Denis Daneman, MB, BCh, FRCP(C)
The Hospital for Sick Children
Senior Associate Scientist
Child Health Evaluative Sciences
University of Toronto
Department of Paediatrics
The R.S. McLaughlin Foundation Chair in Paediatrics
Dr. Denis Daneman, MB, BCh, FRCP(C), joined SickKids as a resident in paediatrics in 1975 and as a staff endocrinologist in 1981. He was named Paediatrician-in-Chief in 2006.
The Chief Paediatrician is the leading physician at SickKids. The incumbent holds the R.S. McLaughlin Foundation Chair in Paediatrics and is Chair of Paediatrics at the University of Toronto.
From 1992 to 2006 Dr. Daneman served as Head of the Division of Endocrinology, and from 2000 to 2005 he was Associate Chief of Research (Clinical). His clinical care activities are comprehensive tertiary care of children and teens with diabetes, and care of children with endocrine disorders. His research focuses on factors affecting metabolic control and the early onset of complications in children and teens with type-1 diabetes. Other research interests include diabetes mellitus, insulin resistance, eating disorders, microvascular complications, health care delivery to youth with diabetes, and early diabetic nephropathy.
He received his medical degree at University of Witwatersrand, Johannesburg, South Africa, and trained in paediatrics and paediatric endocrinology at The Hospital for Sick Children and at Children’s Hospital of Pittsburgh.
Clinical Care Activities
- comprehensive tertiary care of children and teens with diabetes
- care of children with endocrine disorders.
- diabetes mellitus
- insulin resistance
- eating disorders
- microvascular complications
- health care delivery
My research focuses on factors affecting metabolic control and the early onset of complications in children and teens with type-1 diabetes.
Specific areas of interest include: (i) insulin resistance and its modification in teens with diabetes; (ii) the association between type 1 diabetes and eating disorders in adolescent girls; (iii) early micro- and macrovascular changes in these teens; and (iv) health care delivery to youth diabetes.
Future Research Interests
- Ongoing studies of eating disorders in teenage girls with diabetes
- School attendance in children with diabetes
- Factors affecting metabolic control
- Early diabetic nephropathy
2005-2006 Serono Canada unrestricted grant: Final adult height in children with idiopathic growth hormone deficiency treated with growth hormone. (D. Daneman PI)
2005-2006 Lawson Foundation: The “Over 10” Program at the Hospital for Sick Children Diabetes Clinic (D Daneman, PI; Marcia Frank, Margo Small, Co-Investigators)
2003-2006 CIHR: A longitudinal study of eating disturbances, psychosocial functioning and medical complications in adolescent girls and young women with type 1 diabetes mellitus. (PI: G Rodin, Co-Is: P Colton, D Daneman, M Olmsted)
2003-2005 CIHR: Diabetes Surveillance System. Validation of administrative data algorithms for diabetes surveillance in special populations. (PI: J Hux; Co-I’s D Daneman, G Booth, D Feig, A Hanley, H Lee, T To)
2002-2004 Eli Lilly Canada and Nova Scotia Health Research Foundation: Use of Pioglitazone as an adjunct to insulin therapy in adolescents with type 1 diabetes. (Co-PI’s: Denis Daneman, Beth Cummings (Halifax) and Jill Hamilton).
July 2001-2008 National Institutes of Health: TrialNet Center (Study group for prevention of type 1 diabetes). PI Diane Wherrett, CoPIs: D Daneman, J Mahon.
Aanstoot H-J, Anderson BJ, Daneman D, Danne T, Donaghue T, Kaufman F, Réa RR, Uchigata Y. The Global Burden of Youth Diabetes: Perspectives and Potential. A Charter Paper. Pediatric Diabetes 8(Supplement 8):1-44, 2007.
