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About Sickkids
About SickKids

Andrea Doria, MD, PhD, M.Sc.

The Hospital for Sick Children
Clinician Scientist/Staff Radiologist
Diagnostic Imaging

Research Director - Diagnostic Imaging
Diagnostic Imaging

Research Institute
Senior Scientist, Translational Medicine
Research Institute

University of Toronto
Associate Vice-Chair of Research (Injury, Repair, Inflammation)
Dept. of Medical Imaging

Professor of Radiology
Dept. of Medical Imaging

Chair Positions

International Leadership
Special Interest Group in MRI in Juvenile Idiopathic Arthritis
Co-Chair of Outcomes Measures of Rheumatic Diseases (OMERACT)


Phone: 416-813-6079
Fax: 416-813-7591
Email: andrea.doria@sickkids.ca
Alternate Contact: Amanda Clarke
Alternate Phone: 416-813-5175
Alternate Fax: 416-813-7362

Brief Biography

Dr. Andrea Doria received her medical degree from the Universidade Federal do Parana, Brazil, and did her training in Paediatrics and Radiology at the Universidade de Sao Paulo, Brazil. She then received a PhD in medical sciences from the Universidade de Sao Paulo, Brazil. She moved to Canada to pursue a fellowship in Pediatric Radiology and obtained a master’s degree in clinical epidemiology at the University of Toronto. During her fellowship she received the 2002 John Caffey Award for her work on BOLD MRI in experimental arthritis and the 2003 John Kirkpatrick Young Investigator Award for her meta-analysis in appendicitis.  Her passions are: the implementation of innovative analytic methods, processes and strategies that can improve clinical practice, development of evidence-based best practice guidelines that can lead to excellence of patient care, and translation of science and technologies into practices that can transform healthcare delivery. Her teaching interests include the delivery of a course on “Introduction to Research for Radiologists” with the goal of improving the quality of research in radiology.

Academic Background

Projects/ Initiatives:

  1. Use of novel MRI and ultrasound techniques to investigate potential imaging markers that test measurement properties (reliability, validity, responsiveness, sensitivity, specificity). These properties provide a means to track angiogenesis-related factors (cause) and early cartilage degeneration (effect) in musculoskeletal disorders in kids. 
  2. Develops and tests scales for measurement of osteoarticular changes in children both at national and international (collaborative research) levels.
  3. Research program translates innovative experimental and novel MRI and ultrasound techniques into human clinical research.

Research Interests

  • Musculoskeletal imaging (focus: cancer and arthritis): Translation of innovative experimental MRI and ultrasound research methods into clinical practice
  • Radiogenomics: Development of novel integrative clinical-imaging-biochemical paradigms of patients’ outcomes.
  • Data analytics, Artificial Intelligence: Use of machine learning tools to optimize classification of findings, augmentation of data and prediction of disease progression.
  • Technology, Processes and Operations’ Innovation: Using technology for prioritization of activities, forecast of flow of patients throughout the organization and effectiveness maximization at minimum costs and at optimal patients’ satisfaction.

