Facebook Pixel Code
About Sickkids
About SickKids

Brian Feldman, MD, M.Sc., FRCPC

The Hospital for Sick Children
Division Head
Rheumatology

Research Institute
Senior Scientist
Child Health Evaluative Sciences

University of Toronto
Professor
Department of Pediatrics & Medicine

Professor
Health Policy Management & Evaluation

Professor
Dalla Lana School of Public Health


Phone: 416-813-5828
Fax: 416-813-4989
Email: brian.feldman@sickkids.ca

Brief Biography

Dr. Brian Feldman is Professor of Pediatrics, Medicine, Health Policy Management & Evaluation, and the Dalla Lana School of Public Health at the University of Toronto. He is Division Head of Rheumatology at The Hospital for Sick Children. Dr. Feldman graduated from the University of Western Ontario (MD, 1985) and he did further graduate training in clinical epidemiology at the University of Toronto (MSc, 1994). He interned at the Mount Sinai Hospital in Toronto and went on to do a core pediatric residency at the Children’s Hospital of Eastern Ontario. Dr. Feldman returned to Toronto to be an associate chief resident at The Hospital for Sick Children. He stayed on there to complete a fellowship in pediatric rheumatology.

Dr. Feldman’s main focus has been in clinical research in the field of childhood rheumatic disease. Recognizing the challenges involved in the study of rare disease Dr. Feldman has worked to improve the tools available to assist in this research. He has worked at developing and refining outcome measurement tools for use in clinical trials and in outcome studies. He has developed innovative methodologies for the study of new therapies (e.g. the Randomized Placebo Phase Design) and refined and tested powerful existing methods (e.g. Bayesian meta-analysis of n-of-1 randomized trials). Dr. Feldman has made contributions to the understanding of the prognosis and treatment of juvenile dermatomyositis, the cost-effective prevention of arthropathy in severe hemophilia, the course and outcome of systemic-onset juvenile idiopathic arthritis and juvenile SLE, and the role of fitness and exercise in childhood chronic diseases including arthritis and fibromyalgia.

Dr. Feldman’s research, by its nature, is collaborative. As such he is a member of the Pediatric Rheumatology Collaborative Study Group, the Canadian Alliance of Pediatric Rheumatology Investigators, the International Myositis Assessment Criteria study group, and other collaborative organizations. He was one of the founding members of the Childhood Arthritis and Rheumatology Research Alliance (CARRA), and was the head of the protocol evaluation subcommittee and chair of the Juvenile Dermatomyositis subcommittee.

Research Interests

  • Clinical trial design
  • Paediatric rheumatic diseases
  • Juvenile dermatomyositis

Research Activities

  • Clinical trials in childhood arthritis and cost-effectiveness of preventative therapy in hemophilia
  • Developing methodologies and measurement tools that allow for valid clinical treatment trials in subjects with rare diseases

External Funding

Senior Investigator's Name Appears in Bold

Effects of Creatine Supplementation on Muscle Pathophysiology in Children with Dermatomyositis. Stephens S, Feldman BM, Wells GD, Tien I, Schulze A. Rare Disease Foundation and the BC Children’s Hospital Foundation (BCCNF) (2012-2013) PI

Fluid Accumulation in Pediatric Postthrombotic Syndrome. Brandao LR, Feldman BM, Stinson J, Kiss A, Avila ML. PSI Health Research Grant (2013-2014) CoI

Servicing Ontario’s Children and Youth with Arthritis. Feldman B, Levy D, Laxer R, Schneider R, Roth J, Berard R, Soon G, Blanchette N, Whitney-Mahone K, Murray S, O’Brien C, Graham N. The Arthritis Society (10/2013-09/2014) PI

An open dose escalating factor VIII prophylaxis study assessing the safety efficacy and cost-effectiveness in young patients with severe haemophilia A (Canadian haemophilia primary prophylaxis observational extension study and pharmacokinetic substudy). Blanchette V, Feldman B.  Bayer Canada (2013-2015) Co PI

The Hemophilia Joint Health Score v2.1 Validation in Adult Patients Study: (HJHS - VAPS) A multi-centre international study.   St-Louis J, Feldman BM: International Prophylaxis Study Group (12/2014 – 06/2016)  Co PI

The effect of creatine supplementation on muscle function in childhood myositis. Feldman BM, Stephens S, Wells GD, Tien I, Schulze A, Schneiderman J. The Myositis Association (2014-2016)  PI

Jointly Managing JIA Online: An Internet-based Psycho-educational Game for children with Juvenile Idiopathic Arthritis (JIA) and their Parents.  Stinson JN, Berard R, Feldman B, Mcgrath P, Tucker L, Campillo S, Huber A, Shiff N, Victor J, Dancey P, Johnson N, Spiegel L, Duffy C, Luca N, Tse S.  Canadian Institutes of Health Research (10/2014 – 03/2017)  CoI

iCanCope with Pain: Usability and Feasibility Testing of a Smartphone Application to Manage Pain in Youth with Arthritis. Stinson J, Laxer RM (Co-PI), Feldman B, Luca N, Spiegel L, Lalloo C, Connelly M, Menna-Dack D. The Arthritis Society.  (10/1/2014 - 9/30/2017)  CoI

