Gabrielle deVeber, MD
The Hospital for Sick Children
Child Health Evaluative Sciences
University of Toronto
Department of Paediatrics
Dr. deVeber is Director of the Children's Stroke Program, a Senior Scientist in the Child Health Evaluation Sciences Program and a paediatric neurologist in the Division of Neurology at The Hospital for Sick Children (SickKids), Toronto, Canada. In addition, Dr. deVeber is a Professor of Paediatrics and a faculty member of The Institute of Medical Science at the University of Toronto. Her research focuses on stroke in newborns and children, defining the frequency, causes, treatments and outcomes of paediatric stroke. She initiated and directs several large multi-centre collaborative studies including the Canadian Paediatric Ischemic Stroke Registry and the International Paediatric Stroke Study (IPSS), a large international study of childhood stroke with over 4,494 enrolled children at over 201 enrolling centres spanning 45 countries in Asia, Europe and North and South America. The central organization and database reside at Sickkids. In 2009, National Institutes of Health (NIH) funded Dr. deVeber as dual principal investigator with H. Fullerton in the USA to study childhood infection and stroke within the IPSS in a seven-year study.
Clinical Care Activities
Children with stroke.
Areas of Specialty
Pediatric Thromboembolism Fellowship: Hamilton Civic Hospitals Research Center and McMaster University, Hamilton, 1995-07-01 - 1998-07-01
Masters in Health Sciences in Epidemiology, McMaster University, 2003
Clinical: Pediatric Neurorehabilitation
Spaulding Rehabilitation Hospital, Massachusetts General Hospital, 1990-07-01 - 1991-07-01
Main interests: The International Pediatric Stroke Study (IPSS); Toronto Children’s Stroke Project and Canadian Paediatric Ischemic Stroke Registry
The Children’s Stroke Project consists of a number of inter-related studies of childhood stroke caused by blood clots. The Canadian Paediatric Ischemic Stroke Registry has studied stroke in more than 8,000 infants and children at the 16 children’s hospitals in Canada. Stroke affects 1 in 2,300 births in Canada. Our studies in SickKids children have defined important causes for stroke including chicken pox and anticardiolipin antibodies, a clotting problem. We are also studying treatments and outcomes. Our Stroke Outcome Study has found disability in over 40 per cent, recurrent events in 20 per cent and seizures and headaches in another 25 per cent. We are hosting and actively developing multinational studies of treatments for childhood stroke with collaborators in the UK, USA and other countries in the IPSS and it's NINDS funded sub-studies.
- Risk Factors in paediatric stroke
- Safety and feasibility of anticoagulation in paediatric ischemic stroke
- Dose-finding and safety of tPA in childhood stroke
- Outcome and predictors in paediatric stroke
Further Research Activities
International clinical trials in childhood stroke.
- 2014 Child Neurology Society’s 2014 ‘Bernard Sachs Award’ (awarded annually to a physician/scientist of international status who has done leading neuroscience research in childhood neurological disorders and is an outstanding teacher and scholar)
- 2010 American Academy of Neurology Sydney Carter Award (awarded every two years to an outstanding paediatric neurologist)
- 2007 Canadian Pediatric Society Geoffrey C. Robinson Award (awarded every two years for research making major contributions to children's health)
- 2004 The Hospital for Sick Children David and Stacey Cynamon Clinical Scholarship in Paediatric Neuroscience
- 2001 - 2006 Heart and Stroke of Ontario: Stroke Investigator Award - Research Scholar
- July 1998 - July 2001 Stroke Investigator Award: Phase II, Junior Faculty
- July 1995 - 1998 Heart and Stroke Foundation of Ontario Stroke Investigator Award - Research Fellow
Sinclair A, Fox C, Ichord R, Almond C, Bernard T, Beslow LA, Chan AK, Cheung M, deVeber G, Dowling M, Friedman N, Giglia TM, Guilliams K Humpl T. Stroke in children with cardiac disease: Report from the International Pediatric Stroke Study. Pediatric Neurology 2015 Jan; 52(1):5-15
Chen L, Yau I, deVeber G, Dirks P, Armstrong D, Krings T. Evolution of a chronic dissecting aneurysm on magnetic resonance imaging in a pediatric patient. Journal of Neurosurgery – Pediatrics 2014 Dec: 5: 1-5
Rafay M, Armstrong D, Dirks P, MacGregor DL, deVeber G. Patterns of cerebral ischemia in children with moyamoya. Pediatric Neurology 2015 Jan; 52(1): 65-72.
