Brief Biography

Dr. Andrea Doria received her medical degree from the Universidade Federal do Parana, Brazil, and did her training in Paediatrics and Radiology at the Universidade de Sao Paulo, Brazil. She then received a PhD in medical sciences from the Universidade de Sao Paulo, Brazil. She moved to Canada to pursue a fellowship in Paediatric Radiology and obtained a master’s degree in clinical epidemiology at the University of Toronto. During her fellowship she received the 2002 John Caffey Award for her work on BOLD MRI in experimental arthritis and the 2003 John Kirkpatrick Young Investigator Award for her meta-analysis in appendicitis.
Her passion is the investigation of potential imaging markers to track angiogenesis-related factors (cause) and early cartilage degeneration (effect) in arthritis.

Her teaching interests include the development and implementation of a course on “Introduction to Research for Radiologists” with the goal of improving the quality of research in radiology.

Research Interests

• Musculoskeletal imaging
• Ultrasound and MR imaging
• Angiogenesis

Research Activities 

Dr. Doria's main research interests are:

• to test measurement properties (reliability, validity, responsiveness, sensitivity, specificity) of novel MRI and ultrasound techniques for evaluation of musculoskeletal disorders in the paediatric population
• to develop and test scales for measurement of osteoarticular changes in children

Future Research 

Her future research goal is to be able to translate innovative experimental MRI and ultrasound techniques into human clinical research.

External Funding

2007 - Bayer Health Care. Partnership Fund. Functional-molecular MR imaging for physiologic characterization and cartilage damage prediction in a rabbit model of hemophilic arthropathy.

August 31, 2007 - (2 years) Co-investigators: Cheng H-L (Co-Principal Investigator), Miller E, Sussman M, White L, Babyn P, Gahunia P, Peel S, Yeung R, Alman B, Moineddin R, Blanchette V.

2006 - Bayer Health Care. Research Agreement. Measurement properties of ultrasound for assessment of hemophilic arthropathy. MRI correlation.

December 18, 2006 – (1 year) Co-investigators: Srivastava A, Gibikote S, Keshava S.N, Poonnoose P, Blanchette V, Babyn P, Moineddin R, Hilliard P.

2006 - Radiological Society of North America - Grant No. SD0603 Functional MR imaging for early detection and physiologic characterization of inflammatory arthritis in a rabbit model.

July 1, 2006 - (1 year) Co-investigators: Belik J, Kassner A, Cheng H.L, Crawley A, Yeung R, Tomlinson G.

2006 - New Investigator Grant – SickKids Foundation - Grant No. XG 06-050 Predictors for diagnostically accurate ultrasound in children with suspected appendicitis.

March 28, 2006 - (2 years) Co-investigators: Schuh S (Co-Principal Investigator), Langer J, Cheng A, Tomlinson G.

2003 - The Hospital for Sick Children Seed Grant Competition for Patient-Based Research Contrast-enhanced triggered harmonic sonography for quantification of synovial blood flow in an antigen-induced arthritis model (Number of successful applicants: 32% - 10 out of 31.

March 25, 2003 (2 years) Investigators: Babyn P., Doria A.S., Dick P., Burns P., Pritzker K.

Achievements

2006 - Canadian Child Health Clinician-Scientist Program – Career Development Award.
Canadian Institutes of Health Research, Sick Kids Foundation and British Columbia Children’s Hospital Foundation.
July 1, 2006 – 4 year period

2005 – Seed Grant Funding – Department of Medical Imaging - University of Toronto
Title: Paediatric Musculoskeletal Imaging
Jan 21, 2005 - 3 year period

2004 – Chair’s Start-up Fund.
Title: Functional MR imaging assessment of therapeutic outcomes in experimental arthritis. Date: October 13, 2004. Toronto – ON – Canada

2004 – Medical Imaging Research and Development Award.
Title: Comparative measurements of BOLD signal in experimental arthritis according to variations in the region-of-interest.
Date: July 1, 2004 – June 30, 2005 . Investigators: Doria A.S. (principal investigator), Dick P. Toronto – ON – Canada

2003 – John Kirkpatrick Young Investigator Award (annual award offered by the Society for Pediatric Radiology for the best paper presented by a fellow). Number of papers: 24.
Title: Which is the best imaging technique for diagnosis of appendicitis in children as compared with adults? A meta-analysis.
Date: May 10, 2003 Doria A.S., Moineddin R., Kellenberger C., Epelman M., Babyn P.S., Dick P., et al. San Francisco – CA – U.S.A.

2002 – John Caffey Award for Basic Science Research (annual award offered by the Society for Pediatric Radiology for the best basic science paper). Number of papers: 98.
Title: Understanding the Functional Angiogenic Process in an Antigen-Induced Arthritis Model: Correlative BOLD MR Imaging (fMRI) of the Stages of Synovitis along the Time Course of the Disease.
Date: May 1, 2002 Doria A.S., Babyn P.S., Crawley A., Noseworthy M., Pritzker K., Salter R.B. Philadelphia – PA – U.S.A.

