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About Sickkids
About SickKids

Yaron Finkelstein, MD, FACMT

The Hospital for Sick Children
Staff Physician - Paediatric Emergency Medicine
Clinical Pharmacology and Toxicology

Research Institute
Senior Associate Scientist
Child Health Evaluative Sciences

University of Toronto
Professor
Paediatrics, Pharmacology and Toxicology

Other Positions

Institute of Clinical Evaluative Sciences (ICES)
Adjunct Scientist


Phone: 416-813-5317
Fax: 416-813-5043
Email: Yaron.Finkelstein@sickkids.ca

Brief Biography

Dr. Finkelstein is a Professor of Pediatrics, Pharmacology and Toxicology, University of Toronto, and a staff physician, The Hospital for Sick Children, Toronto. He graduated from Sackler School of Medicine, Tel Aviv, Israel with thesis honors and completed pediatrics residency at Schneider Children’s Medical Center, where he then served as Associate Department Chief. Following Medical Toxicology training at the Chicago Toxikon, University of Illinois (2002) and a fellowship in Pediatric Clinical Pharmacology and Toxicology (2004-2007) and Emergency Medicine at the Hospital for Sick Children he joined on hospital staff. He is board-certified in Clinical Pharmacology (American Board of Clinical Pharmacology, 2007), and is an appointed Senior Associate Scientist in the Research Institute (Child Health Evaluative Sciences). Between 2008-2010, he was appointed an adjunct/visiting Associate Professor at Harvard Medical School, Boston.

Dr. Finkelstein’s main research focus is in pediatric therapeutics in acute-care settings. His long-term goal is optimization of drug safety, especially of highly toxic drugs and poisoning management and prevention in children. Using cutting-edge methodologies in pharmacogenetics, pharmacometrics, adverse drug-reaction analysis, translational research and epidemiological/toxico-surveillance tools he strives to enhance effective and safe drug delivery to children with an emphasis on emergency settings. Dr. Finkelstein has also made significant contributions to the understanding and prevention of pediatric poisonings, accidental and deliberate.

Dr. Finkelstein has published over 100 original and review articles in peer-reviewed journals, as well as book chapters in leading medical textbooks; he sits on scientific journals’ editorial boards and has an active role in various professional societies, such as the American College of Medical Toxicology. Dr. Finkelstein holds international scientific awards, and his research program is supported by local and international grants.

Academic Background

BSc

Medical Sciences, Tel Aviv University, Tel Aviv, Israel - 1990

MD

MD, Tel Aviv University, Tel Aviv, Israel - 1994

Post Doctoral Training

Medical Toxicology, Chicago Toxikon University, Children's Memorial Hospital, Chicago - 2002

Pediatric Clinical Pharmacology & Toxicology, University of Toronto - 2007

Clinical Pharmacology Certification - American Board of Clinical Pharmacology - 2007

Pediatric Emergency Medicine, University of Toronto - 2007

Research Interests

  • Optimization of paediatric drug safety in acute settings
  • Paediatric toxicology-poisoning management and prevention in children  

External Funding

U.S. National Institute of Health

U.S. Centers for Disease Control and Prevention (CDC)

Canadian Institute of Health Research (CIHR)

Physicians Services Incorporated (PSI) Foundation

Cundill Foundation

SickKids Foundation

Ontario Child Health Support Unit (OCHSU)

Medical Psychiatry Alliance

St. Baldrick’s Foundation

McLauglin Centre for Genomic Medicine

British Columbia Children’s Hospital Foundation 

Rare Disease Foundation

Harvard Catalyst

International Rett Syndrome Association

Ontario Rett Syndrome Association

Children’s Hospital Boston Program for Patient Safety

Klitzberg Oncology Research Award

American Physicians Fellowship Grant

Visiting Scholar, The Medical Research Institute Council, Children’s Memorial Hospital (MRIC-CMH)

Achievements

2015    American Academy of Pediatrics - Best Research Award

2015    Fellowship, American College of Medical Toxicology (FACMT)

2013    American College of Medical Toxicology Service Award for Outstanding Contribution in Medical                  Toxicology Research

