About Sickkids
About SickKids
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Andrea Doria , MD, PhD, MSc

The Hospital for Sick Children
Clinician Scientist/Staff Radiologist
Diagnostic Imaging

Research Director - Diagnostic Imaging
Diagnostic Imaging

Research Institute
Scientist
Physiology & Experimental Medicine

University of Toronto
Co-Director of Research (Fellowship Program)
Dept. of Medical Imaging

Associate Professor of Radiology
Dept. of Medical Imaging

Chair of Clinical Investigator Program (CIP)
Dept. of Medical Imaging


Phone: 416-813-6079
Fax: 416-813-7591
e-mail: andrea.doria@sickkids.ca
Alternate Contact: Seetha Sriharan
Alternate Phone: 416-813-5175
Alternate Fax: 416-813-7362
Alternate e-mail: seetha.sriharan@sickkids.ca

Brief Biography

Dr. Andrea Doria received her medical degree from the Universidade Federal do Parana, Brazil, and did her training in Paediatrics and Radiology at the Universidade de Sao Paulo, Brazil. She then received a PhD in medical sciences from the Universidade de Sao Paulo, Brazil. She moved to Canada to pursue a fellowship in Paediatric Radiology and obtained a master’s degree in clinical epidemiology at the University of Toronto. During her fellowship she received the 2002 John Caffey Award for her work on BOLD MRI in experimental arthritis and the 2003 John Kirkpatrick Young Investigator Award for her meta-analysis in appendicitis.

Her passion is the investigation of potential imaging markers to track angiogenesis-related factors (cause) and early cartilage degeneration (effect) in arthritis.

Her teaching interests include the development and implementation of a course on “Introduction to Research for Radiologists” with the goal of improving the quality of research in radiology.

Academic Background

Projects/ Initiatives:

  1. Use of novel MRI and ultrasound techniques to investigate potential imaging markers that test measurement properties (reliability, validity, responsiveness, sensitivity, specificity). These properties provide a means to track angiogenesis-related factors (cause) and early cartilage degeneration (effect) in musculoskeletal disorders in kids. 
  2. Dr. Doria develops and tests scales for measurement os osteoarticular changes in children both at national and international (collaborative research) levels.
  3. Her research program translates innovative experimental and novel MRI and ultrasound techniques into human clinical research.

Research Interests

  • Musculoskeletal imaging
  • Ultrasound and MR imaging
  • Angiogenesis

Research Activities 

Dr. Doria's main research interests are:

  • to test measurement properties (reliability, validity, responsiveness, sensitivity, specificity) of novel MRI and ultrasound techniques for evaluation of musculoskeletal disorders in the paediatric population
  • to develop and test scales for measurement of osteoarticular changes in children

Future Research 

Her future research goals are:

  • to help develop international standards for data acquisition and interpretation of imaging modalities on pediatric musculoskeletal disorders.
  • to implement and refine existing imaging techniques available for assessment of musculoskeletal disorders, making them accessible for developed and developing countries according to the realities of their health care systems.

External Funding

Most Recent

2010-2015 - External Validation of Ultrasound as a Diagnostic Tool for Assessment of Hemophilic Arthropathy of Knees and Knees, MRI Correlation, Baxter Healthcare Corporatrion (2 years). PI: Doria AS. Co-investigators: Blanchette V, Feldman B.

2011-2014 - Novel Imaging Techniques for Assessment of Early Cartilage and Soft Tissue Changes in Hemophilic Ankles, Canadian Hemophilia Society. Dream for a Cure Award. PI: Doria AS. Co-investigators: Fenster A, Sussman M, Blanchette V.

2012-2013 - Towards Developing MR Imaging Guidelines and Outcome Measures in Juvenile Idiopathic Arthritis: A Special Interest Pediatric Research Group. Canadian Institutes of Health Research (CIHR) - Musculoskeletal Health and Arthritis Institute. PI: Doria AS.  Co-investigators: Van Rossum MA, Yeung R, Benseler S, Stinson J, Tse S.

2011-2013 - Diagnostic Accuracy of an Imaging Pathway in Suspected Pediatric Appendicitis.  Physicans' Services Incorporated Foundation. PI: Doria SA.  Co-investigators: Schuh S (Co-PI), Langer J, Tomlinson G.

