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About Sickkids
About SickKids

Miguel Cortez, MD, CSCN(C)

The Hospital for Sick Children
Neurophysiologist
Neurology

Research Institute
Project Director
Neurosciences & Mental Health

University of Toronto
Associate Professor
Paediatrics


Phone: 416-813-5668
Fax: 416-813-6334
Email: miguel.cortez@sickkids.ca

Brief Biography

Doctor of Medicine and Surgery (1988) from the Central University of Ecuador, Quito, Ecuador and diplomate of the Canadian Society of Clinical Neurophysiology since 1994.  He is a member of the Canadian Society of Clinical Neurophysiologists, the Eastern Association of Electroencephalographers Inc. since 1994 and the American Epilepsy Society since 1996.  He joined the scientific staff of the Division of Neurology in 1998 and has been actively involved in teaching of clinical and experimental neurophysiology.

Clinical Care Activities 

  • EEG/VEEG of paediatric epileptic syndromes
  • EEG of paediatric encephalopaties

Areas of Specialty 

  • Electroencephalography

Academic Background

Clinical EEG
The Hospital for Sick Children

Research Interests

  • EEG and VEEG characterization of animal models for refractory epileptic syndromes (West, Lennox-Gastaut, Rasmusen, Rett's).
  • Experimental epileptogenesis, sleep modulation of epilepsies
  • Chronophysiology of epilepsies.

Research Activities 

  • EEG and VEEG monitoring of refractory models of epilepsies
  • Atypical absence seizures derived from developmental cholesterol synthesis inhibition.

Future Research Interests 

EEG and VEEG monitoring of animal models derived from genetic mutations.

Achievements

Recognition, Outstanding Effort in Electrophysiology Teaching Neurology Trainees, The Hospital for Sick Children, Dept. of Paediatrics, Annual Report. 1996

William A. Hawke Award for Excellence in Clinical Teaching, Division of Neurology, The Hospital for Sick Children. 2001

William A. Hawke Award for Excellence in Clinical Teaching, Division of Neurology, Hospital for Sick Children. 2003

William A. Hawke Award for Excellence in Clinical Teaching, Division of Neurology, Hospital for Sick Children. 2007

Research Awards:

Atypical Absence Epilepsy: GABA B Receptor-Mediated Mechanisms. Snead OC (PI), Francis J, Cortez MA: Canadian Institutes of Health Research ($315,376 2000 - 2003)

Atypical Absence Epilepsy: GABA(B) Receptor Mediated Mechanisms. Snead OC (PI), Cortez MA, Velazquez JL: Canadian Institutes of Health Research ($726,430 2003 - 2008)

Publications

Cortez MA, Shen L, Wu Y, Aleem IS,Trepanier CH, Sadeghnia HR, Ashraf A, Kanawaty A, Liu CC, Stewart L, Snead OC III:  Infantile spasms and Down syndrome:  A new animal model.  Pediatr Res:  2009:  Jan 28.  DOI # 10.1203/PDR.0b013e31819d9076.

Bercovici E, Cortez MA, Snead OC III: 5-HT2 modulation of AY-9944 induced atypical absence seizures. Neuroscience Letters 2007 Mar 2: doi: 10.1016/j.neulet.2007.02.062.

Stewart LS, Persinger MA, Cortez MA, Snead OC III:  Chronobiometry of behavioral activity in the Ts65Dn model of down syndrome. Behaviour Genetics 2007: 37(2): pp 388-398.

Cortez MA, Perez Velazquez JL, Snead OC III: Animal models of epilepsy and progressive effects of seizures. Advances in Neurology 2006: 97: pp 293-304.

Cortez MA, Snead OC III: Pharmacological models of generalized absence seizures in rodents. In: Chapter 10: Models of Seizures and Epilepsy (Pitkanen A, Schwartzkroin PA, Moshe SL, eds). Elsevier, San Diego, California 2006: pp 111-126

Cortez MA, Wu Y, Gibson KM, Snead OC III: Absence seizures in succinic semialdehyde dehydrogenase deficient mice: A model of juvenile absence epilepsy. Pharmacol Biochem Behav. 2004: 79(3): pp 547-553.

Cortez MA, Cunnane SC, Snead OC III: Brain sterols in the AY-9944 rat model of atypical absence seizures. Epilepsia 2002: 43(1): pp 3-8.

Cortez MA, McKerlie C, Snead OC III. A model of atypical absence seizures: EEG, pharmacology, and developmental characterization. Neurology. 2001 Feb 13; 56(3):341-9.