Ongoing Projects/Initiatives

1. Radiogenomics: Personalized Imaging of Arthropathy in Boys with Hemophilia in China (PI: funded by Shire-Baxter BioScience Grant, 2018-2021): By correlating clinical, conventional imaging and novel imaging joint features that lead to unfavourable outcomes we should be able to categorize patients with specific phenotypes into “risk groups” for joint degeneration.
2. Novel Approaches to Molecular and Clinical Surveillance in Li-Fraumeni Syndrome (PI – Project 4: funded by the Terry-Fox Foundation, 2018-2023): Using three novel MRI techniques (whole body inversion recovery MRI, whole body diffusion-weighted MRI and FGD PET-MRI) to determine how sensitive they are at detecting diminutive tumors, and to apply genetic determinants of cancer risk to surveillance and prevention.
3. Imaging of Hypoxia in Childhood Sarcomas: Feasibility Steps Towards Personalized Medicine (PI: funded by the Society of Pediatric Radiology and Garron Family Cancer Centre): Determining the feasibility of using novel/existing imaging technologies focused on hypoxia measurements (BOLD, DWI, MRS, 18F-FAZA PET-MRI) to determine “response to therapy” in pediatric sarcomas.
4. Can Ultrasound “See” What Clinicians Cannot in Hemophilic Arthropathy? Point-of-Care Ultrasound and Physical Examination Perspectives (PI: Access to Insight Clinical Research Grant (Novo Nordisk): Implementing the use of point-of-care ultrasound (POCUS) as an “added value tool” for assessment of joints of patients with hemophilia  in clinical practice by creating an algorithm for diagnostic management of patients based on effective outcomes
according to different clinical situations.
5. Developing and Validating MRI Scales as Outcome Measures in Juvenile Idiopathic Arthritis (JIA): Investigating measurement properties (reliability, validity, responsiveness, sensitivity, specificity) of MRI scales in JIA: Collaborative work through the Pediatric OMERACT group.
6. Testing and Implementing the Use of MRI for Diagnostic of Pediatric Appendicitis (PI: funded by the Physicians’ Incorporation Foundation, 2016-2018): Using an ultrafast 3-Tesla MRI, with excellent patient acceptance, no need for sedation, high sensitivity/specificity, without bearing ionizing radiation. Collaborative work among emergency physicians, emergency room nurses, radiology technologists, radiologists, surgeons, fellows, residents and transportation volunteers.
7. Implementing the Efficiency of a Tertiary Hospital MRI Service: Developing strategies to maximize efficiency of the MRI system by minimizing delays throughout the pipeline of functions of the system, while maintaining high imaging and patient service quality.Future Research 

Her past research contributed to:

(i) Knowledge/Research Advancement: Improved understanding on the biologic rationale for hypoxia in inflamed joints (BOLD MRI) which was translated from animals to humans; proved the feasibility of using novel imaging techniques for quantification of joint bioproducts of arthritis in animals (USPIO; T2 mapping;FDG-PET; dynamic MRI, contrast-enhanced ultrasound [US]) and humans (ultra-short TE; 3DUS and fusion US-MRI).
(ii) Health Care/Outcomes: Recommended approaches for US/MRI data acquisition in childhood arthritis led to the development of US/MRI scales and atlases, which were applied and validated in international research, thus pioneering improvement of diagnosis and follow-up of children with arthritis;
(iii) Health Systems: Led evidence-based knowledge syntheses on diagnostic accuracy of US/MRI for assessment of JIA, hemophilia, osteoporosis, hip dysplasia and appendicitis and participated in the development of evidence-informed policies/guidelines in the field.
(iv) Knowledge Translation: Enabled global dissemination of information on imaging scoring systems and protocols to scientific and patients’ communities through international collaborations with India, Brazil, China, Sweden, Canada, U.S.A. (in hemophilia), and Netherlands, Germany, Switzerland, Norway, Spain, Canada, U.S.A. (in juvenile idiopathic arthritis).

External Funding

Most Recent

2018 The Terry Fox New Frontiers Program Project Grant in the Early Detection and Prevention of Cancer in Li-Fraumeni Syndrome. Terry Fox Foundation. 2018-2023. Malkin D. (Nominated PI), Doria A.S. (PI Project 4). Co-PI: Goldenberg A, Shlien A, Zheng G.

2017 Radiogenomics: Personalized Imaging of Arthropathy in Boys with Hemophilia in China. Baxalta Grants. 2018-2021. PI: Doria AS, Wu R. Co-PI: Zhan N, Peng Y, Hililard P, Blanchette V.

2016 Can Ultrasound “See” What Clinicians Cannot in Hemophilic Arthropathy? Point-of-Care Ultrasound and Physical Examination Perspectives, Access to Insight Clinical Research Grant (Novo Nordisk). 2016-2018. PI: Doria AS. Co-PI: Blanchette V, Hilliard P, Stimec J. 

2016 MRI for Diagnosis of Equivocal Ultrasounds in Suspected Appendicitis: Ultrasound First, MRI Second Approach, Physician’s Services Incorporated (PSI) Foundation. 2016-2018. PI: Doria AS. Co-PI: Schuh S, Wales P, Tomlinson G, Ungar W. 