2009-2011 - Measurement Properties of Ultrasound for Assessment of Hemophilic Arthropathy. MRI Correlation - Normal Subjects. Bayer Health Care. Partnership Fund. PI: Doria SA. Co-investigators: .Srivastava A, Gibikote S, Keshava SN, Poonnoose P, Blanchette V, Babyn P, Alman B, Moineddin R, Hilliard P

2007-2011 - Functional-Molecular MR Imaging for Physiologic Characterization and Cartilage Damage Prediction in a Rabbit Model of Hemophilic Arthropathy. Bayer Health Care. Partnership Fund. PI: Doria AS. Co-investigators: Cheng H-L, Miller E, Sussman M, White L, Babyn P, Gahunia P, Peel S, Yeung R, Alman B, Moineddin R, Blanchette V.

2006-2009 - Measurement Properties of Ultrasound for Assessment of Hemophilic Arthropathy. MRI Correlation. Bayer Health Care.  Partnership Fund.  PI: Doria AS. Co-investigators: Srivastava A, Gibikote S, Keshava SN, Poonnoose P, Blanchette V, Babyn P, Alman B, Moineddin R, Hilliardk P.

2006-2007 - Functional MR Imaging for Early Detection and Physiologic Characterization of Inflammatory Arthritis in a Rabbit Model. Radiologic Society of North America. PI: Doria AS. Co-investigators: Belik J, Kassner A, Cheng H-L, Crawley A, Yeung R, Tomlinson G.

Achievements

2011 – Honorable Mention for Best Basic Science Paper. Title: Assessment of Cortical Bone Loss with Quantitative Ultrasound, Peripheral CT and Micro-CT in Post Mortem Knee Specimens of a Rabbit Model of Inflammatory Arthritis. Date: May 27-31, 2011. Amirabadi A, Wang J, Gordon C, Tomlinson C, Grynpas M, Moineddin R, Doria A.S. London, England

2011 - XXII Congress of the International Society of Thrombosis and Haemostasis - Kyoto, Japan. Lundin B, Manco-Johnson ML, Ignas D, Doria A.S. An MRI scale for Assessment of Hemophilic Arthropathy. International Prophylaxis Study Group. The work has been presented as a poster at the International Society of Thrombosis and Haemostasis (ISTH) Conference in Kyoto, Japan, July 2011, and was assigned a ribbon reward for being among the top 15% abstracts.

2010 – Poster Award (1 of 10 finalists in the General Clinical Specialties track for a poster award) at the 57th Annual Meeting of the Society of Nuclear Medicine. Title: Pilot study of FDG PET/CT for Hemophilic Arthropathy in a Rabbit Model. Date: June 8, 2010. Shammas A, Doria A.S., Charron M, Metser U. Salt Lake City – Utah – U.S.A.

2008 - Excellence in Teaching Award: Department of Medical Imaging, University of Toronto

2006 - Canadian Child Health Clinician-Scientist Program – Career Development Award.
Canadian Institutes of Health Research, Sick Kids Foundation and British Columbia Children’s Hospital Foundation.
July 1, 2006 – 4 year period

2005 – Seed Grant Funding – Department of Medical Imaging - University of Toronto
Title: Paediatric Musculoskeletal Imaging
Jan 21, 2005 - 3 year period

2004 – Chair’s Start-up Fund.
Title: Functional MR imaging assessment of therapeutic outcomes in experimental arthritis. Date: October 13, 2004. Toronto – ON – Canada

2004 – Medical Imaging Research and Development Award.
Title: Comparative measurements of BOLD signal in experimental arthritis according to variations in the region-of-interest.
Date: July 1, 2004 – June 30, 2005 . Investigators: Doria A.S. (principal investigator), Dick P. Toronto – ON – Canada

2003 – John Kirkpatrick Young Investigator Award (annual award offered by the Society for Pediatric Radiology for the best paper presented by a fellow). Number of papers: 24.
Title: Which is the best imaging technique for diagnosis of appendicitis in children as compared with adults? A meta-analysis.
Date: May 10, 2003 Doria A.S., Moineddin R., Kellenberger C., Epelman M., Babyn P.S., Dick P., et al. San Francisco – CA – U.S.A.

2002 – John Caffey Award for Basic Science Research (annual award offered by the Society for Pediatric Radiology for the best basic science paper). Number of papers: 98.
Title: Understanding the Functional Angiogenic Process in an Antigen-Induced Arthritis Model: Correlative BOLD MR Imaging (fMRI) of the Stages of Synovitis along the Time Course of the Disease.
Date: May 1, 2002 Doria A.S., Babyn P.S., Crawley A., Noseworthy M., Pritzker K., Salter R.B. Philadelphia – PA – U.S.A.

