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About Sickkids
About SickKids

Lynda Ellis, RN

Brief Biography

Lynda is a graduate of the Victoria General Hospital Nursing School, Halifax, Nova Scotia. She has spent her entire career at The Hospital for Sick Children, as a staff nurse, team leader, unit manager and then on to a 20 year career as a clinical research nurse coordinator. Most of her research activities have been focused on cystic fibrosis and Shwachman Diamond syndrome with the focus mainly on genotype-phenotype correlations. Many of the projects have involved international collaborations which has provided opportunities to travel to meetings and to work with nurses and physicians from many countries.

Clinical Care Activities

  • Member of Medical Scientific Board for Shwachman Diamond Syndrome (SDS) Support Foundation, USA 2004 - present

  • Planning Committee SDS Camp 2006
    Teaching: classes on nutrition and use of pancreatic enzyme for patients and families at Shwachman Diamond syndrome family camps (held every 2 years)
    Teaching: Technique for nasal potential difference testing Verona, Italy 2006

  • Orientation and Professional Development for Clinical Research Nurse Coordinators
    - chair of research nurses group 1990 -2002
    - member of peer review team 2000-2005
    - member of Nursing Retreat planning committee 2004
    - member of orientation committee for CRNC 2006
    Chair of Research Institute Citizenship Award Committee 2001, 2002, 2004

Research Interests

Ethics in research (especially in genetic studies), better diagnostic tools for cystic fibrosis and Shwachman Diamond Syndrome.

Research Activities

Cystic Fibrosis:
Nutrition and Genotype Phenotype Relationships
Establishing Diagnostic Criteria for CF and Related Disorders
Chloride Channel function - Nasal Potential difference Testing

Shwachman Diamond Syndrome:
Genotype Phenotype Relationships
Protein Expression in SBDS Gene
Establishing Canadian and International Patient Database

Achievements

  • Citizenship Award Research Institute 1999

  • Grace Evelyn Simpson Reeves Award for Nursing Research 2005

Publications

Schilbi, S, Corey M, Gaskin, K, Ellis, L, Durie, P. (2006) Towards the ideal quantitative pancreaticfunction test: analysis of test variables that influence validity. Clin Gastroenterology and Hepatology;4:90-97

Kalnins D, Ellis, L, Corey M, Pencharz P, Stewart C, Durie PR (2006) Enteric coated pancreatic enzymes with bicarbonate is equal to standard enteric coated enzyme in treating malabsorption in cystic fibrosis. J Pediatr Gastroenterol and Nutri: Vol 42:256-261

Cantin, AM, Hanrahan JW, Bilodeau G, Ellis, L, Liao J, Zielenski J, Durie P. (2006) Cystic Fibrosis Transmembrane Conductance regulator function is suppressed in cigarette smokers. Am J Respir Crit Care;173(10):1139-44.

Kalnins D, Corey M, Ellis, L, Durie PR, Pencharz PB. (2005) Combining unprotected pancreatic enzymes with PH- sensitive enteric-coated microspheres does not improve nutrient digestion in patients with cystic fibrosis. J Pediatr 146 (4):487-91

Bishop MD , Freedman SD, Zielenski J, Ahmed N, Dupuis A, Martin S, Ellis, L, Shea J, Hoper I, Steele L, Corey M, Kortan P, Haber G, Ross C, Tsountzouris, Ray PN, Tsui L-C, Durie, PR. (2005)The cystic fibrosis transmembrane conductance regulator gene and ion channel function in patients with idiopathic pancreatitis Hum Genet 118:372-381

Kalnins D, Corey M, Ellis, L, Pencharz PB, Tullis E, Durie PR. (2005) Failure of conventional strategies to improve nutritional status in malnourished adolescents and adults with cystic fibrosis. J Pediatr 147(3): 399-401

Giljam M, Ellis, L, Coret M, Zielenski J, Durie, P, Tullis, E. (2004) Clinical manifestations of cystic fibrosis among patients diagnosed in adulthood Chest 125(4):1215-1224

Makitie O, Ellis, L, Durie PR, Morrison JA, Sochett EB, Rommens JM, Cole WG. (2004) Skeletal phenotype in patients with Shwachman-Diamond syndrome and mutations in SBDS. Clinical Genetics 65:101-112

Gelrud A, Sheth S, Banerjee S, Weed D, Shea J, Chuttani R, Howell DA, Telford JJ, Carr-Locke DL, Regan MM, Ellis, L, Durie PR, Freedman SD. (2004) Analysis of cystic fibrosis gene product (CFTR) function in patients with pancreas divisum and recurrent acute pancreatitis. Am. J.Gastroenterol 99(8):1557-62,

Boocock, G., Morrison, J., Popovic, M., Richards, N., Ellis, L, Durie, P., Rommens, J. (2003) Mutations in SBDS are associated with Shwachman Diamond syndrome. Nature Genetics;33(1):97-101

Ahmed, N., Corey, M., Forstner, G., Tsui, L-C., Ellis, L, Tullis, E, Durie, P. (2003) Molecular consequences of cystic fibrosis transmembrane regulator (CFTR) gene mutations in the exocrine pancreas. Gut;52:1159-1164