Multi-site Randomized Clinical Trial of FIT Teens for Juvenile Fibromyalgia.  Kashikar-Zuck S, Stinson J, Feldman B, Tse S calendar months.  NIH/NAIMS. (7/1/16-6/30/21)

Achievements

  • Eugenie Stuart Award for Best Instructor.  Faculty of Medicine Department of Health Policy, Management & Evaluation.  University of Toronto.  2011
  • Department of Paediatrics Physician Research Award for Scientific Accomplishment.  University of Toronto.  2007
  • Arthritis Foundation (Alabama Chapter) Outstanding Speaker Award.  2007
  • Canada Research Chair in Childhood Arthritis Tier II, 2007-2012.  2007
  • University of Toronto Department of Paediatric Award for Scientific Merit - 2007
  • James C. Fallis Teaching Award, Runner-up for presentation at PEM Fellows' Rounds.  2004
  • Henry Kunkel Young Investigator Award, American College of Rheumatology.  2004
  • Canada Research Chair in Childhood Arthritis, Tier II, 2002 – 2007. 2002
  • Post-Graduate Excellence in Teaching, PERLS Lecture Series.  1998
  • Ontario Ministry of Health Career Scientist 1995-2002.  1995
  • Clinical Epidemiology Research Award.  University of Toronto.  1994
  • Philip Rosen Research Award. Canadian Rheumatology Association.  1993
  • Children's Hospital of Eastern Ontario - Core - Resident - Resident Research Award - 3rd Year.  1989
  • University of Western Ontario John C. Rathburn Memorial Prize for highest standing in Pediatrics during the Clinical Clerkship.  1985
  • University of Western Ontario Dean's Honour List.  1985
  • University of Western Ontario Benjamin Weidenbaum and Cecelia Rotstein Scholarship for the second highest standing in the Clinical Clerkship.  1985
  • University of Western Ontario Tuition Scholarship. 1979-1981.  1979

Publications

PA-denotes Principal Author; SRI-Senior Responsible Investigator; CPA-Co-Principal Author; C-Collaborator.

Huber AM, Kim S, Reed AM, Carrasco R, Feldman BM, Hong SD, Kahn P, Rahimi H, Robinson AB, Vehe RK, Weiss JE, Spencer C;  Juvenile Dermatomyositis Research Committee of the Childhood Arthritis and Rheumatology Research Alliance. Childhood arthritis and rheumatology research alliance  consensus clinical treatment plans for juvenile dermatomyositis with persistent skin rash. The Journal of Rheumatology.  2017 Jan: 44 (1): 110-116.  C

Avila ML, Brandao LR, Williams S, Montoya MI, Stinson J, Kiss A: Development of CAPTSure - a new index for the assessment of pediatric postthrombotic syndrome. Journal of Thrombosis and Haemostasis: JTH. 2016 Dec: 14 (12): 2376-2385.  SRA

Stephens SL, Tremblay MS, Faulkner G, Beyene J, Nguyen TH, Koohsari S, Limenis E, Feldman BM: Validity of the stage of exercise scale in children with rheumatologic conditions.  Journal of Rheumatology. 2016 Dec: 43(12): 2189-2198.  C

Abrahamyan L, Feldman BM, Tomlinson G, Faughnan ME, Johnson SR, Diamond IR, Gupta S:  Alternative designs for clinical trials in rare diseases.  American Journal of Medical Genetics Part C (Seminars in Medical Genetics).   2016 Dec: 172(4): 313-331.  C

Luca NJ, Burnett HF, Ungar WJ, Moretti M, Beukelman T, Feldman BM, Schwartz G, Bayoumi AM: Cost-effectiveness analysis of early biologic treatment in polyarticular juvenile idiopathic arthritis.  Arthritis Care and Research.  2016 Dec: 68 (12) 1803-1811.  C

Yeung RS, Albani S, Feldman BM, Mellins E, Prakken B, Wedderburn LR: Enhancing translational research in paediatric rheumatology through standardization. Nature Reviews: Rheumatology. 2016 Nov: 12(11): 684-90.  C

Poonnoose PM, Hilliard P, Doria AS, Keshava SN, Gibikote S, Kavitha ML, Feldman BM, Blanchette V, Srivastava A:  Correlating clinical and radiological assessment of joints in haemophilia: results of a cross sectional study.  Haemophilia. 2016 Nov: 22(6): 925-933.  C

Peters S, Ota S, Bolous E, Reich E, Chait S, Feldman BM: The Responsiveness of the Modified Childhood Health Assessment Questionnaire. Journal of Rheumatology. 2016 Oct: 43 (10): 1904-8.  SRA