2001 - Research Training Competition (RESTRACOMP) – Fellowship award – 1st place in category H, Medical degree (with licence) (number of applicants: 8) Agency: The Hospital for Sick Children – Research Institute.
Title: Comparative measurements of BOLD signal in the knee of children with juvenile rheumatoid arthritis (JRA) according to variations in the region-of-interest (ROI)
Date: December 4, 2001 – June 30, 2003 - (18 months). Investigators: Doria A.S. (principal investigator), Dick P. (supervisor) Toronto – ON – Canada

Publications

Chan M.W., Xavier F., Blanchette V., Doria A.S. MR Imaging as a screening tool for early detection of arthropathy in hemophilic children. systematic review and recommendations.  Haemophilia 2013 Aug In Press   SRI (Senior Author)

Munir S., Twilt M., Miller E., Spiegel L., Uleryk E., Doria A.S. Evidence-based outcomes of studies addressing diagnostic accuracy of MR imaging of the axial skeleton in juvenile idiopathic arthritis. AJR 2013 In Press  SRI

Doria AS. Abdominal pain duration impacts the accuracy of ultrasound for diagnosing paediatric appendicitis. Evid Based Med. 2013 Mar 1. [Epub ahead of print]

Doria A.S., Crawley A., Babyn P., Rayner T., Feldman B. BOLD MRI at 1.5 tesla in juvenile idiopathic arthritis: preliminary experience. Clinics 2013; 68(5): 721-724   PA (Primary Author)

Kraft JK, Blanchette VS, Babyn PS, Cloutier S, Feldman BM, Israels SJ, Klaassen R, Pai MK, Poon MC, Price V, Rivard G, Wu J, Gomer S, McLimont M, Moineddin R, Doria AS. Magnetic resonance imaging and joint outcomes in boys with severe hemophilia A treated with tailored primary prophylaxis in Canada. J Thromb Haemost 2012;10(12):2494-2502  SRI

Lundin B, Manco-Johnson ML, Ignas DM, Moineddin R, Blanchette VS, Dunn AL, Gibikote SV, Keshava SN, Ljung R, Manco-Johnson MJ, Miller SF, Rivard GE, Doria A.S.; The International Prophylaxis Study Group. An MRI scale for assessment of haemophilic arthropathy from the International Prophylaxis Study Group. Haemophilia 2012;18(6):962-970  SRI

Nasui C, Nathanael G, Miller E, Belik J, Crawley A, Weiss R, Detzler G; Zhong A; Moineddin R, Doria AS. Responsiveness of BOLD MRI to short-term temperature changes in rabbit knees with inflammatory arthritis. Rheumatology (Current Research) 2012 ISSN: 2161-1149 (Suppl 2):1-9  SRI.

Xavier F, Zhang N, Mohanta M, Hilliard P, Man C, Drossmann D, Stain AM, Blanchette V, Doria AS. Sonography for assessment of elbows in haemophilic children: a systematic protocol.  Rheumatology (Current Research) 2012 ISSN: 2161-1149 (Suppl 2):1-9  SRI.

Monahan PE, Doria A.S., Ljung R, Jimenez-Yuste V. Optimizing joint function: new knowledge and novel tools and treatments. Haemophilia 2012; 18 (Suppl 5):17-26  CPA (Co-Primary Author)

Miller E, Daneman A, Doria AS, Blaser S, Traubici J, Jarrin J, Moineddin R, Moore A, Shroff M. Color doppler ultrasound of cerebral venous sinuses in neonates: a comparison with MR venography. Pediatr Radiol 2012; 42(9):1070-1079  C (Collaborator)

Pope E, Doria AS, Theriault M, Mohanta A, Laxer RM. Topical imiquimod 5% cream for pediatric plaque morphea: a prospective, multiple-baseline, open-label pilot study. Dermatology 2011; 223(4):363-369  CPA

Doria AS, Crawley A, Gahunia H, Moineddin R, Rayner T, Tassos V, Zhong A, Pritzker K, Mendes M, Jong R, Salter RB. Correlative BOLD MR imaging of stages of synovitis in a rabbit model of antigen-induced arthritis. Pediatr Radiol 2012; 42(1): 63-75  PA (Primary Author)