2012    Ronald D. Mann Award in Pharmacoepidemiology and Drug Safety

Publications

Selected List:

  • Y. Finkelstein,TM. Blonquist, V. Vijayanathan, K.E. Stevenson, D.S. Neuberg, LB. Silverman, LM. Vrooman, SE. Sallan, PD Cole. A thymidylate synthase polymorphism is associated with increased risk for bone toxicity among children treated for acute lymphoblastic leukemia. Pediatr Blood Cancer. 2017 Jul;64(7)
  • Dodiuk-Gad R, C. Olteanu, R. Hashimoto, H. Chew, A. Feinstein, R. Alhusayen, S.Whyte-Croasdaile, Y. Finkelstein, M. Burnett, S. Sade, R. Cartotto, M. Jeschke, N.H. Shear. Major psychological complications and decreased health related quality of life among survivors of Stevens-Johnson syndrome and toxic epidermal necrolysis. British Journal of Dermatology. 2016 Aug;175(2):422-4
  • Y.Finkelstein, Macdonald EM, Hollands S, Sivilotti ML, Hutson JR, Mamdani MM, Koren G, Juurlink DN; Canadian Drug Safety and Effectiveness Research Network (CDSERN). Repetition of Intentional Drug Overdose: A population-based study. Clin Toxicol (Phila). 2016 Aug;54(7):585-9]
  • PD Cole, Y. Finkelstein, K.E. Stevenson, T.M. Blonquist, V. Vijayanathan, L.B. Silverman, D.S. Neuberg, S.E. Sallan, P. Robaey, D.P. Waber. Polymorphisms in Genes Related to Oxidative Stress Are Associated with Inferior Cognitive Function after Therapy for Childhood ALL. Journal of Clinical Oncology 2015 Jul 1;33(19):2205-11
  • Y. Finkelstein, EM. Macdonald, S. Hollands, ML. Sivilotti, JR. Hutson, MM. Mamdani, G. Koren, DN. Juurlink; Canadian Drug Safety and Effectiveness Research Network (CDSERN). Long-term outcomes following self-poisoning in adolescents: A population-based cohort study. The LANCET Psychiatry 2015 June; 2(6), 532-539
  • Y. Finkelstein, EM. Macdonald, S. Hollands, ML. Sivilotti, JR. Hutson, MM. Mamdani, G. Koren, DN. Juurlink; Canadian Drug Safety and Effectiveness Research Network (CDSERN). Risk of Suicide Following Deliberate Self-poisoning. JAMA Psychiatry. 2015 June; 72(6):570-5
  • M. Imazio, A. Brucato, P. Ferrazzi, A. Pullara, Y. Adler, A. Barosi,  AL. Caforio, R. Cemin, F. Chirillo, C. Comoglio, D. Cugola, D. Cumetti, O. Dyrda, S. Ferrua, Y. Finkelstein, R. Flocco, A. Gandino, B. Hoit, F. Innocente, S. Maestroni, F. Musumeci, J. Oh, V. Polizzi, A. Ristic, C. Simon, DH. Spodick, V. Tarzia, S. Trimboli, A. Valenti, R. Belli, F. Gaita, for the COPPS-2 Investigators. Colchicine for prevention of post-pericardiotomy syndrome and post-operative atrial fibrillation: the COPPS-2 randomized clinical trial. JAMA. 2014 Sep 10, 312(10):1016-23
  • S Freedman, M Rumantir, E Uleryk, Y. Finkelstein. Ondansetron and the risk of cardiac arrhythmias: a systematic review and post-marketing analysis. Annals of Emergency Medicine   2014 Jul;64(1):19-25
  • Y. Finkelstein, EM. Macdonald, P. Li, JR. Hutson, DN. Juurlink. Recurrence and mortality following severe cutaneous adverse reactions. JAMA. 2014 Jun4;311(21):2231-2