Jamal AN, Feldman BM, Pullenayegum E: The use of neck support pillows and postural exercises in the management of chronic neck pain. Journal of Rheumatology. 2016 Oct: 43 (10): 1871-3.  SRA

Fischer K, Poonnoose P, Dunn AL, Babyn P, Manco-Johnson MJ, David JA, van der Net J, Feldman B, Berger K, Carcao M, de Kleijn P, Silva M, Hilliard P, Doria A, Srivastava A, Blanchette V; participants of the International Symposium on Outcome Measures in Hemophilic Arthropathy. Choosing outcome assessment tools in haemophilia care and research: a multidisciplinary perspective. Haemophilia. 2016 Sep.  C

Crivianu-Gaita V, Rivard GE, Carcao M, Teitel J, St-Louis J, Blanchette V, Pullenayegum E, Abad A, Feldman BM:  Pilot study of once-a-day prophylaxis for youth and young adults with severe haemophilia A.  Haemophilia.  2016 (22): e401 – e405.  SRA

Avila ML, Feldman BM, Williams S, Baena D, Montoya MI, Stinson J, Kiss A, Lara-Corrales I, Brandão LR: Collateral circulation in pediatric post-thrombotic syndrome. Thrombosis Research. 2016 Aug: 144: 210-2.  C

Avila ML, Brandao LR, Williams S, Ward LC, Montoya MI, Stinson J, Kiss A, Lara-Corrales I, Feldman BM: Pediatric post-thrombotic syndrome in children: toward the development of a new diagnostic and evaluative measurement tool. Thrombosis Research. 2016 Aug: 144: 184-91.  C

Enders FB, Bader-Meunier B, Baildam E, Constantin T, Dolezalova P, Feldman BM, Lahdenne P, Magnusson B, Nistala K, Ozen S, Pilkington C, Ravelli A, Russo R, Uziel Y, van Brussel M, van der Net J, Vastert S, Wedderburn LR, Wulffraat N, McCann LJ, van Royen-Kerkhof A: Consensus-based recommendations for the management of juvenile dermatomyositis. Annals of Rheumatic Diseases. 2016 Aug.  C

Villaça PR, Blanchette VS, Carneiro JD, Ozelo MC, Antunes S, Feldman BM, Abad A, Usuba K, Young NL:  Validity of the Portuguese CHO-KLAT in Brazil.  Haemophilia. 2016 Jul 25.  C.

Brosseau L, Toupin-April K, Wells GA, Smith CAM, Pugh AG, Stinson JN, Duffy CM, Gifford W, Moher D, Sherrington C, Cavallo S, De Angelis G, Loew L, Rahman P, Marcotte R, Taki J, Bisaillon J, King J, Coda A, Hendry GJ, Gauvreau J, Hayles M, Hayles K, Feldman B, et al:  Ottawa panel evidence-based clinical practice guidelines for foot care in the management of juvenile idiopathic arthritis.  Archives of Physical Medicine and Rehabilitation.  2016 Jul: 97 (7): 1163–1181.e14.  

Guzman J, Oen K, Huber AM, Duffy KW, Boire G, Shiff N, Berard RA, Feldman BM, et al:  The risk and nature of flares in juvenile idiopathic arthritis: results from the ReACCh-Out cohort. Annals of the Rheumatic Diseases.  2016 Jun: 75(6):1092-8.   C

Pullenayegum EM, Platt RW, Barwick M, Feldman BM, Offringa M, Thabane L.: Knowledge translation in biostatistics: a survey of current practices, preferences, and barriers to the dissemination and uptake of new statistical methods. Statistics in Medicine. 2016 Mar: 35 (6): 805-18.  C

Berger KC, Feldman BM, Wasserman J, Schramm W, Blanchette V, Fisher K: Securing reimbursement for patient centered haemophilia care: major collaborative efforts are needed.  Haematologica. 2016 Mar: 101(3): 266-8.  C

Diamond IR, Grant RC, Pencharz PB, de Silva N, Feldman BM, Fitzgerald P, Sigalet D, Dicken B, Turner J, Marchand V, Ling SC, Moore AM, Avitzur Y, Wales PW:  Preventing the progression of intestinal failure-associated liver disease in infants using a composite lipid emulsion: a pilot randomized controlled trial of SMOFlipid.  JPEN- Journal of Parenteral and Enteral Nutrition. 2016 Feb 2.  C

van der Stap DK, Rider LG,  Alexanderson H,  Huber AM,  Gualano B,  Gordon P,  van der Net J,  Mathiesen P,  Johnson LG,  Ernste FC,  Feldman BM, Houghton KM, Singh-Grewal D, Kutzbach AG, Alemo Munters L, Takken T: Proposal for a candidate core set of fitness and strength tests for patients with childhood or adult idiopathic inflammatory myopathies.  Journal of Rheumatology.  2016 Jan: 43(1): 169-76. C

A complete list of Dr. Feldman's publications is available on PubMed