Doria A.S., Wang Chenghua, Zhong A, Rayner T, Belik J, Moineddin R, Crawley A. Reliability and convergent validity of different BOLD MRI frameworks for data acquisition in experimental arthritis. Acad Radiol 2011; 18(5): 615-626    PA

Odeh O, Wedge J, Doria A.S., Roposch A. The presence of an ossific nucleus does not protect against osteonecrosis after treatment of developmental dysplasia of the hip. Clin Orthop Rel Res 2011 in press  Feb 11  C

Sulowski C, Doria A.S., Langer J., Stephens J.C., Schuh S.  Clinical outcomes in obese children with suspected appendicitis. Acad Emerg Med 2011; 18: 167-173   CPA
16. Schuh S., Man C., Cheng A., Murphy A., Mohanta A., Moineddin R., Tomlinson G., Langer J.C., Doria A.S. Predictors of non-diagnostic ultrasound in children with suspected appendicitis. J Pediatr 2011; 158: 112-118    SRI

Doria A.S. State-of-the-art imaging techniques for evaluation of hemophilic arthropathy: present and future. Haemophilia 2010; Suppl 5: 107-114  PA

Li S., Liebling M.S., Ramji F., Opitz S., Mohanta A., Kornyat T., Zhang S., Dempsey-Robertson M., Hamer C., Edgerton S., Jarrin J., Malone M., Doria A.S. Sonographic evaluation of pediatric localized scleroderma: preliminary disease assessment measures. Pediatr Rheumatol 2010, 8:14  SRI

Silva CT, Doria A.S., Traubici J, Moineddin R, Davila J, Shroff M. Do additional views improve the diagnostic performance of cervical spine radiography in pediatric trauma? AJR Am J Roentgenol. 2010; 194 (2): 500-508  CPA    *Doria A.S.: Correspondent Author

Doria A.S., Chaudry GA, Nasui C, Rayner T, Wang C, Moineddin R, Babyn PS, White LM, Sussman MS. The use of parallel imaging for MRI assessment of knees in children and adolescents. Pediatr Radiol 2010; 40 (3): 284-293  PA

Khan U, Bogue C, Ungar WJ, Hilliard P, Carcao M, Moineddin R, Doria A.S. Cost-effectiveness analysis of different imaging strategies for diagnosis of haemophilic arthropathy. Haemophilia 2009; 16 (2): 322-332   SRI

Keshava, S., Gibikote, S., Mohanta A., Doria A.S.  Refinement of a Sonographic Protocol for Assessment of Haemophilic Arthropathy. Haemophilia 2009; 15 (5): 1168-1171  SRI

Junqueira B.L.P., Allen L.M., Spitzer R.F., Lucco K.L., Babyn P.S., Doria A.S.  Müllerian duct anomalies and mimics in children and adolescents: correlative intraoperative assessment with clinical imaging. Radiographics 2009; 29: 1085-1103   SRI

Miller E., Uleryk E., Doria A.S. Evidence-based outcomes of studies addressing diagnostic accuracy of MR imaging of juvenile idiopathic arthritis. Am J Roentgenol 2009; 192 (5): 1209-1218  SRI

Miller E., Roposch A., Uleryk E., Doria A.S. Juvenile idiopathic arthritis: quality of reporting of diagnostic accuracy for MRI. Acad Radiol 2009; 16 (6): 739-757  SRI

Ortiz-Neira C., Laffan E., Roposch A., Ohlsson A., Fong K., Babyn P., Doria A.S. Color doppler ultrasound assessment of the normal neonatal hip. Can Assoc Radiol J 2009; 60 (2): 79-87   SRI

Doria A.S. Optimizing the role of imaging in appendicitis. Pediatr Radiol 2009; 39 (Suppl 2):S144–S148  PA.

Wan M.J., Krahn M., Ungar W., Sung L., Doria A.S.. Acute appendicitis in young children: cost-effectiveness of US versus CT in diagnosis--a Markov decision analytic model. Radiology 2008; 250 (2):378-386  SRI.  

Mauser-Bunschoten EP, Jansen NW, Doria A.S.,  Oldenburg  J. New images in haemophilia. Haemophilia 2008; 14 Suppl 3:147-152   C.

Feldman BM, Funk, S., Lundin B., Doria A.S., LJung R., Blanchette V. Musculoskeletal measurement tools from the International Prophylaxis Study Group (IPSG).  Haemophilia 2008;14 Suppl 3:162-9