  • OS. Khwaja, E. Ho, KV. Barnes, HM. O'Leary, L. Pereira, Y. Finkelstein, CA. Nelson, III, V. Vogel-Farley, DeGregorio,. IA. Holm, U. Khatwa, K. Kapur, ME. Alexander, DM. Finnegan, N. Cantwell, AC. Walco, L. Rappaport, M. Gregas, RN. Fichorova, MW. Shannon, M. Sur, WE. Kaufmann. Safety, pharmacokinetics, and preliminary assessment of efficacy of mecasermin (recombinant human IGF-1) for the treatment of Rett syndrome. PNAS-Proceedings of the National Academy of Sciences 2014 Mar 25; 111(12): 4596-601
  • A. Demirjian, Y. Finkelstein, A. Nava-Ocampo, A. Arnold, S. Jones, M. Monuteaux,. TJ. Sandora, A. Patterson, MB. Harper.  A Randomized Controlled Trial of a Vancomycin Loading Dose in Children. Pediatr Infec Dis J  2013 Nov;32(11):1217-23
  • Y Finkelstein, J R Hutson, P Wax, J Brent. Toxico-Surveillance of infant and Toddler poisoning in the United States: use of the Toxicology Investigators Consortium (ToxIC) Registry. J Med Toxicol  2012 April 20 [Epub ahead of print]
  • JR Hutson, S. Weitzman, T. Schechter, RJ. Arceci, RB Kim, Y Finkelstein. Pharmacokinetic and pharmacogenetic determinants and considerations in chemotherapy selection and dosing in infants. Exp Opin Drug Metab Toxicol. 2012 June 8(6): 709-22 
  • Y Finkelstein, T. Schechter, SB. Freedman. Surgical masks vs N95 respirators for preventing influenza. JAMA Mar 10:303(10):938, 2010 
  • T Schechter*/Y Finkelstein, A Lim, W Kahr, S Williams, AL Chan, G Deveber, LR Brandao. Unfractionated heparin dosing in young infants: clinical outcomes in a cohort monitored by Anti-Xa levels. J Thromb Hemost. 2012 Mar;10(3):368-74
    * Co-first authors
  • T Schechter, A Kirton, S Laughlin, AM Pontigon, Y Finkelstein, D Macgregor, A Chan, G Deveber, LR Brandão. Safety of anticoagulants in children with arterial ischemic stroke. Blood. 2012 Jan 26;119(4):949-56
  • S. Weitzman, Y Finkelstein, R. Arceci.  Neonatal Cancer. In: Rudolph CD, Rudolph AM, Hostetter MK, Lister GE, Siegel NJ. eds: Rudolph’s Textbook of Pediatrics, 22nd Ed.  New York, McGraw-Hill, Section 24 – Neoplastic Disorders, Chapter 447, pp1614-19, Feb 2011
  • Yaron Finkelstein .Chapter 6: Central Nervous System Drugs  (Faculty contributor). In: Browne AW, Dugani S, Hutson J, McSheffrey G, Stefater MA. (Eds.): Pharmacology You See: A High Yield Pharmacology Review for Health Professionals. Toronto Notes and McGraw Hill Publ., Toronto. Pages 83-85, July 2011
  • D Lin, JA Seabrook, DM Matsui, SM King, MJ Rieder, Y Finkelstein. Palatability, Adherence and Prescribing Patterns of Antiretroviral Drugs for Children with Human Immunodeficiency Virus Infection in Canada. Pharmacoepidemiology and Drug Safety. 2011 Dec, 20(12): 1246-52
  • Y Finkelstein, G Soon, P Acuna, M George, E Pope, S Ito, N Shear, G Koren, MW Shannon, F Garcia-Bournissen. Recurrence and Long-term Outcome of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Children. Pediatrics.  2011,128:4; pp 723-28
  • L Nurmohamed, ME Moretti, T Schechter, A Einarson, D Johnson, SV Lavigne, A Erebara, G Koren, Y Finkelstein. Outcome following high-dose methotrexate in pregnancies misdiagnosed as ectopic. Am J Obstet Gynecol. 2011 Dec; 205 (6): 533 e1-3
