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About Sickkids
About SickKids

Mary Corey, PhD

The Hospital for Sick Children
Gastroenterology, Hepatology and Nutrition

Research Institute
Senior Scientist Emeritus
Child Health Evaluative Sciences

University of Toronto
Public Health Sciences


Phone: 416-813-5750
Fax: 416-813-5292
Email: mary.corey@sickkids.ca

Brief Biography

Mary Corey is a Senior Scientist in the Hospital for Sick Children Research Institute and Professor at the University of Toronto in Departments of Public Health Sciences, Paediatrics, and Health Policy, Management and Evaluation. Dr. Corey created the comprehensive Toronto CF database, which is central to a multi-disciplinary approach to CF that has been praised as a model of bench-to-bedside research. Her research has focussed on statistical models to explain the extreme variability of disease in CF, and the complex interactions between multiple genetic and environmental factors that cause disease in general. She has served as consultant to national CF data registries in Canada and several other countries. Dr. Corey is a founding member of the Genetic Statistics Group at the University of Toronto which has been awarded a National Centers of Excellence award for developing new statistical methods for human genetics research (1999-present). Dr. Corey's research is also funded by the Canadian Cystic Fibrosis Foundation (1977-present), the US National Institutes of Health (1989-present), and Genome Canada (2002-present).

Research Interests

  • Epidemiology of cystic fibrosis
  • Genetic epidemiology of complex traits

Research Activities

Although cystic fibrosis (CF) is a classic genetic disease, the severity and progression of symptoms are extremely variable.

My research is focused on explaining this variability in the regional Toronto CF Database and the Canadian CF Patient Data Registry. Survival analysis shows the relative risks associated with many factors like sex, mode of diagnosis, pancreatic function, lung function, and infection. Longitudinal regression analysis defines the rate of decline in lung function and its relationship to other factors, including CF mutation categories, as well as other genes that may modify CF severity.

These studies produce the knowledge necessary to develop and assess new treatments for CF, and provide a model for studying other complex genetic diseases.


Speert DP, Henry D, Vandamme P, Corey M, Mahenthiralingam E. Epidemiology of Burkholderia cepacia in patients with cystic fibrosis, Canada. Emerg Infect Dis 2002;8:181-7, 2002.

Ip WF, Dupuis A, Ellis L, Beharry S, Morrison J, Stormon M, Corey M, Rommens JM, Durie PR. Serum pancreatic enzymes define the pancreatic phenotype in patients with Shwachman Diamond syndrome. J Pediatr;141:259-65, 2002.

Beharry S, Ellis L, Corey M, Marcon M, Durie P. How useful is fecal pancreatic elastase 1 as a marker of exocrine pancreatic disease? Evaluation of patients with a variety of intestinal and pancreatic disorders. J Pediatr;141:84-90, 2002.

Schuh S, Coates A, Binnie R, Allin T, Goia C, Corey M, Dick PT. Efficacy of oral dexamethasone in outpatients with acute bronchiolitis. J Pediatr;140:27-32, 2002.

Sajjan U, Corey M, Humar A, Tullis E, Cutz E, Ackerley C, Forstner J. Immunolocalization of B. cepacia in the lungs of cystic fibrosis patients. J Med Microbiol;50:535-46, 2001.

Wilson DC, Rashid M, Durie PR, Tsang A, Kalnins D, Andrew M, Corey M, Shin J, Tullis E, Pencharz PB. Treatment of vitamin K deficiency in cystic fibrosis: effectiveness of a daily fat-soluble vitamin combination. J Pediatr;138:851-5, 2001.

Schuh S, Reisman J, Aleshehri M, Dupuis A, Corey M, Arseneault R, Alothman G, Tennis O, Canny G. A comparison of inhaled fluticasone and oral prednisone for children with severe acute asthma. N Engl J Med.;343:689-94, 2000.

Gilljam M, Antoniou M, Shin J, Dupuis A, Corey M, Tullis E. Pregnancy in cystic fibrosis: fetal and maternal outcome. Chest.;118:85-91, 2000.

Ginzberg H, Shin J, Ellis L, Goobie S, Morrison J, Corey M, Durie PR, Rommens JM. Segregation analysis in Shwachman-Diamond syndrome: evidence for recessive inheritance. Am J Human Genet;66:1413-1416, 2000.

Schneiderman-Walker J, Pollock SL, Corey M, Wilkes DD, Canny GJ, Pedder L, Reisman JJ. A randomized controlled trial of a three year home exercise program in cystic fibrosis. J Pediatrics;136:304-10, 2000.