Plumb P, Seiber E, Dowling M, Lee JE, Bernard TJ, deVeber G, Ichord R, Bastian R, Lo WD. Out of pocket costs for pediatric stroke care. Pediatric Neurology 2015 Jan; 52(1): 73-76.
Wintermark M, Hills NK, deVeber GA, Barkovich AJ, Elkind MS, Sear K, Zhu G, Leiva-Salinas C, Hou Q, Dowling MM, Bernard TJ, Friedman NR, Ichord RN, Fullerton HJ; the VIPS Investigators. Arteriopathy Diagnosis in Childhood Arterial Ischemic Stroke: Results of the Vascular Effects of Infection in Pediatric Stroke Study. Stroke. 2014 Dec: 45(12): 3597-3605
Fuentes A, Deotto A, Desrocher M, deVeber G, Westmacott R. Determinants of cognitive outcomes of perinatal and childhood stroke: A review. Child Neuropsychol. 2014 Oct 30:1-38. [Epub ahead of print]
Sultan S, Schupf N, Dowling M, deVeber G, Kirton A, Elkind MS; IPSS Investigators. Predictors of cholesterol and lipoprotein(a) testing in children with arterial ischemic stroke. J Stroke Cerebrovasc Dis. 2014 Oct;23(9):2405-13.
Xavier F, Komvilaisak P, Williams S, Kulkarni AV, deVeber G, Moharir MD. Anticoagulant therapy in head injury-associated cerebral sinovenous thrombosis in children. Pediatr Blood Cancer. 2014 NOV 61(11):2037-42.
Boelman C, Shroff M, Yau I, Bjornson B, Richardson S, deVeber G. Antithrombotic therapy for secondary stroke prevention in bacterial meningitis in children. Pediatrics 2014 Oct;165(4):799-806.
Bernard TJ, Rivkin MJ, Scholz K, deVeber G, Kirton A, Gill JC, Chan AK, Hovinga CA, Ichord RN, Grotta JC, Jordan LC, Benedict S, Friedman NR, Dowling MM, Elbers J, Torres M, Sultan S, Cummings DD, Grabowski EF, McMillan HJ, Beslow LA, Amlie-Lefond C. Emergence of the primary pediatric stroke center: impact of the thrombolysis in pediatric stroke trial. Stroke 2014 Jul; 45(7):2018-23.
Kassbaum NJ, et al. Global, regional and national levels and causes of maternal mortality during 1990-2013l a systematic analysis for the Global Burden of Disease Study 2013. The Lancet Neurology 2014 Sep 13;384(9947):980-1004.
Sultan SM, Schupf N, Dowling MM, deVeber G, Kirton A, Elkind MS. Review of lipid and lipoprotein(a) abnormalities in childhood arterial ischemic stroke. Int J Stroke. 2014 Jan;9(1):79-87.
Mah S, deVeber G, Wei XC, Liapounova N, Kirton A. Cerebellar atrophy in childhood arterial ischemic stroke: Acute diffusion MRI biomarkers. Stroke. 2013 Sep;44(9):2468-74.
Kirton A, Crone M, Benseler S, Mineyko A, Armstrong D, Wade A, Sebire G, Crous-Tsanaclis AM, deVeber G. Fibromuscular dysplasia and childhood stroke. Brain 2013 Jun;136(Pt 6):1846-56.
Tan M, Miller E, Shroff MM, deVeber G, Kirton A. Alleviation of neonatal sinovenous compression to enhance cerebral venous blood flow. Journal of Child Neurology 2013 May; 28(5)583-588.
Elbers J, deVeber G, Pontigon AM, Moharir M. Long-term outcomes of pediatric ischemic stroke in adulthood. Journal of Child Neurology 2013 April 15. Epub ahead of print. PMID: 23589374
Lagman-Bartolome M, Askalan R, Moharir M, MacGregor D, Yau I, Pontigon AM, deVeber G. Basilar Artery Strokes in Children: Good Outcomes with Conservative Medical Treatment; Developmental Medicine and Child Neurology. 2013 May; 55(5):434-439.
Jones KC, Hawkins C, Armstrong D, deVeber G, MacGregor D, Moharir M, Askalan R. Association between radiographic Wallerian degeneration and neuropatholoigcal changes post childhood stroke. Developmental Medicine and Child Neurology 2013. Feb; 55(2);173-177.
Dowling MM, Hynan LS, Lo W, Licht DJ, McClure C, Yager JY, Dlamini N, Kirkham FJ, deVeber G, Pavlakis S; for the International Paediatric Stroke Study Group. International Paediatric Stroke Study: stroke associated with cardiac disorders. International Journal of Stroke. 2013 Oct;8 Suppl A100:39-4.