  • Y Finkelstein, SE. Aks, JR. Hutson, DN. Juurlink, P. Nguyen, G. Dubnov-Raz, U. Pollak, G. Koren, Y. Bentur. Colchicine poisoning: the dark side of an ancient drug. Clin Toxicol 2010; 48(5):407-14 (invited Review by Editor)
  • S. Freedman, E. Powell, AA. Nava-Ocampo, Y Finkelstein. Ondansetron in Pediatric Gastroenteritis:  A Prospective Cohort, Dose-Response Study. Pediatric Drugs Dec 12(6): 405-10, 2010
  • L. Nurmohamed, F Garcia-Bournissen, R Buono, MW Shannon, Y Finkelstein. Predisposition to Epilepsy-Does the ABCB1 Gene Play a Role? Epilepsia Sep 51(9):1882-85(4), 2010
  • D. Chirnomas, AL. Smith, J. Braunstein, Y Finkelstein, L. Pereira, AK. Bergmann, FD. Grant, C. Paley, M. Shannon, EJ. Neufeld. Deferasirox Pharmacokinetics in Patients with Adequate versus Inadequate Response. Blood 114(19):4009-13, 2009
  • Y Finkelstein, FG. Bournissen, JR. Hutson, M. Shannon. Polymorphism of the ADRB2 Gene and Response to Inhaled Beta-Agonists in Children with Asthma: A Meta-Analysis. J Asthma 46(9):900-5, 2009
  • Y. Finkelstein, AA. Nava-Ocampo, T. Schechter, R. Grant, E. St Pierre, R. Goldman, S. Walker, G. Koren. Discrepancies in Pharmacokinetic Analysis Results Obtained by Using Two Standard Population Pharmacokinetics Software Programs. Fundamental and Clinical Pharmacology 23:53-7, 2009
  • F. Garcia Bournissen, ME. Moretti, DN. Juurlink, G. Koren, M. Walker, Y. Finkelstein. Polymorphism of the ABCB1/ MDR1 C3435T Drug Transporter and Resistance to Anticonvulsant Drugs: A Meta-Analysis. Epilepsia 50:898-903, 2009
  • G. Dubnov, Juurlink DN, R Fogelman, P Merlob, Ito S, G Koren, Y. Finkelstein. Antenatal use of Selective Serotonin Reuptake Inhibitors and Qt Interval Prolongation in Newborns. Pediatrics 122:e710-715, 2008
  • Y Finkelstein, M. Wahl, D. Bentur, T. Schechter, BZ. Garty, G. Koren, S. Aks. Universal versus Selective Iron Supplementation for Infants and the Risk of Unintentional Poisoning in Young Children: A Comparative Study of Two Populations.
    Ann Pharmacother 41:414-419, 2007
  • Y Finkelstein, T. Schechter, F. Garcia, L. Nurmohamed, D. Juurlink, V.  Blanchette, G. Koren. Is Morphine Exposure Associated with Acute Chest Syndrome in Children with Vaso-Occlusive Crisis of Sickle Cell Disease?  A 6-year Case-Crossover Study. Clin Ther 29:2738-2743, 2007
  • Y Finkelstein. Colchicine. In: TB Erickson, WR Ahrens, SE Aks, C Baum, L. Ling (Eds.): Pediatric Toxicology: Diagnosis and Management of the Poisoned Child. McGraw Hill Publ., Chicago, p.253-257, 2005
  • Y Finkelstein, L. Nurmohamed, M. Avner, LN. Benson, G. Koren. Clopidogrel Use in Children. J Pediatr 147:657-661, 2005
  • Y Finkelstein, D. Chitayat, T. Schechter, S. Keating, A. Toi, G. Koren. Warfarin Embryopathy Following Low Dose Maternal Exposure. J Obstet Gynaecol Can 27:702-706, 2005  
  • Y. Adler, Y. Finkelstein, J. Guindo, A. Rodriguez de la Serna, Y. Shoenfeld, A. Bayes-Genis, A. Sagie, A. Bayes de Luna, D.H. Spodick. Colchicine Treatment for Recurrent Pericarditis. A Decade of Experience. Circulation 97:2183-2185, 1998