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About Sickkids
About SickKids

Melvin Freedman, MD, CRCP(C), FRCP(C), FAAP

The Hospital for Sick Children
Senior Staff Physician and Haematologist-Oncologist

University of Toronto

Other Positions

The Hospital for Sick Children
Bone Marrow Transplant Team

The Hospital for Sick Children
Executive Committee, Severe Chronic Neutropenia International Registry

The Hospital for Sick Children
Organizing and Scientifc Committee, First International Symposim on Shwachman-Diamond Syndrome

The Hospital for Sick Children
American Society of Hematology
Abstract Reviewer for Annual Meeting

Phone: 416-813-6152
Fax: 416-813-5327
Email: melvin.freedman@sickkids.ca

Brief Biography

Dr. Melvin H. Freedman is Professor of Paediatrics at the University of Toronto and Director of the Hematopoiesis Research Laboratory at the Hospital for Sick Children. Dr. Freedman is a senior associate scientist in the Research Institute at the Hospital for Sick Children. He received his medical training at Dalhousie University and his Paediatric residency training at Montreal Children’s Hospital. In 1971, following haematology/oncology fellowships at the Children’s Hospital of Los Angeles and the Montreal General Hospital, Dr. Freedman joined the full-time faculty in the Division of Haematology/Oncology at the Hospital for Sick Children. Dr. Freedman is an internationally recognized expert in the field of hematopoiesis and the inherited bone marrow failure syndromes. He is a member of the executive and scientific advisory committees of the Severe Chronic Neutropenia International Registry, and a member of the medical advisory committee of the Diamond – Blackfan anemia registry. Dr. Freedman has published over 200 peer-reviewed papers and is author on several book chapters. He has lectured nationally and internationally on numerous research topics. During the period 1991 – 1997 Dr. Freedman was Chief of Haematology and Head of the Division of Haematology/Oncology at the Hospital for Sick Children.

Clinical Care Activities

Inherited and acquired bone marrow failure.

Areas of Specialty:

Normal and disordered hematopoiesis.

Academic Background

Paediatric Haematology/Oncology
Children's Hospital of Los Angeles, 1968-07-01 - 1970-07-01

Research Interests

Paediatric myelodysplastic syndromes.

Research Activities

The current focus of the laboratory is to understand the cellular and molecular basis of inherited bone marrow failure and its predisposition to hematologic malignancy


Freedman MH, Alter BP. Risk of myelodysplastic syndrome and acute myeloid leukemia in congenital neutropenias. Seminars in Hematology 2002; 39; 128-133.

Mandel K, Dror Y, Poon A, Freedman MH. A practical, comprehensive classification for pediatric myelodysplastic syndromes: The “CCC” system. Journal of Pediatric Hematology/Oncology 2002; 24: 596-605.

Lam V, Findley HW, Reed JC, Freedman MH, Goldenberg GJ. Comparison of DR5 and Fas expression levels relative to the chemosensitivity of acute lymphoblastic leukemia cell lines. Leukemia Research 2002; 26:503-513.

Sharathkumar A, Thornley I, Saunders EF, Calderwood S, Freedman MH, Doyle J. Allogenic bone marrow transplantation in children with chronic myelogenous leukemia. Journal of Pediatric Hematology/Oncology 2002; 24: 215-219.

Thornley I, Dror Y, Sung L, Wynn RF, Freedman MH. Abnormal telomere shortening in leucocytes of children with Shwachman-Diamond syndrome. British Journal of Haematology 2002; 117: 189-192.

Thornley I, Sutherland DR, Wynn RF, Nayar R, Sung L, Corpus G, Kiss T, Lipton J, Doyle JJ, Saunders EF, Kamel-Reid S, Freedman MH, Messner HA. Early hematopoietic reconstitution after clinical stem cell transplantation: evidence for stochastic stem cell behavior and limited acceleration in telomere loss. Blood 2002; 99: 2387-2396.

Freedman MH: Disorders of platelets in “Rudolph’s Pediatrics” CD Rudolph, AM Rudolph, MK Hostetter,G Lister, NJ Siegel (editors), McGraw-Hill Publishing , New York, NY 21st sedition , 2002; 1555-1560.

Freedman MH. Neutropenia in “Conn’s Current Therapy”, RE Rakal, ET Bope (editors), WB Saunders Company, Philadelphia, 54th edition, 2002; 380-384.

Thornley I, Freedman MH. Telomeres, x-inactivation ratios, and hematopoietic stem cell transplantations in humans. Stem Cells 2002; 20: 198-204.

Dror Y, Freedman MH. Shwachman-Diamond Syndrome. British Journal of Haematology 2002; 118: 701-713.

Al-Kasim FA, Thornley I, Rolland M, Lau W, Tsang R, Freedman MH, Saunders EF, Calderwood S, Doyle JJ. Single-centre experience with allogeneic bone marrow transplantation for acute lymphoblastic leukaemia in childhood: similar survival matched-related and matched-unrelated donor transplants. British Journal of Haematology 2002; 116: 483-490.