Drake JM, Singhal A, Kulkarni A, deVeber G, Cochrane DD; Canadian Pediatric Neurosurgery Study Group. Consensus definitions of complications for accurate recording and comparisons of surgical outcomes in pediatric neurosurgery. Journal of Neurosurgery, Pediatrics 2012 Aug; 10(2):89-95.
Rodan L, McCrindle BW, Manlihot C, MacGregor DL, Askalan R, Moharir M, deVeber G. Stroke recurrence in children with congenital heart disease. Annals of Neurology 2012 Jul; 72(1):103-111.
Coutinho JM, de Bruijn SF, deVeber G, Stam J. Anticoagulation for cerebral venous sinus thrombosis. Stroke. 2012 Apr; 43(4):e41-e42.
Kitchen L, Westmacott R, Friefeld S, MacGregor D, Curtis R, Allen A, Yau I, Askalan R, Moharir M, Domi T, deVeber G. The Pediatric Stroke Outcome Measure: A Validation and Reliability Study. Stroke 2012 Apr 3. [Epub ahead of print] SRI
Schechter T, Finkelstein Y, Ali M, Kahr W, Williams S, Chan AK, deVeber G, Brandão LR. Unfractionated heparin dosing in young infants: Clinical outcomes in a cohort monitored with anti-factor Xa levels. J Thromb Haemost. 2012 Mar; 10(3): 368-374.
Williams TS, Westmacott R, Dlamini N, Granite L, Dirks P, Askalan R, MacGregor D, Moharir M, deVeber G. Intellectual ability and executive function in pediatric moyamoya vasculopathy. Developmental Medicine and Child Neurology 2012 Jan; 54(1):30-37 SRI
Schechter T, Kirton A, Laughlin S, Pontigon AM, Finkelsteing Y, MacGregor D, Chan A, deVeber G, Brandao L. Safety of anticoagulants in children with arterial ischemic stroke. Blood. 2012 Jan 26;119(4):949-956.
Lo W, Ichord R, Templeton J, Halperin A, Smith S, Licht DJ, Moharir M, Askalan R, deVeber G for the International Pediatric Stroke Study. Validation of the stroke recurrence and recovery questionnaire (RRQ): in a large prospective cohort with pediatric ischemic stroke. Neurology December 2011. In press
Dlamini N, Freeman JL, Mackay MT, Hawkins C, Shroff M, Fullerton HJ, deVeber G. Intracranial dissection mimicking transient cerebral arteriopathy in childhood arterial ischemic stroke. Journal of Child Neurology 2011 Sep;26(9):1203-1206. SRI
Friefeld SJ, Westmacott R, MacGregor D, deVeber G. Predictors of quality of life in pediatric survivors of arterial ischemic stroke and cerebral sinovenous thrombosis. Journal of Child Neurology 2011 Sep;26(9):1186-1192.
Fullerton HJ, Elkind MS, Barkovich AJ, Glaser C, Glidden D, Hills NK, Leiva-Salinas C, Wintermark M, deVeber G. The Vascular Effects of Infection in Pediatric Stroke (VIPS) Study. Journal of Child Neurology 2011 Sep;26(9):1101-1110.
Moharir MD, Shroff M, Pontigon AM, Askalan R, Yau I, Macgregor D, deVeber G. A prospective outcome study of neonatal cerebral sinovenous thrombosis. Journal of Child Neurology 2011 Sep;26(9):1137-1144.
Saposnik G, Baringarrementaria F, Brown RD Jr, Bushnell CD, Cucchiara B, Cushman M, deVeber G, Ferro JM, Tsai FY on behalf of the American Heart Association Stroke Council and the Council on Epidemiology and Prevention. Diagnosis and management of cerebral venous thrombosis: A statement for healthcare professionals from The American Heart Association/American Stroke Association. Stroke 2011 Apr;42(4):1158-1192.
Kirton A, Shroff M, Pontigon AM, deVeber G. Risk factors and presentations of periventricular venous infarction vs arterial presumed perinatal ischemic stroke. Archives of Neurolology 2010 Jul; 67(7):842-848.
Moharir MD, Shroff M, Stephens D, Pontigon AM, Chan A, MacGregor D, Mikulis D, Adams M, deVeber G. Anticoagulants in pediatric cerebral sinovenous thrombosis: a safety and outcome study. Annals of Neurology 2010 May; 67(5):590-599. SRI C R
deVeber G. Delays in the timely diagnosis of stroke in children. Nature Neurology 2010 Feb; 6:64-66.