2015  FAZA Molecular Imaging of Hypoxia in Childhood Sarcomas: Feasibility Steps Towards Personalized Medicine, Garron Family Cancer Centre. 2015-2016 (Extended to 2019 due to Health Canada approval delays). PI: Doria AS. Co-PI: Shammas A, Vali R, Gupta A. Malkin D, Fisher J, Cheng HL, Somers G, Moineddin R.

2014  Functional MR Imaging of Hypoxia in Childhood Sarcomas: Feasibility Steps Towards Personalized Medicine, Society of Pediatric Radiology.  2015-2016 (Extended to 2019 due to Health Canada approval delays). Doria AS,  Shammas A, Vali R, Gupta A, Malkin D, Fisher, J, Cheng HL, Somers, G, Moineddin, R.
 

Achievements

2017  Sloan Leadership Fellowship Award: Massachusetts Institute of Technology (MIT) Sloan School of Management, Cambridge, MA. US$ 12,500

2016  Faculty Research Award: Department of Medical Imaging, University of Toronto. On-line voting system by residents, fellows and staff of the Department of Medical Imaging, University of Toronto  (The Hospital for Sick Children, Toronto General Hospital, Mount Sinai Hospital, St Michael’s Hospital, Toronto Western Hospital and Sunnybrook Hospital) – 1 annual award offered by the Department of Medical Imaging, University of Toronto

2016  Excellence in Teaching Award: Department of Medical Imaging, University of Toronto. On-line voting system by residents and fellows of the Department of Medical Imaging, University of Toronto  (The Hospital for Sick Children, Toronto General Hospital, Mount Sinai Hospital, St Michael’s Hospital, Toronto Western Hospital and Sunnybrook Hospital)

2014  Research featured on the 2014 January magazine, ARRS InPractice, of the American Journal of Roentgenology: Munir S, Twilt M, Miller E, Spiegel L, Uleryk E, Doria A.S. Evidence-Based Outcomes of Studies Addressing Diagnostic Accuracy of MR Imaging of The Axial Skeleton in Juvenile Idiopathic Arthritis. AJR 2014; 202(1): 199-210.

2011  Honorable Mention for Best Basic Science Paper. Title: Assessment of Cortical Bone Loss with Quantitative Ultrasound, Peripheral CT and Micro-CT in Post Mortem Knee Specimens of a Rabbit Model of Inflammatory Arthritis. Date: May 27-31, 2011. Amirabadi A, Wang J, Gordon C, Tomlinson C, Grynpas M, Moineddin R, Doria A.S. London, England

2011  XXII Congress of the International Society of Thrombosis and Haemostasis - Kyoto, Japan. Lundin B, Manco-Johnson ML, Ignas D, Doria A.S. An MRI scale for Assessment of Hemophilic Arthropathy. International Prophylaxis Study Group. The work has been presented as a poster at the International Society of Thrombosis and Haemostasis (ISTH) Conference in Kyoto, Japan, July 2011, and was assigned a ribbon reward for being among the top 15% abstracts.

2010  Poster Award (1 of 10 finalists in the General Clinical Specialties track for a poster award) at the 57th Annual Meeting of the Society of Nuclear Medicine. Title: Pilot study of FDG PET/CT for Hemophilic Arthropathy in a Rabbit Model. Date: June 8, 2010. Shammas A, Doria A.S., Charron M, Metser U. Salt Lake City – Utah – U.S.A.

2009  Research featured on the website of the February 2009, volume 250, issue 2 of Radiology: Wan M.J., Krahn M., Ungar W., Sung L., Doria A.S. Acute Appendicitis in Young Children: Cost-effectiveness of US versus CT in Diagnosis--A Markov Decision Analytic Model. Radiology 2008; 250 (2):378-386.

2009  Speaker at the U.S.A. ReachMD podcast in 2009 on “Cost and Risk Analysis for Imaging of Acute Appendicitis in Children” from the series on Advanced in Medical Imaging.