Colton P, Olmsted M, Daneman D. Rydall A, Rodin G. 5-Year Prevalence and Persistence of Disturbed Eating Behavior and Eating Disorders in Girls with Type 1 Diabetes. Diabetes Care 30:2861-2, 2007.
Rachmiel, M, Buccino J, Daneman D. Exercise and diabetes mellitus type 1 in youth; review and recommendations. Ped Endo Reviews 5:656-65; 2007
Cameron FJ, Northam EA, Ambler GR, Daneman D. Routine psychological screening in youth with type 1 diabetes and their parents: a notion whose time has come? Diabetes Care 30: 2716-2724, 2007
Dunger D, et al, including Daneman D. Should we be identifying adolescents at high risk for nephropathy and cardiovascular disease before the development of microalbuminuria? Diabetic Medicine 24:131-6, 2007
Conwell L, Forrest C, Allen U, Daneman D. Necrotizing Fasciitis in Adolescents with Poorly Controlled Type 1 Diabetes Mellitus:- Report of 2 cases. Pediatric Diabetes 8: 397-400, 2007.
Colton P, Olmsted M, Daneman D, Rydall A, Rodin G. Natural history and predictors of eating disturbances in girls with type 1 diabetes. Diabetic Medicine 24: 424-429, 2007.
Rachmiel M, Rota V, Atenafu E, Daneman D, Hamilton J. Final height in children with idiopathic growth hormone deficiency treated with a fixed dose of recombinant growth hormone. Horm Res 68: 236-243, 2007.
Wolfsdorf J, Craig ME, Daneman D, Dunger D, Edge J, Warren Lee W, Rosenbloom A, Sperling MA, Hanas R. Diabetic ketoacidosis. Pediatr Diabetes 8: 28-43, 2007.
Jefferies C, Solomon M, Perlman K, Sweezey N, Daneman D. Continuous glucose monitoring in adolescents with cystic fibrosis. J Pediatrics 147:396-8, 2005.
Lawrence SE, Cummings EA, Gaboury I, Daneman D. Population-based study of incidence and risk factors for cerebral edema in pediatric diabetic ketoacidosis. J Pediatr. 146:688-92, 2005.
Zlotnik Shaul R, Reid L, Essue B, Gibson J, Marzinotto V, Daneman D. Dissemination to research subjects: operationalizing investigator accountability. Accountability in Research 12:1-16, 2005
Glaab L, Brown R, Daneman D. School attendance in children with type 1 diabetes. Diabetic Medicine 22:421-426, 2005
Dunger DB , Sperling MA, Acerini CL, Bohn D, Daneman D, Danne TPA, Glaser NS, Hanas R, Hintz RL, Levitsky LL, Savage1 MO, Tasker RC, Wolfsdorf JI. ESPE/LWPES consensus statement on diabetic ketoacidosis in children and adolescents. Arch Dis Child. 2004 Feb; 89(2): 188-194; Pediatrics Feb;113(2):133-40, 2004.
Berger E, Sochett E, Peirone A, Parikh A, Daneman D. Cardiac and vascular function in adolescents and young adults with type 1 diabetes . Diabetes Technology and Therapeutics 6:129-35, 2004
Zdravkovic V, Daneman D, Hamilton J. Presentation and course of type 2 diabetes in youth in a multiethnic city. Diabetic Medicine 21:1144-8; 2004
Maharaj SI, Daneman D, Olmsted MP, Rodin GM. Metabolic control in adolescent girls with type 1 diabetes: Links to relationality and the female sense of self. Diabetes Care. 27:709-15, 2004
Hamilton J, Cummings B, Zdradkovic V, Finegood D, Daneman D. Metformin as an adjunct therapy in adolescents with type 1 diabetes and insulin resistance. Diabetes Care 26:138-43; 2003.
Curtis J, To T, Cummings E, Muirhead S, Daneman D. Recent trends in hospitalization for diabetic ketoacidosis (DKA) in Ontario children. Diabetes Care 25: 1591-1596, 2002.