Goldenberg N, Bernard T, Fullerton H, Gordon A, deVeber G; for the International Pediatric Stroke Study Group. Antithrombotic treatments, outcomes, and prognostic factors in acute childhood-onset arterial ischemic stroke: a multicentre, observational, cohort study. Lancet Neurology 2009 Dec; 8(12):1120-1127. SRI CR
Govaert P, Ramenghi L, Taal R, de Vries L, deVeber G. Diagnosis of perinatal stroke I: definitions, differential diagnosis and registration. Acta Paediatrica 2009 Oct; 98(10):1556-1567. SRI C
Westmacott R, Askalan R, MacGregor DL, Anderson P, deVeber G. Cognitive outcome following unilateral stroke in childhood: Effects of age at stroke and lesion location. Developmental Medicine and Child Neurology 2009 Aug; 52(4):386-393. SRI CR
Westmacott R, MacGregor DL, Askalan R, deVeber G. Late emergence of cognitive deficits following unilateral neonatal stroke. Stroke 2009 Jun; 40(6):2012-2019. SRI CR
deVeber G. Pediatric Stroke. Who should be treated? Hämostaseologie 2009 Jan; 29(1):88-90. PA CE
Golomb M, Fullerton H, Nowak-Gottl U, deVeber G for the International Pediatric Stroke Study Group. Male predominance in childhood ischemic stroke: Findings from the International Pediatric Stroke Study. Stroke 2009 Jan; 40(1):52-57. SRI R
Domi T, Edgell DS, McCrindle BW, Williams WG, Chan AK, MacGregor D, Kirton A, deVeber G. Frequency, predictors, and neurological outcome of vaso-occlusive strokes associated with cardiac surgery in children. Pediatrics 2008 Dec; 122(6):1292-1298. SRI R
Lindsay P, Bayley M, Hellings C, Hill M, Woodbury E, Phillips S on behalf of the Canadian Stroke Strategy (a joint initiative of the Canadian Stroke Network and the Heart and Stroke Foundation of Canada). Canadian best practice recommendations for stroke care (Updated 2008). Canadian Medical Association Journal 2008 Dec; 179(12):S1-S25. C C
deVeber G, Kirkham F. Guidelines for the treatment and prevention of stroke in children. The Lancet Neurology 2008 Nov; 7(11):983-985. PA C
Rafay M, Pontigon A, Chiang J, Adams M, Jarvis A, Silver F, deVeber G. Delay to diagnosis in acute pediatric arterial ischemic stroke. Stroke 2009 Jan; 40(1):58-64. SRI CR
Roach ES, Golomb M, Adams R, Biller J, Daniels S, deVeber G, Ferriero D, Jones B, Kirkham FJ, Scott RM, Smith ER. Guidelines on management of stroke in infants and children: A scientific statement for healthcare professionals from a special writing group of the American Heart Association Stroke Council and the Council on Cardiovascular Disease in the Young. Stroke 2008 Sept; 39(9):2644-2691. C C
Kirton A, Chen R, Friefeld S, Gunraj C, Pontigon A, deVeber G. Contralesional repetitive transcranial magnetic stimulation for chronic hemiparesis in subcortical pediatric stroke: a randomised trial. Lancet Neurology 2008 Jun; 7(6): 507-513. SRI R
Kirton A, Shroff M, Visvanathan T, deVeber G. Quantified corticospinal tract diffusion restriction predicts neonatal stroke outcome. Stroke 2007; 38:974-980. SRI R
Kirton A, deVeber G. Ischemic stroke complicating pediatric cardiac disease. Nature Clinical Practice Cardiovascular Medicine 2007; 4(3):163-166. CPA CE
Maguire JL, deVeber G, Parkin P. Association between iron-deficiency anemia and stroke in young children. Pediatrics 2007 Nov; 120(5):1053-1057. CPA CR
McLinden A, Baird AD, Westmacott R, Anderson PE, deVeber G. Early cognitive outcome after neonatal stroke. Journal of Child Neurology 2007 Sept; 22(9):1111-1116. SRI R
Braun KP, Rafay MF, Uiterwaal CS, Pontigon AM, deVeber G. Mode of onset predicts etiological diagnosis of arterial ischemic stroke in children. Stroke 2007 Feb; 38(2):298-302. CPA CR
Braun KP, Kappelle LJ, Kirkham FJ, deVeber G. Diagnostic pitfalls in paediatric ischemic stroke. Developmental Medicine and Child Neurology 2006; 48(12):985-990. CPA CR
Massicotte MP, Sofronas M, deVeber G. Difficulties in performing clinical trials of antithrombotic therapy in neonates and children. Thrombosis Research 2006; 118(1):153-63. CPA R