2008  Excellence in Teaching Award: Department of Medical Imaging, University of Toronto

2006  Canadian Child Health Clinician-Scientist Program – Career Development Award.
Canadian Institutes of Health Research, Sick Kids Foundation and British Columbia Children’s Hospital Foundation.
July 1, 2006 – 4 year period

2005  Seed Grant Funding – Department of Medical Imaging - University of Toronto
Title: Paediatric Musculoskeletal Imaging
Jan 21, 2005 - 3 year period

2004  Chair’s Start-up Fund.
Title: Functional MR imaging assessment of therapeutic outcomes in experimental arthritis. Date: October 13, 2004. Toronto – ON – Canada

2004  Medical Imaging Research and Development Award.
Title: Comparative measurements of BOLD signal in experimental arthritis according to variations in the region-of-interest.
Date: July 1, 2004 – June 30, 2005 . Investigators: Doria A.S. (principal investigator), Dick P. Toronto – ON – Canada

2003  John Kirkpatrick Young Investigator Award (annual award offered by the Society for Pediatric Radiology for the best paper presented by a fellow). Number of papers: 24.
Title: Which is the best imaging technique for diagnosis of appendicitis in children as compared with adults? A meta-analysis.
Date: May 10, 2003 Doria A.S., Moineddin R., Kellenberger C., Epelman M., Babyn P.S., Dick P., et al. San Francisco – CA – U.S.A.

2002  John Caffey Award for Basic Science Research (annual award offered by the Society for Pediatric Radiology for the best basic science paper). Number of papers: 98.
Title: Understanding the Functional Angiogenic Process in an Antigen-Induced Arthritis Model: Correlative BOLD MR Imaging (fMRI) of the Stages of Synovitis along the Time Course of the Disease.
Date: May 1, 2002 Doria A.S., Babyn P.S., Crawley A., Noseworthy M., Pritzker K., Salter R.B. Philadelphia – PA – U.S.A.

2001  Research Training Competition (RESTRACOMP) – Fellowship award – 1st place in category H, Medical degree (with licence) (number of applicants: 8) Agency: The Hospital for Sick Children – Research Institute.
Title: Comparative measurements of BOLD signal in the knee of children with juvenile rheumatoid arthritis (JRA) according to variations in the region-of-interest (ROI)
Date: December 4, 2001 – June 30, 2003 - (18 months). Investigators: Doria A.S. (principal investigator), Dick P. (supervisor) Toronto – ON – Canada

1986  Public contest for entrance at the University : First place in Medicine - Third place in the general contest (total number of applicants: 10,048). Pontificia Universidade Católica do Paraná - Curitiba - PR – Brazil

Publications

Past 3 years

Accepted for Publication:

Swami VG, Jaremko JL, Rumsey D, Stimec J, Tse S, Otobo T, Adams-Webber T, Doria A.S. Diagnostic accuracy of MRI-based sacroiliitis scoring systems: a systematic review. AJR 2018 In Press  SRI

Fischer K, Poonnoose P, Dunn A, Babyn P, Manco-Johnson M, John J, van der Net J, Feldman B, Berger, K, Carcao M, de Kleijn P, Silva M, Hilliard P, Doria A.S., Srivastava A, Blanchette V. Choosing outcome assessment tools in haemophilia care and research: a multidisciplinary perspective. Haemophilia 2018 In Press C

Nusman CM, de Horatio LT, Hemke R, van Gulik EC, Ording Müller LS, Malattia C, Avenarius D, Toma P, Roth J, Tzaribachev N, Magni-Manzoni S, Maas M, Doria A.S., Rosendahl K. Imaging in Juvenile Idiopathic Arthritis – International Initiatives and Ongoing Work. Pediatr Radiol 2018 Jan 13  C

Eng KA, Abadeh A, Ligocki C, Lee YK, Moineddin R, Adams-Webber T, Schuh S, Doria AS. Acute Appendicitis: A Meta-Analysis of the Diagnostic Accuracy of US, CT, and MRI as Second-Line Imaging Tests after an Initial US. Radiology 2018 Jun 19:180318. doi: 10.1148/radiol.2018180318. [Epub ahead of print]  SRI

