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About Sickkids
About SickKids

Yaron Finkelstein, MD, BSc (Med)

The Hospital for Sick Children
Staff Physician - Paediatric Emergency Medicine
Clinical Pharmacology and Toxicology

Research Institute
Senior Associate Scientist
Child Health Evaluative Sciences

University of Toronto
Associate Professor
Paediatrics, Pharmacology and Toxicology


Phone: 416-813-5317
Fax: 416-813-5043
Email: Yaron.Finkelstein@sickkids.ca

Brief Biography

Dr. Finkelstein is an Associate Professor of Pediatrics, Pharmacology and Toxicology, University of Toronto, and a staff physician, The Hospital for Sick Children, Toronto. He graduated from Sackler School of Medicine, Tel Aviv, Israel with thesis honors and completed pediatrics residency at Schneider Children’s Medical Center, where he then served as Associate Department Chief. Following Medical Toxicology training at the Chicago Toxikon, University of Illinois (2002) and a fellowship in Pediatric Clinical Pharmacology and Toxicology (2004-2007) and Emergency Medicine at the Hospital for Sick Children he joined on hospital staff. He is board-certified in Clinical Pharmacology (American Board of Clinical Pharmacology, 2007), and is an appointed Associate-Scientist in the Research Institute (Child Health Evaluative Sciences). Between 2008-2010 He was appointed an adjunct/visiting Associate Professor at Harvard Medical School, Boston.

Dr. Finkelstein’s main research focus is in pediatric therapeutics in acute-care settings. His long-term goal is optimization of drug safety, especially of highly toxic drugs and poisoning management and prevention in children. Using cutting-edge methodologies in pharmacogenetics, pharmacometrics, adverse drug-reaction analysis, translational research and epidemiological/toxico-surveillance tools he strives to enhance effective and safe drug delivery to children with an emphasis on emergency settings. Dr. Finkelstein has also made significant contributions to the understanding and prevention of pediatric poisonings, accidental and deliberate.

Dr. Finkelstein has published over 100 original and review articles in peer-reviewed journals, as well as book chapters in leading medical textbooks; he sits on scientific journals’ editorial boards and has an active role in various professional societies, such as the American College of Medical Toxicology. Dr. Finkelstein holds international scientific awards, and his research program is supported by local and international grants.

Academic Background

BSc

Medical Sciences, Tel Aviv University, Tel Aviv, Israel - 1990

MD

MD, Tel Aviv University, Tel Aviv, Israel - 1994

Post Doctoral Training

Medical Toxicology, Chicago Toxikon University, Children's Memorial Hospital, Chicago - 2002

Pediatric Clinical Pharmacology & Toxicology, University of Toronto - 2007

Clinical Pharmacology Certification - American Board of Clinical Pharmacology - 2007

Pediatric Emergency Medicine, University of Toronto - 2007

Research Interests

  • Optimization of paediatric drug safety in acute settings
  • Paediatric toxicology-poisoning management and prevention in children  

External Funding

St. Baldrick’s Foundation

McLauglin Centre for Genomic Medicine

British Columbia Children’s Hospital Foundation 

Rare Disease Foundation

Harvard Catalyst

International Rett Syndrome Association

Ontario Rett Syndrome Association

Children’s Hospital Boston Program for Patient Safety

Klitzberg Oncology Research Award

American Physicians Fellowship Grant

Visiting Scholar, The Medical Research Institute Council, Children’s Memorial Hospital (MRIC-CMH)

Publications

Selected List:

  • Y Finkelstein, J R Hutson, P Wax, J Brent. 
    Toxico-Surveillance of infant and Toddler poisoning in the United States: use of the Toxicology Investigators Consortium (ToxIC) Registry. 
    J Med Toxicol  2012 April 20 [Epub ahead of print]
  • JR Hutson, S. Weitzman, T. Schechter, RJ. Arceci, RB Kim, Y Finkelstein.
    Pharmacokinetic and pharmacogenetic determinants and considerations in chemotherapy selection and dosing in infants. 
    Exp Opin Drug Metab Toxicol. 2012 June 8(6): 709-22 
  • Y Finkelstein, T. Schechter, SB. Freedman.
    Surgical masks vs N95 respirators for preventing influenza.
    JAMA Mar 10:303(10):938, 2010 
  • T Schechter*/Y Finkelstein, A Lim, W Kahr, S Williams, AL Chan, G Deveber, LR Brandao.  
    Unfractionated heparin dosing in young infants: clinical outcomes in a cohort monitored by Anti-Xa levels.
    J Thromb Hemost. 2012 Mar;10(3):368-74
    * Co-first authors
  • T Schechter, A Kirton, S Laughlin, AM Pontigon, Y Finkelstein, D Macgregor, A Chan, G Deveber, LR Brandão. 
    Safety of anticoagulants in children with arterial ischemic stroke.
    Blood. 2012 Jan 26;119(4):949-56
  • S. Weitzman, Y Finkelstein, R. Arceci.  Neonatal Cancer.
    In: Rudolph CD, Rudolph AM, Hostetter MK, Lister GE, Siegel NJ.
    eds: Rudolph’s Textbook of Pediatrics, 22nd Ed.  New York, McGraw-Hill, Section 24 – Neoplastic Disorders, Chapter 447, pp1614-19, Feb 2011
  • Yaron Finkelstein .Chapter 6: Central Nervous System Drugs  (Faculty contributor). In: Browne AW, Dugani S, Hutson J, McSheffrey G, Stefater MA. 
    (Eds.): Pharmacology You See: A High Yield Pharmacology Review for Health Professionals.
    Toronto Notes and McGraw Hill Publ., Toronto. Pages 83-85, July 2011
  • D Lin, JA Seabrook, DM Matsui, SM King, MJ Rieder, Y Finkelstein.  
    Palatability, Adherence and Prescribing Patterns of Antiretroviral Drugs for Children with Human Immunodeficiency Virus Infection in Canada.  
    Pharmacoepidemiology and Drug Safety. 2011 Dec, 20(12): 1246-52
  • Y Finkelstein, G Soon, P Acuna, M George, E Pope, S Ito, N Shear, G Koren, MW Shannon, F Garcia-Bournissen.  
    Recurrence and Long-term Outcome of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Children.
    Pediatrics.  2011,128:4; pp 723-28
  • L Nurmohamed, ME Moretti, T Schechter, A Einarson, D Johnson, SV Lavigne, A Erebara, G Koren, Y Finkelstein
    Outcome following high-dose methotrexate in pregnancies misdiagnosed as ectopic.
    Am J Obstet Gynecol. 2011 Dec; 205 (6): 533 e1-3
  • Y Finkelstein, SE. Aks, JR. Hutson, DN. Juurlink, P. Nguyen, G. Dubnov-Raz, U. Pollak, G. Koren, Y. Bentur.  
    Colchicine poisoning: the dark side of an ancient drug.
    Clin Toxicol 2010; 48(5):407-14 (invited Review by Editor)
  • SM. Pollock-BarZiv, Y Finkelstein, C. Manlhiot, AI. Dipchand, D. Hebert, VL. Ng, M. Solomon, BW. McCrindle, D. Grant.
    Variability in Tacrolimus Blood Levels Increases the Risk of Late Rejection and Graft Loss after Solid Organ Transplantation in Older Children.
    Pediatric Transplantation Dec;14(8):968-75, 2010
  • S. Freedman, E. Powell, AA. Nava-Ocampo, Y Finkelstein.
    Ondansetron in Pediatric Gastroenteritis:  A Prospective Cohort, Dose-Response Study.
    Pediatric Drugs Dec 12(6): 405-10, 2010
  • L. Nurmohamed, F Garcia-Bournissen, R Buono, MW Shannon, Y Finkelstein.         
    Predisposition to Epilepsy-Does the ABCB1 Gene Play a Role?
    Epilepsia Sep 51(9):1882-85(4), 2010
  • D. Chirnomas, AL. Smith, J. Braunstein, Y Finkelstein, L. Pereira, AK. Bergmann, FD. Grant, C. Paley, M. Shannon, EJ. Neufeld.    
    Deferasirox Pharmacokinetics in Patients with Adequate versus Inadequate Response.