Barnes C, deVeber G. Prothrombotic abnormalities in childhood ischemic stroke. Thrombosis Research 2006; 118(1):67-74. SRI CE
Pavlakis S, Hirtz D, deVeber G. Pediatric Stroke: Opportunities and challenges in planning clinical trials. Pediatric Neurology 2006 Jun; 34(6):433-435. CPA CR
Rafay M, Smith S, Dirks P, Armstrong D, deVeber G. Hemorrhage predisposing to cerebral infarction in children with moyamoya. Pediatric Neurology 2006 May; 34(5):400-404. SRI CR
Benseler S, Silverman E, Aviv R, Schneider R, Armstrong D, Tyrell P, deVeber G. Primary CNS vasculitis in children. Arthritis and Rheumatism 2006 Apr; 54(4):1291-1297. SRI R
Lynch JK, Pavlakis S, deVeber G. Treatment and prevention of cerebrovascular disorders in children. Current Treatment Options in Neurology 2005 Nov; 7(6):469-480. SRI CE
Hetherington R,Tuff L, Anderson P, Miles B, deVeber G. Short-term intellectual outcome after arterial ischemic stroke and sinovenous thrombosis in childhood and infancy. Journal of Child Neurology 2005 Jul; 20(7):553-559. SRI R
deVeber G. In pursuit of evidence-based treatments for paediatric stroke: the United Kingdom and Chest guidelines. Lancet Neurology 2005 Jul; 4(7):432-436. PA CE
Lanthier S, Armstrong D, Domi T, deVeber G. Post-varicella arteriopathy of childhood: natural history of vascular stenosis. Neurology 2005 Feb; 64(4):660-663. SRI R
Sebire G, Fullerton H, Riou E, deVeber G. Towards the definition of cerebral arteriopathies of childhood. Current Opinion in Pediatrics 2004 Dec; 16(6):617-622. SRI C
Chow G, Koirala B, Armstrong D, McCrindle BW, Bohn D, Edgell D, Coles J, deVeber G. Predictors of mortality and neurological morbidity in children undergoing extracorporeal life support for cardiac disease. European Journal of Cardio-Thoracic Surgery 2004 Jul; 26(1):38-43. SRI R (Published as de Veber)
Hutchison JS, Ichord R, Guerguerian AM, deVeber G. Cerebrovascular disorders. In special issue “Critical Care Neurology”, Seminars in Pediatric Neurology 2004 Jun; 11(2):139-146. SRI C
Friefeld S, Yeboah O, Jones J, deVeber G. Health-related quality of life and its relationship to neurological outcome in child survivors of stroke. CNS Spectrums 2004; Jun 9(6):465-475. SRI R
Lanthier S, Kirkham F, Mitchell LG, Laxer RM, Atenafu EG, Male C, Prengler M, Domi T, Chan A, Liesner R, deVeber G. Increased anticardiolipin antibody IgG titers do not predict recurrent stroke or TIA in children. Neurology 2004 Jan; 62(2):194-200. SRI R
Shroff M, deVeber G. Sinovenous thrombosis in children. Neuroimaging Clinics of North America 2003, 13:115-138. PA R
Golomb MR, deVeber G, MacGregor DL, Domi T, Whyte H, Stephens D, Dick P. Independent walking after neonatal arterial ischemic stroke and sinovenous thrombosis. Journal of Child Neurology 2003 Aug; 18(8):530-536. SRI R
Golomb M, MacGregor D, Domi T, Armstrong D, McCrindle B, Mayank S, and deVeber G. Presumed pre-or perinatal arterial ischemic stroke: risk factors and outcomes. Annals of Neurology 2001; 50(2):163 - 168
deVeber G, Andrew M, Adams C et al for The Canadian Pediatric Ischemic Stroke Study Group. Cerebral sinovenous thrombosis in childhood. NEJM 2001: Aug 9; 345:417-423
Askalan R, Laughlin S, Mayank S, Chan A, MacGregor D, Curtis R, Meaney B, deVeber G. Chicken pox and stroke in childhood: A study of frequency and causation. Stroke 2001; 32:1257-1262
Lanthier S, Lortie A, Michaud J, Laxer R, Jay V, deVeber G. Isolated angiitis of the CNS in children. Neurology 2001; 56:837-842
deVeber G, MacGregor D, Curtis R and Mayank S. Neurological outcome in survivors of childhood arterial ischemic stroke and sinovenous thrombosis. J Child Neurol 2000;15:316-324
Lanthier S, Carmant L, David M, Larbrisseau A, de Veber G. Stroke in children: the coexistence of multiple risk factors predicts poor outcome. Neurology 2000; 54(2):371-8