Junhasavasdikul T, Aryan A, Tolend M, Doria A.S.  Developing a Reference Database for Temporomandibular Joints in Healthy Children and Adolescents. Pediatr Radiol 2018; 48(8):1113-1122  SRI

Hemke R, Tzaribachev N, Barendregt AM, Merlijn van den Berg J, Doria AS, Maas M. Imaging of the knee in juvenile idiopathic arthritis. Pediatr Radiol 2018;48(6):818-827  C

Nusman CM, de Horatio LT, Hemke R, van Gulik EC, Ording Müller LS, Malattia C, Avenarius D, Toma P, Roth J, Tzaribachev N, Magni-Manzoni S, Maas M, Doria AS, Rosendahl K. Imaging in juvenile idiopathic arthritis - international initiatives and ongoing work. Pediatr Radiol 2018;48(6):828-834  C

Miller E, Inarejos Clemente EJ, Doria A.S., Kellenberger C, Larheum TA. Imaging of Temporomandibular Joint Abnormalities in Juvenile Idiopathic Arthritis with a Focus on Development of a Magnetic Resonance Imaging Protocol. Pediatr Radiol 2018 48(6):792-800  C

Inarejos Clemente EJ, Tolend M, Junhasavasdikul T, Stimec J, Tzaribachev N, Koos B, Spiegel L, Moineddin R, Doria A.S. Qualitative and Semi-Quantitative Assessment of Temporomandibular Joint MRI Protocols for Juvenile Idiopathic Arthritis at 1.5 and 3.0 Tesla. Eur J Radiol 2018;98:90-99 SRI

Tolend MA, Twilt M, Cron RQ, Tzaribachev N, Guleria S, von Kalle T, Koos B, Miller E, Stimec J, Vaid Y, Larheim TA, Herlin T, Spiegel L, Inarejos E, Moineddin R, van Rossum MA, Saurenmann RK, Doria A.S.*, Kellenberger CJ. Toward Establishing a Standardized Magnetic Resonance Imaging Scoring System for Temporomandibular Joints in Juvenile Idiopathic Arthritis.  Arthritis Care Res (Hoboken). 2017 Aug 13  SRI
*Shared Senior Authorship

 Kellenberger CJ, Junhasavasdikul T, Tolend M, Doria A.S. Temporomandibular joint atlas for detection and grading of juvenile idiopathic arthritis involvement by magnetic resonance imaging. Pediatr Radiol 2018;48(3):411-426  SRI

Chauvin N, Doria A.S. Ultrasound Imaging of Juvenile Idiopathic Arthritis. Pediatr Radiol 2017;47(9):1160-1170  SRI

Ligocki C, Abadeh A, Wang K, Adams-Webber T, Blanchette V, Doria A.S. A Systematic Review of Ultrasound Imaging as a Tool for Evaluating Hemophilic Arthropathy in Children and Adults. Haemophilia 2017; 23(4):598-612  SRI

Soliman M, Daruge P, Dertkigil S, De Avila Fernandes E, Negrao J, de Aguiar Vilela Mitraud S, da Rocha ACF, Zhang N, Huo A, Li Y-J, Zhou F, Bordalo-Rodrigues M, Mohanta A, Blanchette V, Doria A.S. Imaging of Hemophilic Arthropathy in Growing Joints: Pitfalls in Ultrasound and MRI. Haemophilia 2017;23(5):660-672  SRI

Hemke R, Tzaribachev N, Nusman CM, van Rossum MAJ, Maas M, Doria A.S. Magnetic Resonance Imaging (MRI) of the Knee as an Outcome Measure in Juvenile Idiopathic Arthritis: An OMERACT Reliability Study on MRI Scales. J Rheumatol 2017;44(8):1224-1230.