Ip,W., Dupuis, A., Ellis, L, Beharry,S., Morrison J., Stormon, M., Corey, M., Rommens, J., Durie, P. (2002) Serum pancreatic enzymes define the pancreatic phenotype in patients with Shwachman Diamond syndrome. J.Pediatr. Number 2, Vol. 141, 259-265

Beharry, S., Ellis, L, Corey, M., Marcon, M., Durie, P. (2002) How useful is fecal elastase 1 as a marker of exocrine pancreatic disease? J. Pediatr. Vol. 141, Number 1 84-90

Goobie, S, Popovic, M., Morrison, J., Ellis, L, Durie,P., Rommens, J. et al (2001) Shwachman-Diamond Syndrome with exocrine pancreatic dysfunction and bone marrow failure maps to the centromeric region of chromosome 7. Am. J. Hum. Genet:68:1048-1054

Ginzberg H, Shin, J., Ellis, L, Goobie, S., Morrison, J, Corey, M., Durie, P., Rommens, J. (2000) Segregation Analysis in Shwachman-Diamond Syndrome: Evidence for Recessive Inheritance. Am. J.Hum Genet.66:1413-1416

Goobie,S., Morrison, J., Ginzberg, Ellis, L, Corey, M., Masuno, K., Imaizumi, K., Kuroki, Y, Fujiwara, T., Morgan, K, Durie,P., Rommens, J. (1999) Exclusion of linkage of Shwachman -Diamond Syndrome to chromosome regions 6q and 12q implicated by a de nova translocation .Am J Med Genet 85:171-174

Ginzberg H, Shin J, Ellis, L, Morrison J, Ip W, Dror Y, Freedman M, Heitlinger LA, Belt MA, Corey M, Rommens JM, Durie PR. (1999) Shwachman syndrome: Phenotypic manifestations of sibling sets and isolated cases in a large patient cohort are similar. J. Pediatr. Vol. 135:81-88

Ellis, L, Kalnins, D, Corey, M., Brennan, J., Pencharz P., Durie, P. (1998) Do infants with cystic fibrosis need an extensively hydrolyzed formula? A prospective, randomized study. Journal of Pediatrics 132:2, 270-276

Wilson, D., Ellis, L, Zielenski, J., Corey, M., Ip, W., Tsui, L-C., Tullis, E., Knowles, M., Durie, P.R. (1998) Uncertainty in the diagnosis of cystic fibrosis: Possible role for in vivo nasal potential difference measurements. Journal of Pediatrics 132:4 596-599

Durie, P, Kalnins, D, Ellis, L, (1998) Uses and abuses of enzyme therapy in cystic fibrosis. Journal of the Royal Society of Medicine Supplement No 34, Vol 91,2-13

Otulakowski, G., Flueckiger-Staub, S., Ellis, L, Ramlall, K., Staub, O., Smith, D., Durie, P., O'Brodovich, H. (1998) Relationship between Ý ,B, and y human amiloride-sensitive epitheleal Na+ channel mRNA levels and nasal epithelial potential difference in healthy men. Am J Respir Crit Care Med Vol 158, 1213-1220

Furuya, K, Durie P. Roberts, E, Soldin S, Vergee, Z, Giesbrecht, E Yung-Jato L. Ellis, L, (1995) :Glycine Conjugation of Para-Aminobenzoic Acid (PABA): A Quantitative test of Liver Function. Clinical Biochemistry Vol 28 No5, pp531-540

Durie, P., Yung-Sato, L.Y., Soldin, S.J., Verjee, Z., Ellis, L, (1992) The bentiromide test using liquid-chromatographic measurements of p-aminobenzoic acid and its metabolites for diagnosing pancreatic insufficiency in childhood. J. Pediatr. 121:413-416

Mack, D.R., Flick, J.A., Durie, P.R., Rosenstein, B.J., Ellis, L.E., Perman, J.A., (1992) Correlation of intestinal lactulose permeability with exocrine pancreatic dysfunction. J. Pediatr. 120:696-701

Laufer, D., Cleghorn, G., Ellis, L, Koren G., Forstner, G.G., Durie, P.R. (1991) The Bentiromide test using plasma PABA for diagnosing pancreatic insufficiency in young children. Gastroenterology 101:207-213

Koletzko. S, Corey, M., Ellis, L, Spino, M., Durie, P.R.,: (1990) The effects of Cisapride in the treatment of patients with cystic fibrosis and the distal intestinal obstruction syndrome. J. Pediatr. 117:815- 822

Drumm, B., Stringer, D.A., Ellis, L.E., Rhoads, M.,Sherman, P., Durie, P.R (1988): Peptic ulcer disease in childhood: etiology, clinical findings and clinical course, Pediatrics 82:410-414

Durie, P.R., Gaskin, K.J., Weizman, Z., Koppleman, H.R., Ellis, L, Forstner, G.G., and Largman, C.: (1985) Elevated serum immunoreactive pancreatic cationic trypsinogen in malnutrition: evidence of pancreatic damage. J. Pediart.106:233-38

Abstracts and Poster Presentations
Involved in total of 85 ( 20 as first author)