    Blood 114(19):4009-13, 2009
  • Y Finkelstein, FG. Bournissen, JR. Hutson, M. Shannon.
    Polymorphism of the ADRB2 Gene and Response to Inhaled Beta-Agonists in Children with Asthma: A Meta-Analysis.
    J Asthma 46(9):900-5, 2009
  • M. Glatstein, Y Finkelstein, D. Scolnik.
    Accidental Methadone Ingestion in an Infant: Case Report and Review of the Literature.
    Pediatr Emerg Care 25:109-11, 2009
  • Y. Finkelstein, AA. Nava-Ocampo, T. Schechter, R. Grant, E. St Pierre, R. Goldman, S. Walker, G. Koren.
    Discrepancies in Pharmacokinetic Analysis Results Obtained by Using Two Standard Population Pharmacokinetics Software Programs.
    Fundamental and Clinical Pharmacology 23:53-7, 2009
  • F. Garcia Bournissen, ME. Moretti, DN. Juurlink, G. Koren, M. Walker, Y. Finkelstein.
    Polymorphism of the ABCB1/ MDR1 C3435T Drug Transporter and Resistance to Anticonvulsant Drugs: A Meta-Analysis.
    Epilepsia 50:898-903, 2009
  • M Barton/Y Finkelstein**, T. Ho, EL. Ford-Jones, JL. Russel, G. Taylor, S. Ito, A. Opavsky, L. Benson, R. Gold.
    Eosinophilic Myocarditis Following Group C Meningococcal Conjugate and Hepatitis B Immunizations.  
    Ped Infect Dis J 27:831-835, 2008
    ** Co-first authors and the responsible author.
  • G. Dubnov, Juurlink DN, R Fogelman, P Merlob, Ito S, G Koren, Y. Finkelstein.
    Antenetal use of Selective Serotonin Reuptake Inhibitors and Qt Interval Prolongation in Newborns.
    Pediatrics 122:e710-715, 2008
  • Y Finkelstein. Chapter 9: Poisoning in Pregnancy.
    In: G Koren (Ed.): Medication Safety in Pregnancy and Breastfeeding.  
    McGraw Hill Publ., New York.
    Pages 121-128, 2007
  • Y Finkelstein, M. Wahl, D. Bentur, T. Schechter, BZ. Garty, G. Koren, S. Aks. Universal versus Selective Iron Supplementation for Infants and the Risk of Unintentional Poisoning in Young Children: A Comparative Study of Two Populations.
    Ann Pharmacother 41:414-419, 2007
  • M. Rezvani, Y Finkelstein, C. Railton, G. Koren.
    Generalized Seizures Following Topical Lidocaine Administration During Circumcision: Establishing Causation.  
    Pediatr Drugs 9:125-127, 2007
  • M. Avner, Y Finkelstein, D. Hackam, G. Koren.
    Establishing Causality in Pediatric Adverse Drug Reactions: Use of the Naranjo Probability Scale.  
    Pediatr Drugs 9:267-270, 2007
  • Y Finkelstein, T. Schechter, F. Garcia, L. Nurmohamed, D. Juurlink, V.  Blanchette, G. Koren.
    Is Morphine Exposure Associated with Acute Chest Syndrome in Children with Vaso-Occlusive Crisis of Sickle Cell Disease?  A 6-year Case-Crossover Study.
    Clin Ther 29:2738-2743, 2007
  • T. Schechter, Y Finkelstein, J. Doyle, Z. Verjee, M. Morretti, G. Koren, L. Dupuis.
    Pharmacokinetic Disposition and Clinical Outcomes in Infants and Children Receiving Intravenous Busulfan for Allogeneic Hematopoietic Stem Cell Transplantation.  
    Biol Blood Marrow Transplant 13:307-314, 2007
  • Y Finkelstein. Colchicine.
    In: TB Erickson, WR Ahrens, SE Aks, C Baum, L. Ling (Eds.):
    Pediatric Toxicology: Diagnosis and Management of the Poisoned Child.  
    McGraw Hill Publ., Chicago, p.253-257, 2005
  • Y Finkelstein, L. Nurmohamed, M. Avner, LN. Benson, G. Koren.
    Clopidogrel Use in Children.
    J Pediatr 147:657-661, 2005
  • Y Finkelstein, D. Chitayat, T. Schechter, S. Keating, A. Toi, G. Koren.  
    Warfarin Embryopathy Following Low Dose Maternal Exposure.
    J Obstet Gynaecol Can 27:702-706, 2005  
  • Y. Adler, Y. Finkelstein, J. Guindo, A. Rodriguez de la Serna, Y. Shoenfeld, A. Bayes-Genis, A. Sagie, A. Bayes de Luna, D.H. Spodick.
    Colchicine Treatment for Recurrent Pericarditis.  A Decade of Experience.  
    Circulation 97:2183-2185, 1998