Church PC, Greer MC, Cytter-Kuint R, Doria AS, Griffiths AM, Turner D, Walters TD, Feldman BM. Magnetic resonance enterography has good inter-rater agreement and diagnostic accuracy for detecting inflammation in pediatric Crohn disease. Pediatr Radiol 2017;47(5):565-575  C

Berntorp E, Dargaud Y, Hart D, Lobet S, Mancuso ME, d’Oiron R, Perry D, Pollard D, van den Berg M, Blatný J, Chambost H, Doria A.S., Holme PA, Kaczmarek R, Mantovani L, McLaughlin P, Nanayakkara L, Petrini P, Sannié T, Laane E, Maia R, Dettoraki A, Farrell A, Halimeh S, Raza S, Taylor S. The Second Team Haemophilia Education (THE) Meeting, 2016, Frankfurt, Germany. Eur J Haematol 2017; 98 Suppl 85:1-15  C

Zhylich D., Krishnan P., Muthusami P., Rayner-Kunopaski T., Shroff M.M., Doria A.S., Tompson B., Lou W., Suri S. Effects of orthodontic appliances on diagnostic quality of MR images of the head. Am J Orthod Dentofacial Orthop 2017;151(3):484-499 C

Shammas A, Doria A.S., Amirabadi A, Gahunia H, Jong R, Charron M, Moineddin R, Metser U. Pilot study on 18 F-FDG PET/CT for detection of inflammatory changes in blood-induced knee arthropathy in a rabbit model. Haemophilia 2017;23(1):e25-e32  CPA

Poonnoose PM, Hilliard P, Doria A.S., Keshava SN, Gibikote S, Kavitha ML, Feldman BM, Blanchette V, Srivastava A. Correlating clinical and radiological assessment of joints in haemophilia: results of a cross sectional study. Haemophilia 2016 22(6):925-933   C

McKinney J, Sussman M, Moineddin R, Amirabadi A, Rayner T, Doria A.S. Accuracy of MRI Sequences for Measurements of Maturing Cartilage: a Phantom Study. Clinics (Sao Paulo) 2016; 71(7):404-411. SRI

Doria A.S., Keshava S, Gibikote S. Hemosiderin Detection with Ultrasound: Reality or Myth? Reply to a Letter to the Editor. Am J Roentgenol 2016;2 06(1):W31-35  SRI

Daldrup-Link HE, Sammet C, Hernanz-Schulman M, Barsness KA, Cahill AM, Chung E, Doria A.S., Darge K, Krishnamurthy R, Lungren MP, Moore S, Olivieri L, Panigrahy A, Towbin AJ, Trout A, Voss S. White Paper on P4 Concepts for Pediatric Imaging. J Am Coll Radiol 2016;13(5):590-597.e2.   C

Larheim T, Doria A.S., Kirkus E, Parra D, Kellenberger C, Arvidsson LZ. TMJ imaging in JIA patients - An overview.  Seminars in Orthodontics 2015;21(2), s 102- 110  CPA

Ma, Grace, Amirabadi A, Inarejos E, Moineddin R, Tolend M, Spiegel L, Doria A.S. MRI Thresholds for Discrimination between Normal and Mild Temporomandibular Joint Involvement in Juvenile Idiopathic Arthritis. Pediatr Rheumatol 2015; 13(1):53 SRI

Wang KC, Amirabadi A, Wang KC, Zhong A, Moineddin R, Jong R, Moineddin R, Doria A.S. Longitudinal Assessment of Bone Loss Using Quantitative Ultrasound in a Blood-Induced Arthritis Rabbit Model. Haemophilia 2015; 5:e402-410 SRI

Soliman M, Laxer R, Manson D, Doria A.S. Imaging of Systemic Vasculitis in Childhood. Pediatr Radiol 2015; 45(8):1110-1125  SRI

Schuh S, Chan K., Langer J.C., Kulik D., Preto-Zamperlini M, Al-Aswad N, Man C., Mohanta A., Stephens D., Doria A.S. Diagnostic Properties of Serial Ultrasound Diagnostic Clinical Pathway in Suspected Appendicitis and Related CT Use. Acad Emerg Med 2015; 22: 406-414  SRI

Takrouri H., Al-Nassar M., Amirabadi A., Babyn P.S., Moineddin R., Padfield N., Doria A.S. Metallic Artifact Reduction: the Added Value of Rapid KvP Switching Dual Energy CT in Relation to Single Energy CT in a Piglet Animal Model. AJR Am J Roentgenol 2015, 205(3):W352-359  SRI