2001 - Research Training Competition (RESTRACOMP) – Fellowship award – 1st place in category H, Medical degree (with licence) (number of applicants: 8) Agency: The Hospital for Sick Children – Research Institute.
Title: Comparative measurements of BOLD signal in the knee of children with juvenile rheumatoid arthritis (JRA) according to variations in the region-of-interest (ROI)
Date: December 4, 2001 – June 30, 2003 - (18 months). Investigators: Doria A.S. (principal investigator), Dick P. (supervisor) Toronto – ON – Canada

Publications

Zukotynski K, Jarrin J, Babyn PS, Carcao M, Pasmino-Canizares J, Stain AM, Doria AS. Sonography for assessment of hemophilic arthropathy in children: a systematic protocol. Haemophilia 2007; 13 (3): 293-304

Doria AS, Kharshafian R, Moineddin R, Mohanta A, Engelberts D, Zhong A, Pritzker K, Mendes M, Jong R, Burns P. Contrast-enhanced triggered harmonic sonography for assessment of periarticular hemodynamic changes in experimental arthritis. Pediatr Radiol 2006; 36(12):1242-1251

Roposch A, Moreau NM, Uleryk E, Doria AS. Developmental dysplasia of the hip: quality of reporting of diagnostic accuracy for US. Radiology 2006; 241 (3): 854-860

Doria AS, Babyn PS, Lundin B, Kilcoyne RF, Miller S, Rivard G, Moineddin R, Pettersson H. Reliability and construct validity of the compatible MRI scoring system for evaluation of hemophilic knees and ankles of haemophilic children. Expert MRI Working Group of the International Prophylaxis Study Group. Haemophilia 2006; 12 (5): 503-513

Doria AS, Babyn PS, Feldman B. A critical appraisal of radiographic scoring systems for assessment of juvenile idiopathic arthritis. Pediatr Radiol 2006; 36 (8): 759-772

Doria AS, Noseworthy MD, Oakden W, Moineddin R, Rayner T, Tassos V, Engelberts D, Pritzker K, Rogers M, Jong R, Babyn PS. Dynamic contrast-enhanced MRI quantification of synovium microcirculation in experimental arthritis. Am J Roentgenol 2006; 186 (4): 1165-1171

Doria AS, Moineddin R, Kellenberger CJ, Epelman M, Beyene J, Schuh S, Babyn PS, Dick PT. US or CT for diagnosis of appendicitis in children and adults? a meta-analysis. Radiology 2006; 241 (1): 83-94

Doria AS, Daneman A, Moineddin R, Smith CR, Mohanta A, Clarke J, Kellenberger CJ. High-frequency sonographic patterns of the spleen in children. Radiology 2006; 240 (3): 821-827

Holowka S, Doria AS. Scan-timed CT angiography in experimental arthritis: selective placement of regions of interest. Pediatric Radiology 2005; 35(12):1271-1276

Doria AS, Lundin B, Kilcoyne RF, Babyn PS, Miller S, Nuss R, Rivard G, Stephens D, Pettersson H. Reliability of progressive and additive MRI scoring systems for evaluation of haemophilic arthropathy in children: Expert MRI Working Group of the International Prophylaxis Study Group. Haemophilia. 2005;11(3): 245-53

Lundin B, Nuss R, Kilcoyne R, Doria AS, Babyn PS, Miller S, Rivard G, Ljung R, Pettersson H. Compatible scales for progressive and additive magnetic resonance imaging assessments of haemophilic arthropathy. Haemophilia 2005; 11 (2): 109-115

Doria AS, Dick PT. Region-of-interest-based analysis of clustered BOLD MRI data in experimental arthritis. Acad Radiol 2005; 12 (7): 841-852

Doria AS, Castro CC, Kiss MH, Sernik RA, Vitule LF, Silva CHM, Zerbini CAF, Arantes PR, Lucato L, Germano MAN, Cerri GG. Inter- and intra-reader variability in the interpretation of two radiographic classification systems for juvenile rheumatoid arthritis. Pediatr Radiol 2003; 33 (10): 673-681

Doria AS, Babyn PS, Crawley A, Noseworthy M, Pritzker K, Salter RB. Understanding the functional angiogenic process in an antigen-induced arthritis model: correlative BOLD MR Imaging (fMRI) of the stages of synovitis along the time course of the disease. (abstract) Radiology 2002; 225 (P): 379

Doria AS, Babyn PS, Burns P, Kharchakdjian R, Mohanta A, Holowka S. Contrast-enhanced triggered harmonic sonography for quantification of synovial blood flow in an antigen-induced arthritis model: preliminary results of microbubble destruction-reperfusion and wash-in / wash-out curves. Pediatr Radiol 2002; 32 (Suppl. 1): S53

Doria AS, Guarniero R, Cunha FG, Modena M, Godoy Jr. RM, Luzo C, Boelliger Neto R, Molnar LJ, Cerri GG. Contrast-enhanced power Doppler sonography: assessment of revascularization flow in Legg-Calve-Perthes’ disease. Ultrasound Med Biol 2002; 28 (2): 171-182

Doria AS, Guarniero R, Godoy Jr. RM, Buchpiguel C, Modena M, Cunha FG, Luzo C, Molnar LJ, Sapienza MT, Cerri GG. Contrast-enhanced power Doppler US: comparison with scintigraphic phases of revascularization of the femoral head in Legg-Calve-Perthes’ disease. J. Pediatr. Orthop. 2002; 22 (4): 471-478