereditary spherocytosis and the medical management of vascular tumours and malformations.


Pelland-Marcotte MC, Humpl T, James P, Rand M, Bouskill V, Reyes JT, Bowman ML, Carcao M. Acquired von Willebrand syndrome-a complication of idiopathic pulmonary hypertension. Br J Haematol 2018 Aug 23. [Epub ahead of print] (C/R)

Duan L, *Renzi S, Weidman D, Waespe N, Chami R, Manson D, Cada M, Carcao MD. Sirolimus treatment of an infant with intrathoracic Kaposiform Hemangioendothelioma complicated by life-threatening pleural and pericardial effusions. J Pediatr Hematol Oncol 2018 Jul 23. [Epub ahead of print] (C)

Beck CE, Carcao M, Cada M, Porter S, Blanchette VS, Parkin PC. A quality improvement bundle to improve informed choice for children with typical, newly diagnosed immune thrombocytopenia. J Pediatr Hematol Oncol 2018 Jul 19. [Epub ahead of print] (C/R)

Carcao M, Lambert T, Leissinger C, Escuriola-Ettingshausen C, Santagostino E, Aledort L on behalf of the International Prophylaxis Study Group (IPSG) Prophylaxis re-visited: the potential impact of novel factor and non-factor therapies on prophylaxis. Haemophilia 2018 Jul 10. [Epub ahead of print]

Pugi J, Carcao M; Drury LJ, Langer J. Results After Laparoscopic Partial Splenectomy for Children with Hereditary Spherocytosis: Are Outcomes Influenced by Genetic Mutation? J Pediatr Surg 2018 May; 53(5):973-975 (R)

Al-Battat S, Rand ML, Bouskill V, Lau W, Blanchette VS, Kahr WHA, Rivard GE, Carcao M. Glanzmannthrombasthenia platelets compete with transfused platelets reducing the haemostatic impact of transfused platelets. Br J Haematol 2018 May; 181(3):410-413 (C/R)

Carcao M, Shapiro, A, Staber J, Hwang N, Druzgal C, Lieuw K, Belletrutti M, Thornburg C, Ahuja S, Morales-Arias J, Dumont J, Miyasato G, Tsao E, Jain, N, Pipe S. rFVIIIFc for immune tolerance induction in patients with severe haemophilia A with inhibitors – a retrospective analysis. Haemophilia 2018 Mar; 24(2):245-252  (R)

Carcao M, Altisent C, Castaman G, Fukutake K, Kerlin B, Kessler C, Lassila R, Nugent D, Oldenburg J, Garly ML, Rosholm A, and Inbal A. Long-term evaluation of recombinant FXIII (rFXIII-A2) prophylaxis in preventing bleeds and permitting surgery in patients with congenital factor XIII A-subunit deficiency. Thromb Haemost 2018 Mar; 118(3):451-460. (R)

Carcao M, Avila L, Leissinger C, Blanchette V, Aledort L on behalf of the Factor Utilization Expert Working Group of the International Prophylaxis Study Group (IPSG) and participating Survey Investigators. An International Prophylaxis Study Group (IPSG) survey of prophylaxis in inhibitor positive children/adults with severe haemophilia. Haemophilia 2017 Sep; 23(5):e444-e447 (R)

Carcao M, Avila L, Leissinger C, Blanchette V, Aledort L on behalf of the Factor Utilization Expert Working Group of the International Prophylaxis Study Group (IPSG) and participating Survey Investigators. An International Prophylaxis Study Group (IPSG) survey of prophylaxis in adults with severe haemophilia. Haemophilia 2017 Sep; 23(5):e447-e450 (R)

Carcao M, Kearney S, Santagostino E, Oyesiku JO, Young NL, Meunier J, Hoxer CS, Zhang C, Blanchette VS. Insight in health-related quality of life of young children with haemophilia B treated with a long-acting nonacog beta pegol recombinant factor IX. Haemophilia 2017 May; 23(3):e222-e224 Mar 30.

Labarque V, Perinparajah V, Bouskill V, Stain AM, Wakefield C, Manuel M, Blanchette VS, Carcao MD.Factor VIII and Von Willebrand factor levels in 277 unselected carriers of hemophilia A. Am J Hematol 2017 Jun; 92(6):E94-E96.

Sholzberg  M, Floros G, Schneiderman JE, Kahr W, Rand ML, Pluthero F, Hossain T, Mahamad S, Nisenbaum, R, Zhang, C, Whitney, K, O’Neill, NE Teitel J, Carcao M. Effect of Moderate Intensity Exercise on Hemostatic Capacity in Adults with Hemophilia A and B: Pilot Study. Haemophilia 2017 Mar; 23(2): e162-165.

Carcao M, Fukutake K, Inbal A, Kerlin B, Lassila R, Oldenburg J, Garly M-L, Nugent D. Developing the first recombinant Factor XIII for congenital Factor XIII deficiency: clinical challenges and successes.Seminars in Thrombosis and Haemostasis 2017 Feb;43(1):59-68.